Pet MD SAMe Plus Dog Supplement, 60 count

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Help your pup stay wise and sharp with the Pet MD SAMe Plus Dog Supplement. It’s veterinarian formulated to help maintain proper liver health and brain function in dogs. The formula works by helping to balance the amount of SAMe in your dog’s body, a naturally-occurring molecule in charge of making important chemicals and hormones to support cell regeneration for liver and brain health. It also contains antioxidants to help neutralize free radicals, B vitamins to support healthy energy levels, and targeted essential amino acids that help make glutathione, a “master antioxidant” that detoxifies and protects liver cells. Because it helps maintain normal mental function, it’s ideal for older dogs to help slow down memory loss and mental decline, as well as for dogs with aging-related behavioral disorders. Plus, the tablets are enteric coated to ensure the powerful ingredients are absorbed in your dog’s tummy.

Key Benefits
  • Supports healthy production of brain chemicals to promote cognitive function and help slow memory loss in older dogs.
  • Contains SAMe, a natural molecule that’s essential to brain and liver health for dogs.
  • Helps support a healthy liver by helping cells detoxify and repair with antioxidants and glutathione-supporting amino acids.
  • Ideal for older dogs to help slow down cognitive dysfunction, memory loss, and aging-related behavioral disorders.
  • Made in small batches in the USA in an FDA, USDA and FSIS regulated manufacturing facility, and enteric coated for maximum absorption.

For animal use only. Keep out of reach of children and other animals. In case of accidental overdose, contact a veterinarian immediately. Safe use in pregnant animals or animals intended for breeding has not been proven. If animals’ condition worsens or does not improve, discontinue use and consult a veterinarian. Caution in use with antidepressants.

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  • Item Number
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds
  • Food Form
  • Lifestage
    Adult, Senior, Puppy
  • Made in
    United States
  • Product Form
    Chewable Tablet
Nutritional Info

Active Ingredients: S-Adenosyl-L-Methionine: 225 mg, Vitamin E (d-alpha Tocopherol) 50 IU, N-Acetyl Cysteine: 40 mg, L-Taurine 33 mg, Zinc Ascorbate 20 mg, Vitamin B6 (Pyridoxine HCl): 50 mg, B-Complex Proprietary Blend: 14 mg, Biotin, Vitamin B3 (Niacin), Vitamin B5 (Calcium-D-Pantothenate), Vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B12 (Cyanocobalamin), Vitamin B9 (Folic Acid).

Inactive Ingredients: Coating Agents, Croscarmellose Sodium, Dicalcium Phosphate, Magnesium Stearate, Stearic Acid.

Feeding Instructions

Absorption of SAMe Plus is decreased when it is given with a meal. For optimal absorption, administer tablets at least 1 hour before feeding your dog. For owners who find it difficult to administer SAMe Plus to your dogs, the tablets may be disguised in a small bite of moist food or treat. It is not necessary to withhold water from your dog when giving tablets. Tablets should not be broken as the enteric coating of our SAMe Plus tablets protects the active ingredients from destruction while in the stomach. Tablets hould not be split or crumbled.

  • 13 - 40 lbs: 1 tablet daily
  • 41 - 90 lbs: 2 tablets daily
  • Over 90 lbs: 3 tablets daily

Tablets are sensitive to moisture and heat. Store in temperature and humidity controlled environment.

Customer Reviews

5 Reviews 5 Reviews 4.2 out of 5 Stars

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  • 5 out of 5 stars

    Outstanding product...

    By on

    I am giving this to my almost 16 year old Westie who has been exhibiting cognitive problems and some physical limitations. I saw an almost immediate difference in both his cognitive state and in his physical ability to perform actions such as climbing steps. Giving him this Sam-E plus melatonin has also increased his ability to sleep through the night. I would definitely recommend.

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  • 5 out of 5 stars


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  • 5 out of 5 stars

    Works great

    By on

    I’m using half the recommended dose and can see a big improvement in my 15 year old dog. It’s amazing.

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  • 1 out of 5 stars

    Didn't realize

    By on

    For my purpose, it needed to be a snap tab rather than an enteric pill. It is too big for my dog and needs to be chewed. Not supposed to break into an enteric pill. So this bottle is of no use to me and I have ordered the snap tab version from another vendor

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  • 5 out of 5 stars

    Excellent product

    By on

    Our vet recommended we give 225 mg of samE and liked that this product also had b vitamins. Her liver enzyme levels have returned to normal.

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