Ora-Clens Denestra 400mg SAMe Dog Supplement, 60 count

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Ora-Clens Denestra 400mg SAMe Dog Supplement was made to help your buddy with liver or joint issues feel better. With 400 mg of active SAMe per tablet, Denestra helps encourage proper liver function while also supporting joint health. Great for larger* breeds and older dogs who often experience both joint and liver issues at the same time, this supplement addresses both problems and can help with depression and cognitive decline, too. The stabilized enteric-coated tablets can be given directly or hidden in treats for easier administration.

Key Benefits
  • A daily nutritional supplement for dogs with liver problems and/or joint trouble.
  • Each enteric-coated tablet contains 400 mg of active SAMe.
  • Helps aid liver function and boost liver metabolic activity.
  • Supports healthy joints and helps alleviate inflammation.
  • Ideal for senior dogs or breeds prone to joint problems and liver issues.

See all items by Ora-Clens

  • Item Number
  • Lifestage
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Food Form
Nutritional Info

S-Adenosyl-L-methionine disulfate p-toluensulfonate, Microcrystalline cellulose, Mannitol, Carboxymethylstarch sodium salt, Colloidal silica anhydrous, Glycerol behenate, Magnesium stearate, Methacrylic acid copolymer, Glycerol palmitostearate, Medium chain triglycerides, Titanium dioxide, Colloidal silica anhydrous, Talc, Triethyl citrate, Yellow iron oxide (III).

Feeding Instructions

Denestra should be administered on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration. Dosage at any time at the recommendation or your veterinarian.


Why should I include vitamins & supplements in my pet’s diet?

Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.

How often should I give this supplement to my pet?

It is recommended to give the suggested dosage based off your pet’s weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.

Is this supplement safe to use with the medication my pet is currently taking?

If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.

My pet is allergic to certain ingredients, will this product be safe to use?

For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.

Does this product come in other product forms?

For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.

Rating: 5.0 of 5 stars 3 Reviews 3 Reviews 5 out of 5 Stars

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  • 5 out of 5 stars

    Great product

    By Michy on Jan 30, 2021

    I was told by my vet that my dog’s liver enzymes were up & needed a supplement... so I bought this product & just by the dog taking it I can tell she’s better because she’s playing more, where before she was just lying around...

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  • 5 out of 5 stars

    Liver inflammation treatment

    By Great on Sep 28, 2020

    My 12-year-old shepherd mix had his annual physical, his blood drawn and there were some issues. Did an ultrasound and found a large mass on his liver. This was prescribed by my vet for the inflammation as we are going to treat holistically only. I found out the results on a Friday afternoon, searched the Internet for this SAMe, found it on Chewy at a great price, ordered it around 10 o’clock on Friday Night and it was at my door Saturday at noon. Chewy is fabulous! Great price too. It was so nice to have the stress of finding this medication so easily, and getting it so quickly. My dog is my best friend and Chewy took care of him once again, thank you!

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  • 5 out of 5 stars

    Liver disease

    By Marguerite on Jun 12, 2020

    My dog has the beginning of liver disease and needed this supplement

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