Neo-Poly-Dex (Generic) Ophthalmic Suspension, slide 1 of 1

Neo-Poly-Dex (Generic) Ophthalmic Suspension, 5-mL

Prescription Item

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Neo-Poly-Dex is a multiple steroid eyedrop prescribed to help treat bacterial infections of the eyes and eyelids. Broad-spectrum action helps to treat different bacteria and it contains a corticosteroid that can help relieve related eye swelling and inflammation. Veterinarians use this medication to treat companion animals.

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This medication is indicated for the treatment of infection and inflammation in the eye.

Possible Side Effects

This medication is usually tolerated well. It can cause your pets eyes eye to sting for a short time when first applied. Dexamethasone can cause side effects like increased drinking/urination, and other symptoms if ingested. This medication can also cause infection more easily if used for longer periods.

Drug & Food Interactions

Always tell your vet about all other medications and supplements your pet is taking, as interactions may occur. 


Pets who are allergic to any of the ingredients should not be given this medication. If there is unhealed fungal or viral infection in the eye, this medication should not be used. Use is also contraindicated if an ulcer is present in the eye.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Chewy Pharmacy vial.

Also available in an eye cream.

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  1. Prescribing Information

See all items by Neo-Poly-Dex

  • Item Number
  • For Use With
    Dogs & Cats
  • Generic Name
    Neomycin, Polymyxin B Sulfates, Dexamethasone
  • Common Brand Name(s)
  • Administration Form
  • Product Form
  • Health Condition
    Eye Infections
  • Drug Type
    Antibiotic, Anti-inflammatory

Active Ingredients: Neomycin Sulfate (Equivalent to Neomycin) Polymyxin B Sulfate, Dexamethasone, Methylparaben and Propylparaben (Preservatives).

Inactive Ingredients: White Petrolatum, Lanolin, Mineral Oil.

Recommended Dosage

Apply this medication into the exactly as directed. Your veterinarian will teach you how to apply Neo/Poly/Dex correctly.

Storage Instructions

Store at room temperatures of 46° - 86°F.


What is Neo/Poly/Dex Ophthalmic Suspension?

These are prescription eye drops. This medication contains antibiotic and anti-inflammatory medications that are effective in the treatment of bacterial infections in the eyes/eyelids.

What are the benefits of Neo/Poly/Dex Ophthalmic Suspension?

Safe and effective formulation to treat the eyes and eyelids. Corticosteroids help to reduce associated inflammation. Safe to give to dogs and cats.

How is this medication given?

Neo/Poly/Dex Ophthalmic Suspension is topical medication that is placed directly in the eyes. Always follow your veterinarian's exact instructions regarding the use of this medication.

To use this medication, place one hand under and around your pet's chin and lift upward so that your pet's eyes are looking towards the ceiling and squeeze the prescribed quantity of eye drops into the corner of the affected eye(s) without touching the bottle directly to the eye surface.

Always wash your hands before and after treatment.

If your pet receives other eye medication(s), allow at least 5 minutes between applying each medication. Always call your veterinarian if you do not know how to use this medication correctly.

How does this medication work?

The antibiotics (neomycin and polymyxin B) stop the growth of bacteria in the eye and kill the bacteria eventually. Dexamethasone is a steroid that blocks the production of substances that trigger inflammation which helps to control related inflammation, redness, and itching.

What results can I expect?

Eye infection(s) and associated inflammation should start to improve after 48-72 hours of treatment if used as directed. Always call your veterinarian if the eye(s) look worse or are not improving.

Rating: 4.8 of 5 stars 7 Reviews 7 Reviews 4.9 out of 5 Stars

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Rating: 4.8 of 5 stars 4.9 / 5

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  • 5 out of 5 stars

    Pleased with Rx product

    By PatP on Dec 15, 2021

    I am very pleased with the product and most especially with the excellent customer service I always receive from Chewy! CHEWY IS THE BEST!!!

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  • 4 out of 5 stars

    This medication is okay so far

    By Trista on Aug 8, 2021

    I use this medication from my eye doctor I've only been using it for a few days so I can't give a complete review but from what I can see, it's doing its job but the only thing I can tell people is if you're going to take this medication take little tiny drops in your eyes do not put huge drops in your eyes only little tiny ones and start off slow even if your eye doctor tells you to take it three times a day take it once or twice a day start off slow make sure there's no burning or itching so far with me there's minor burning nothing to hurt me really the burning goes away in a few minutes because it's the medication is doing its job

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  • 5 out of 5 stars

    So easy with Chewy

    By John on Dec 1, 2021

    I received the prescription within a day. My pug is very happy and now seeing better thanks to Chewy!

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  • 5 out of 5 stars


    By coopie on Nov 25, 2021


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  • 5 out of 5 stars

    great service

    By BOGART on Oct 17, 2021

    i was very happy with my dogs meds purchase . fast shipping i .would recommend to buy your pets meds from chewy .. no problems

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  • 5 out of 5 stars

    saved money

    By rosie on Dec 2, 2021

    better price than the same item at the veterinarian

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  • 5 out of 5 stars

    Great product

    By pandajen on Dec 4, 2018

    My 12 year old Shar Pei mix was having a lot of eye irritation. The vet prescribed this and her eyes look so much better now. I know she is feeling better too! We used 2 drops per eye 2 times a day for the 1st month and now use 2 drops per eye one time a day ongoing.

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