NUTRAMAX Denamarin with S-Adenosylmethionine & Silybin Tablet Liver Supplement for Large Dogs, 30 count -

Nutramax Denamarin with S-Adenosylmethionine & Silybin Tablets Liver Supplement for Large Dogs

By Nutramax
Rated 4.5056 out of 5 stars
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About This Item


  • Denamarin contains s-adenosylmethionine (SAMe) to help increase gluthione levels to support your dog’s liver detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Questions & Answers

21 Customer Questions

How long does it take for Denamarin to start working once started?
Answer by ChewyOct 14, 2017
This products takes 15 to 30 days for results.

Can I put the tablet in a pill pocket, even though it says to give on an empty stomach? What if my dog tries to chew the tablet since it says tablet should not be split or crushed?
Answer by ChewyAug 27, 2020
While these tablets may be chewed, they do not have to be in order to be effective. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than one tablespoon.

What are side effects?
Answer by ChewyFeb 28, 2022
The active ingredients in Denamarin® have been shown to be well-tolerated by both dogs and cats with a wide margin of safety. There are no known interactions of Denamarin® with drugs or other supplements.

You suggested splitting the pills if my dog requires 2, am and pm?
Answer by ChewyOct 06, 2018
It is recommended to take the suggested dose once a day.

ReviewsWrite a Review

Rated 4.5056 out of 5 stars
447 Ratings
Would recommend to a friend

447 Customer Reviews

Rated 5 out of 5 stars
By Susan on May 27, 2023

This stuff is mandatory for my pups' health

I have used Denamarin as a detoxifier for years. I was first introduced when my (now deceased) dog had elevated liver enzyme levels. It got her levels back down to a healthy range and I kept her on it for life. Now, I use Denamarin for my two younger dogs as a routine detoxifier to reduce the general chemical load (heartworm and flea meds, pesticides, etc.) I cannot avoid them being exposed to. I highly recommend!

Rated 2 out of 5 stars
By HeyAshMag on May 22, 2023

Not Helping

I started this supplement three months ago for my Labrador Retriever, who is 14.5 years old. Three months ago, his levels were 50% less than they were today when I had his labs re-tested. I will be discontinuing this supplement as I don't feel it's doing anything, and that it could actually be working the opposite way it's meant to for my sweet boy. Not blaming the med, but rather my dog's body and how things function for him.

Rated 3 out of 5 stars
By Di on May 25, 2023


Not sure at this point how it is doing. She seemed to start acting sluggish. Took her off for a few days to see if any changes per vet. Seems bit more active.

Rated 5 out of 5 stars
By luvdogs on May 11, 2023

Great Product!

Denamarin works! My dogs liver enzymes were really high due to liver tumors. After using this product for about a month, her liver enzymes went down dramatically. Highly recommended!

Rated 4 out of 5 stars
By Djjj on Feb 24, 2023

Works great

Last visit to my vet he said her liver counts were over 7000 which is beyond bad and pointing to Cushing's. I wanted to try a supplement before spending a few hundred dollars on tests. She didn't feel good at all the first week but slowly she has perked up and is back to her spicy self. You have to wait an hour after giving the pill and it takes a little coaxing to get her to eat so I think it upsets her stomach a bit but once she gets started she eats fine. I haven't taken her back to the vet as the test is expensive but I am grateful she is feeling better thanks to the Denamarin

Rated 5 out of 5 stars
By SandBoxCity on Apr 18, 2023

Prescribed by Vet - For my best Friend

This prescription Denamarin is prescribed by the Vet for my old girl. There arent any side effects and she's doing great. I am not a doc or vet. I feel the supplement must be doing her good as she's feeling better.

Rated 5 out of 5 stars
By Jeanette on Feb 19, 2023

Great value

I used to get this from my vet pharmacy until for the 2nd time, they became backordered on this product for large dogs. Instead of getting 2 medium dog boxes which was much more expensive, I decided to check Chewy. Not only was the product not backordered, but it was $10 cheaper per box. I read the labels compared to the box I had at home. It's the exact same product. Love Chewy!

Rated 5 out of 5 stars
By moxie on Apr 9, 2023

It really works

My 12 year old mixed breed is undergoing chemotherapy for Mast Cell disease. The medication was causing elevated liver numbers and Denamarin has brought those numbers back to normal.

Rated 1 out of 5 stars
By Casey34 on Feb 2, 2023

Progressive Diarrhea

I wanted this supplement to help with my dog's Liver, but after taking the Denamarin for 2 1/2 weeks, Casey developed diarrhea (when she has ALWAYS had normal stools)...and it became progressively worse the longer she was on the Denamarin. I was giving her the dosage that was correct for her weight, but I couldn't subject her to the constant, worsening diarrhea. I'll be looking for alternative methods (probably natural, and diet based) to help with her Liver issues.

Rated 5 out of 5 stars
By brendainariz on Mar 16, 2023

Different or the same???

I have always purchased the Denamarin in the punch out pill pack, but it's not available on Chewy, so I bought the bottle. The color of the tablets is different, but all the ingredients and the size seem to be alike. I have to admit that I'm confused. These bottled tablets are much less expensive, too.