NUTRAMAX Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Large Dogs, 30 count blister pack, bundle of 2 -

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Large Dogs

By Nutramax
Rated 4.5091 out of 5 stars
Breed Size

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$151.98Chewy Price
$144.38Autoship Price
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About This Item


  • Denamin contains s-adenosylmethionine (SAMe) to help increase gluthione levels to support your dog’s liver detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Questions & Answers

22 Customer Questions

What is the shape and size of the pill? Can it be crushed or broken into small pieces?

How long does it take for Denamarin to start working once started?
Answer by ChewyOct 14, 2017
This products takes 15 to 30 days for results.

Can I put the tablet in a pill pocket, even though it says to give on an empty stomach? What if my dog tries to chew the tablet since it says tablet should not be split or crushed?
Answer by ChewyAug 27, 2020
While these tablets may be chewed, they do not have to be in order to be effective. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than one tablespoon.

What are side effects?
Answer by ChewyFeb 28, 2022
The active ingredients in Denamarin® have been shown to be well-tolerated by both dogs and cats with a wide margin of safety. There are no known interactions of Denamarin® with drugs or other supplements.

ReviewsWrite a Review

Rated 4.5091 out of 5 stars
438 Reviews
Would recommend to a friend

438 Customer Reviews

Filter by reviews that mention

Rated 4 out of 5 stars
By Djjj on Feb 24, 2023

Works great

Last visit to my vet he said her liver counts were over 7000 which is beyond bad and pointing to Cushing's. I wanted to try a supplement before spending a few hundred dollars on tests. She didn't feel good at all the first week but slowly she has perked up and is back to her spicy self. You have to wait an hour after giving the pill and it takes a little coaxing to get her to eat so I think it upsets her stomach a bit but once she gets started she eats fine. I haven't taken her back to the vet as the test is expensive but I am grateful she is feeling better thanks to the Denamarin

Rated 5 out of 5 stars
By brendainaz on Mar 16, 2023

Different or the same???

I have always purchased the Denamarin in the punch out pill pack, but it's not available on Chewy, so I bought the bottle. The color of the tablets is different, but all the ingredients and the size seem to be alike. I have to admit that I'm confused. These bottled tablets are much less expensive, too.

Rated 5 out of 5 stars
By Jeanette on Feb 19, 2023

Great value

I used to get this from my vet pharmacy until for the 2nd time, they became backordered on this product for large dogs. Instead of getting 2 medium dog boxes which was much more expensive, I decided to check Chewy. Not only was the product not backordered, but it was $10 cheaper per box. I read the labels compared to the box I had at home. It's the exact same product. Love Chewy!

Rated 1 out of 5 stars
By Casey34 on Feb 2, 2023

Progressive Diarrhea

I wanted this supplement to help with my dog's Liver, but after taking the Denamarin for 2 1/2 weeks, Casey developed diarrhea (when she has ALWAYS had normal stools)...and it became progressively worse the longer she was on the Denamarin. I was giving her the dosage that was correct for her weight, but I couldn't subject her to the constant, worsening diarrhea. I'll be looking for alternative methods (probably natural, and diet based) to help with her Liver issues.

Rated 5 out of 5 stars
By Kait on Jan 20, 2023

it worked for my boxador

Last year my boxador presented with a distended abdomen, lethargy, and elevated liver enzymes. We have been giving Denamarin to her since then. Not long after she started it she began acting like her old self again. As of November, her enzymes are all back to normal except one that is barely above the parameters, but the vet isn’t worried about it because whichever enzyme it is is commonly elevated in geriatric dogs. She is 13.5 years old on Denamarin and Dasuquin, both made by the same company. These products have drastically improved her life and I would recommend them to anyone.

Rated 5 out of 5 stars
By DogMom on Feb 20, 2023

Denamarin Liver Supplement

The vet prescribed a liver supplement to counteract the effects of the arthritis medicine my dog has to take. Denamarin has been great and keeps his liver function levels steady. I use cheese, peanut better or pill pockets to administer and he's had no bad reaction to the supplement.

Rated 5 out of 5 stars
By Pitmom on Dec 18, 2022

Seems to be helping

I took my 13 yr old pitbull in for bloodwork as she had been drinking a ton of water and was always hungry. Her liver count couldn’t even be read by the machine. She’s been on this for almost three weeks and I’ve noticed she’s acting a lot like her old self even almost playing. She’s having less trouble on non carpeted floors also. This is her in the middle. We go back to have her bloodwork done again next month so I’m hopeful the machine will at least be able to read her numbers and she continues to improve.

Rated 5 out of 5 stars
By Marie123 on Dec 26, 2022

great product

Definitely a great product , our 11 year old pitmix is on it due to having some heavy duty seizure medications. A lot of the reviews comment on the medication having to be on an empty stomach … i simply give her meds before feeding time and I open her mouth and drop the pill in at the far back of her mouth … it’s not really difficult… The only problem I have is this significant price increase which is so shameful on the company’s part. Then people wonder why older dogs end up In shelters. Make pet care affordable for all.

Rated 3 out of 5 stars
By Sammy on Jan 28, 2023


You know, it honestly disgusts me that companies make you pay so much money for medication that is so important. My dog has liver issues. He will eventually die if he stops taking these to help control his ALT levels. His liver will fail. So every two weeks, I have to pay a ridiculous price for these pills.

Rated 5 out of 5 stars
By Eyes on Dec 27, 2022

Great Product

My dog was on these briefly until my dog's internist changed him to a different version which could only be purchased by the practice. During the time he took these, however, his energy seemed much better and he seemed like he felt better.