NUTRAMAX Denamarin Tablets with S-Adenosylmethionine (SAMe) & Silybin Liver Health Supplement for Large Dog, 30 count -

Nutramax Denamarin Tablets with S-Adenosylmethionine (SAMe) & Silybin Liver Health Supplement for Large Dogs

By Nutramax
Rated 4.5187 out of 5 stars
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$75.99Chewy Price
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About This Item


  • Denamin contains s-adenosylmethionine (SAMe) to help increase gluthione levels to support your dog’s liver detoxification capabilities.
  • Silybin found in Denamarin has shown better absorption in dogs than the milk thistle extract found in many other products.
  • Supporting your dog’s liver health promotes the liver’s ability to remove toxins, store energy, aid digestion and support the immune system.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Questions & Answers

23 Customer Questions

How long does it take for Denamarin to start working once started?
Answer by ChewyOct 14, 2017
This products takes 15 to 30 days for results.

Can I put the tablet in a pill pocket, even though it says to give on an empty stomach? What if my dog tries to chew the tablet since it says tablet should not be split or crushed?
Answer by ChewyAug 27, 2020
While these tablets may be chewed, they do not have to be in order to be effective. This medication should be administered on an empty stomach at least 1 hour before eating. If you must mask with food it is recommended to use no more than one tablespoon.

What are side effects?
Answer by ChewyFeb 28, 2022
The active ingredients in Denamarin® have been shown to be well-tolerated by both dogs and cats with a wide margin of safety. There are no known interactions of Denamarin® with drugs or other supplements.

You suggested splitting the pills if my dog requires 2, am and pm?
Answer by ChewyOct 06, 2018
It is recommended to take the suggested dose once a day.

ReviewsWrite a Review

Rated 4.5187 out of 5 stars
428 Reviews
Would recommend to a friend

428 Customer Reviews

Filter by reviews that mention

Rated 1 out of 5 stars
By Casey34 on Feb 2, 2023

Progressive Diarrhea

I wanted this supplement to help with my dog's Liver, but after taking the Denamarin for 2 1/2 weeks, Casey developed diarrhea (when she has ALWAYS had normal stools)...and it became progressively worse the longer she was on the Denamarin. I was giving her the dosage that was correct for her weight, but I couldn't subject her to the constant, worsening diarrhea. I'll be looking for alternative methods (probably natural, and diet based) to help with her Liver issues.

Rated 5 out of 5 stars
By Kait on Jan 20, 2023

it worked for my boxador

Last year my boxador presented with a distended abdomen, lethargy, and elevated liver enzymes. We have been giving Denamarin to her since then. Not long after she started it she began acting like her old self again. As of November, her enzymes are all back to normal except one that is barely above the parameters, but the vet isn’t worried about it because whichever enzyme it is is commonly elevated in geriatric dogs. She is 13.5 years old on Denamarin and Dasuquin, both made by the same company. These products have drastically improved her life and I would recommend them to anyone.

Rated 3 out of 5 stars
By Sammy on Jan 28, 2023


You know, it honestly disgusts me that companies make you pay so much money for medication that is so important. My dog has liver issues. He will eventually die if he stops taking these to help control his ALT levels. His liver will fail. So every two weeks, I have to pay a ridiculous price for these pills.

Rated 5 out of 5 stars
By Pitmom on Dec 18, 2022

Seems to be helping

I took my 13 yr old pitbull in for bloodwork as she had been drinking a ton of water and was always hungry. Her liver count couldn’t even be read by the machine. She’s been on this for almost three weeks and I’ve noticed she’s acting a lot like her old self even almost playing. She’s having less trouble on non carpeted floors also. This is her in the middle. We go back to have her bloodwork done again next month so I’m hopeful the machine will at least be able to read her numbers and she continues to improve.

Rated 5 out of 5 stars
By Marie123 on Dec 26, 2022

great product

Definitely a great product , our 11 year old pitmix is on it due to having some heavy duty seizure medications. A lot of the reviews comment on the medication having to be on an empty stomach … i simply give her meds before feeding time and I open her mouth and drop the pill in at the far back of her mouth … it’s not really difficult… The only problem I have is this significant price increase which is so shameful on the company’s part. Then people wonder why older dogs end up In shelters. Make pet care affordable for all.

Rated 5 out of 5 stars
By Eyes on Dec 27, 2022

Great Product

My dog was on these briefly until my dog's internist changed him to a different version which could only be purchased by the practice. During the time he took these, however, his energy seemed much better and he seemed like he felt better.

Rated 5 out of 5 stars
By Sarah on Nov 19, 2022

Love this for my aging dog!

After a recent health scare, I was prescribed this for my 13 year old dog at the ER. We went for a follow up visit to my primary vet and his liver levels were going down thanks to this medication and the vet recommended keeping him on it. I will gladly do so if it means I can have my sweet dog around longer! I am very happy with this product!

Rated 1 out of 5 stars
By Joely on Nov 4, 2022

Don't Give This To Your Dog

The vet recommended Denamarin for our senior dog after having surgery with six tumors removed (two of which were cancerous). The lab report said all the cancer was removed. She was doing great. She healed wonderfully and continued to eat as normal. Two months later after being on Denamarin, we had to put her down. Don't ever give Denamarin to your dog.

Rated 5 out of 5 stars
By Vader1013 on Oct 10, 2022

Worked well for my dog!

After routine bloodwork for my senior dog’s (11 years old) liver values were found to be high, my vet recommended I put my my dog on Denamarin for 30 days and then recheck. this was to see if her liver could be supported by this and react positively, or if there was not a positive reaction, that we could investigate further into the possible cause. luckily, her values dropped enough that they put her back into the high end of normal. So, we waited for six months and tested it again. She had essentially maintained around the same numbers on the high end of normal. I wanted to see if we could get the numbers better, so I put her on this regularly for three months, and then we rechecked again. We were both very excited – and I was very relieved-to see that her numbers had dropped back down into “the best numbers she’s had since we’ve been testing” (according to the vet). I had been familiar with this nutraceutical because years ago one of my dogs that was going through chemotherapy was given this by his oncologist to support and liver functions during chemo it had worked for him, but I have not used it completely healthy dog. I would highly recommend anyone whose dog has received an elevated liver enzyme report to discuss this option with their doctor.

Rated 5 out of 5 stars
By Sarge on Jan 28, 2023

Excellent liver supplement

Our Lab needs to take a supplement for her liver. Denamarin was recommended by her vet. We add to her food daily.