Leukeran is an immune system suppressing drug prescribed to help relieve or lessen the symptoms caused by chronic lymphatic leukemia and malignant lymphomas including lymphosarcoma, giant follicular lymphoma and Hodgkin’s disease.
Leukeran (chlorambucil) is indicated in the treatment of chronic lymphatic (lymphocytic) leukemia, malignant lymphomas including lymphosarcoma, giant follicular lymphoma, and Hodgkin’s disease. It is not curative in any of these disorders but may produce clinically useful palliation.
Possible Side Effects
Side effects with chlorambucil may come on slowly and tend to be most severe about 1-2 weeks after the drug is started. Common but not serious side effects include: Dogs: Loss of fur. Many dogs receiving chemotherapy will have minor hair coat changes (eg, shagginess, loss of luster). Breeds with continuously growing hair coats (eg, poodles, terriers, Afghan hounds, or old English sheepdogs) are more likely to experience significant hair loss.
Side effects that may be serious or indicate a serious problem: Low energy level or fever. Lack of appetite, vomiting, or diarrhea. Bleeding or bruising. Difficulty breathing. Agitation (ie, anxious, nervous, upset, unable to relax). Facial or eye twitching. Seizures (rare). Contact your veterinarian immediately if you see any of these signs
Drug & Food Interactions
Chlorambucil should not be used in patients whose disease has demonstrated a prior resistance to the agent. Patients who have demonstrated hypersensitivity to chlorambucil should not be given the drug. There may be cross-hypersensitivity (skin rash) between chlorambucil and other alkylating agents.
This medication should not be used in pets whose disease has demonstrated a prior resistance to the agent. Pets who have demonstrated hypersensitivity to this medication should not be given the drug. There may be cross-hypersensitivity between Leukeran and other agents.
This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.
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