Pet MD SAMe Plus Dog Supplement, 60 count

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Help your pup stay wise and sharp with the Pet MD SAMe Plus Dog Supplement. It’s veterinarian formulated to help maintain proper liver health and brain function in dogs. The formula works by helping to balance the amount of SAMe in your dog’s body, a naturally-occurring molecule in charge of making important chemicals and hormones to support cell regeneration for liver and brain health. It also contains antioxidants to help neutralize free radicals, B vitamins to support healthy energy levels, and targeted essential amino acids that help make glutathione, a “master antioxidant” that detoxifies and protects liver cells. Because it helps maintain normal mental function, it’s ideal for older dogs to help slow down memory loss and mental decline, as well as for dogs with aging-related behavioral disorders. Plus, the tablets are enteric coated to ensure the powerful ingredients are absorbed in your dog’s tummy.

Key Benefits
  • Supports healthy production of brain chemicals to promote cognitive function and help slow memory loss in older dogs.
  • Contains SAMe, a natural molecule that’s essential to brain and liver health for dogs.
  • Helps support a healthy liver by helping cells detoxify and repair with antioxidants and glutathione-supporting amino acids.
  • Ideal for older dogs to help slow down cognitive dysfunction, memory loss, and aging-related behavioral disorders.
  • Made in small batches in the USA in an FDA, USDA and FSIS regulated manufacturing facility, and enteric coated for maximum absorption.

For animal use only. Keep out of reach of children and other animals. In case of accidental overdose, contact a veterinarian immediately. Safe use in pregnant animals or animals intended for breeding has not been proven. If animals’ condition worsens or does not improve, discontinue use and consult a veterinarian. Caution in use with antidepressants.

See all items by Pet MD

  • Item Number
  • Lifestage
    Adult, Senior, Puppy
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds, All Breeds
  • Food Form
  • Product Form
    Chewable Tablet
Nutritional Info

Active Ingredients: S-Adenosyl-L-Methionine: 225 mg, Vitamin E (d-alpha Tocopherol) 50 IU, N-Acetyl Cysteine: 40 mg, L-Taurine 33 mg, Zinc Ascorbate 20 mg, Vitamin B6 (Pyridoxine HCl): 50 mg, B-Complex Proprietary Blend: 14 mg, Biotin, Vitamin B3 (Niacin), Vitamin B5 (Calcium-D-Pantothenate), Vitamin B1 (Thiamine), Vitamin B2 (Riboflavin), Vitamin B12 (Cyanocobalamin), Vitamin B9 (Folic Acid).

Inactive Ingredients: Coating Agents, Croscarmellose Sodium, Dicalcium Phosphate, Magnesium Stearate, Stearic Acid.

Feeding Instructions

Absorption of SAMe Plus is decreased when it is given with a meal. For optimal absorption, administer tablets at least 1 hour before feeding your dog. For owners who find it difficult to administer SAMe Plus to your dogs, the tablets may be disguised in a small bite of moist food or treat. It is not necessary to withhold water from your dog when giving tablets. Tablets should not be broken as the enteric coating of our SAMe Plus tablets protects the active ingredients from destruction while in the stomach. Tablets hould not be split or crumbled.

  • 13 - 40 lbs: 1 tablet daily
  • 41 - 90 lbs: 2 tablets daily
  • Over 90 lbs: 3 tablets daily

Tablets are sensitive to moisture and heat. Store in temperature and humidity controlled environment.


Why should I include vitamins & supplements in my pet’s diet?

Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.

How often should I give this supplement to my pet?

It is recommended to give the suggested dosage based off your pet’s weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.

Is this supplement safe to use with the medication my pet is currently taking?

If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.

My pet is allergic to certain ingredients, will this product be safe to use?

For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.

Does this product come in other product forms?

For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.

Rating: 4.0 of 5 stars 9 Reviews 9 Reviews 4 out of 5 Stars

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78% Recommend

78% of reviewersrecommend this product

Rating: 4.0 of 5 stars 4 / 5

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9 Reviews

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  • 1 out of 5 stars

    Didn't help

    By on

    This product didn't work for my dog. She is nearly 15 years old and it caused her to have loose stools. I would suggest that people be careful with older dogs and this product. It didn't help to keep her calm either or help her sleep.

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  • 5 out of 5 stars

    Works Great for our 14+ yo Lab X

    By on

    We rescued our little girl 14+ years ago. She is now about 40 lbs. She is overall healthy. Around October last year we noticed that she was getting a lot slower, not really in a play mode, kinda confused, lack of hearing. There were scary moments, when we tried to wake her up she didn't response. I searched online and found Pet MD SAMe +. Shortly after we gave her SAMe+ she acts more normal. She is now more energetic and happier. We walk her 2 - 3+ miles a day. Thank you Chewy for having this product available!

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  • 4 out of 5 stars

    Easy to Administer

    By on

    Doc suggested this to address slightly elevated liver enzymes in my 11 year old Brittany. I don't know if it's him or the pill, but I just drop it into his kibble and he eats it - no need to wrap it in peanut butter or such. Couldn't give a "5" rating because we won't know if it's doing what's expected 'til his next blood test.

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  • 5 out of 5 stars

    Great Products and Affordable

    By on

    I love using Chewy! Their prices are very reasonable.

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  • 5 out of 5 stars

    Outstanding product...

    By on

    I am giving this to my almost 16 year old Westie who has been exhibiting cognitive problems and some physical limitations. I saw an almost immediate difference in both his cognitive state and in his physical ability to perform actions such as climbing steps. Giving him this Sam-E plus melatonin has also increased his ability to sleep through the night. I would definitely recommend.

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  • 5 out of 5 stars


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  • 5 out of 5 stars

    Works great

    By on

    I’m using half the recommended dose and can see a big improvement in my 15 year old dog. It’s amazing.

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  • 1 out of 5 stars

    Didn't realize

    By on

    For my purpose, it needed to be a snap tab rather than an enteric pill. It is too big for my dog and needs to be chewed. Not supposed to break into an enteric pill. So this bottle is of no use to me and I have ordered the snap tab version from another vendor

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  • 5 out of 5 stars

    Excellent product

    By on

    Our vet recommended we give 225 mg of samE and liked that this product also had b vitamins. Her liver enzyme levels have returned to normal.

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