Ora-Clens Denestra 100mg SAMe Dog & Cat Supplement, 60 count
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For fur-buddies with liver issues or joint problems, Ora-Clens Denestra 100mg SAMe Dog & Cat Supplement can provide relief. Denestra supplies 100mg of active SAMe to support liver function and help alleviate joint pain and inflammation. SAMe has also been used as an antidepressant and can help with low energy levels and for cognitive support, too. Great for older pets who often suffer from both liver and joint trouble and younger buddies with either ailment, the enteric-coated tablets can be administered directly or hidden in treats.
Key Benefits- A daily nutritional supplement for cats and dogs.
- Contains 100 mg of active SAMe (S-adenosylmethionine) in enteric-coated tablets.
- Helps support healthy liver and cognitive function.
- Provides joint support and can help alleviate inflammation.
- For pets with osteoarthritis or depressed liver function.
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Item Number175632
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LifestageAdult
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Breed SizeSmall Breeds, Medium Breeds, Large Breeds, All Breeds
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Food FormSupplement
S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate, Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).
Denestra should be administered on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage at any time at the recommendation or your veterinarian.
Why should I include vitamins & supplements in my pet’s diet?
Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.
How often should I give this supplement to my pet?
It is recommended to give the suggested dosage based off your pet’s weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.
Is this supplement safe to use with the medication my pet is currently taking?
If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.
My pet is allergic to certain ingredients, will this product be safe to use?
For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.
Does this product come in other product forms?
For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.
Customer Reviews

75% Recommend
75% of reviewersrecommend this product
You've Already Reviewed This Item
4 Reviews
4 Reviews
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Good for cat cognitive dysfunction
By MelD on Sep 4, 2020
My senior cat, who is at least 16 yrs old, recently started showing signs of cognitive dysfunction syndrome (dementia) and this was recommended. While there’s not a medical way to test if this is working, I do believe it helps. He has a few other health issues, one being chronic pancreatitis. If he pukes from the pancreatitis and the SAMe hasn’t fully dissolved yet (it seems to be slow release) he will throw it up. When that happens, he tends to have an uptick in his dementia. (When he’s having an episode, his ability to drink water is affected, but not his ability to eat food. It seems as though the part of his brain that tells his tongue to work is affected.) This very thing happened tonight My senior cat, who is at least 16 yrs old, recently started showing signs of cognitive dysfunction syndrome (dementia) and this was recommended. While there’s not a medical way to test if this is working, I do believe it helps. He has a few other health issues, one being chronic pancreatitis. If he pukes from the pancreatitis and the SAMe hasn’t fully dissolved yet (it seems to be slow release) he will throw it up. When that happens, he tends to have an uptick in his dementia. (When he’s having an episode, his ability to drink water is affected, but not his ability to eat food. It seems as though the part of his brain that tells his tongue to work is affected.) This very thing happened tonight and while we have had a week+ without a dementia incident, since he threw up and the pill came up, he’s had some issue with water. That’s a long winded story of why I think this product is 10/10. … more
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Works Well fo my Pups Liver
By RachelleW on Aug 7, 2020
I am very happy with this product. My pup has liver issues and the vet recommended this. My pup was to take it a hour before feeding or two hours after. We followed the directions and my pup no longer was burping and licking anymore. His stomach felt better and his liver is doing so much better. So happy that Ora-clena Sam-e is helping my pup.
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No info on shipment
By Kathy on May 13, 2020
Placed first time order. Message on site said they were delayed but would get out quickly which was fine. After 10 days without receiving order info, status or acknowledgment order placed, I sent email asking if knew when it would be shipped. Received email back to let me know they would respond within three days. The next day received email saying they hoped to have it delivered by 5/8. I still had no order number or tracking number. The order showed up on 5/6. I'm glad it arrived however the lack of info was bad service.
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Rip off dont buy
By Dixie on May 10, 2020
10 of the blisters were empty I expect a credit for the 10 that I was shorted.