Lysodren (Mitotane) Tablets, slide 1 of 1

Lysodren (Mitotane) Tablets

Prescription Item

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In stock
Strength: 500-mg
Count: 1 tablet
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Lysodren is an oral tablet prescription medication used to help those who suffer from pituitary-dependent Cushing's disease. Plus, it can be used to treat some of the symptoms associated with adrenal gland tumors.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.


Lysodren is indicated for the treatment of pets with inoperable, functional or nonfunctional, adrenal cortical carcinoma.

Possible Side Effects

Lethargy, weakness, lack of appetite, vomiting, diarrhea, incoordination, depression, and liver damage are possible. Your pet's appetite, water intake, and urination should decrease when Lysodren starts to work. Some pets may be truly allergic to this medication. Call your veterinarian if your pet is acting ill while taking Lysodren.

Drug & Food Interactions

Talk to your vet about any other drugs your pet is taking before starting this medication. 


Wear gloves when handling this medication. Adrenal crisis occurs in the setting of shock or severe trauma and response to shock is impaired, in pets taking this medication. If this occurs, administer hydrocortisone, monitor for escalating signs of shock, and discontinue until recovery.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

Please note product may arrive in a Chewy Pharmacy vial, manufacturer packaging is shown for reference.

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  1. Prescribing Information

See all items by Lysodren

  • Item Number
  • Common Brand Name(s)
  • Generic Name
  • For Use With
    Dogs & Cats
  • Administration Form
  • Product Form
  • Health Condition
    Cushing's Disease
  • Drug Type


Recommended Dosage

The recommended initial dose is 2 g to 6 g orally, in three or four divided doses per day. Your health care professional may ask you to increase doses incrementally or as tolerated.

Storage Instructions

Store at 77°F. Avoid exposure to extreme temperatures.


What is Lysodren?

This is an oral tablet that treats pituitary-dependent Cushing's disease (hyperadrenocorticism). It can also be used to treat some of the symptoms associated with adrenal gland tumors.

What are the benefits of Lysodren?

  • Easy to administer with a small amount of food or treat.
  • Helps to manage pituitary-dependent Cushings disease.
  • Can also help palliate some symptoms related to adrenal gland cancer.

How is this medication given?

Give exactly according to your veterinarians instructions. It is usually recommended to give this medication with a high fat treat or food to help increase absorption.

Your veterinarian will usually start your pet on a high dose at first and then gradually decrease the dose to the minimum dose to be effective. Your veterinarian will monitor your pet closely to make sure he/she is on the correct dose of medication. If you have questions about how to use Lysodren properly, always speak with your veterinarian.

How does this medication work?

With Cushing's disease and some types of tumors, excess steroid hormone is produced. Lysodren helps the adrenal gland to produce less steroid hormone so levels can return to normal.

What results can I expect?

Your pets symptoms associated with Cushings disease should improve with time but the response to Lysodren is individual. If Lysodren is helping, it is usually used chronically for the rest of your pets life.

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