Proin Extended-Release Tablets for Dogs, slide 1 of 1

Proin Extended-Release Tablets for Dogs

Prescription Item

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Strength: 18-mg
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Count: 1 tablet
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Proin Extended-Release is prescribed by your veterinarian to help control urinary incontinence in dogs due to urethral sphincter hypotonus, a weakening of the muscle in the urethra. It works by helping to tighten the bladder and urethral muscles to help prevent urine leaking and accidents. With all the same efficacy as Proin Chewable Tablets, these patented extended-release tablets are designed for once-a-day dosing and deliver a controlled release mechanism for steady absorption.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.


For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.

Possible Side Effects

The following signs have been reported more often with a dose higher than the recommended dosage: agitation, arrhythmia, bradycardia, erythema, fever, hypersalivation, hypertension, lethargy, mydriasis, panting, piloerection, tachycardia, tremor, and urinary retention.

Drug & Food Interactions

No serious food and drug interactions have been reported.


Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that phenylpropanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating. Store Proin ER out of reach of dogs and other pets in a secured location. Instances of dogs chewing through closed bottles of Proin ER and eating the bottle’s contents have been reported. If accidental exposure occurs, consult a veterinarian and notify Pegasus Laboratories (1-800-874-9764)

This item cannot be shipped to Arkansas, Iowa, Louisiana, Oregon, and West Virginia.

Please note product may arrive in a Chewy Pharmacy vial, manufacturer packaging is shown for reference.

These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.

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  1. Prescribing Information

See all items by Proin

  • Item Number
  • Restricted Availability
    AR, IA, LA, OR, WV
  • For Use With
  • Generic Name
    phenylpropanolamine hydrochloride
  • Common Brand Name(s)
    Proin Extended-Release
  • Administration Form
  • Product Form
  • Health Condition
  • Drug Type
    Adrenergic Agent

Proin ER tablets contain 18, 38, 74 or 145 mg phenylpropanolamine hydrochloride per tablet.

Recommended Dosage

The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Do not split or crush tablets. Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg. Dogs may transition from Proin Chewable Tablets to Proin ER without a break in administration. However, do not alternate Proin ER with Proin Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.

Storage Instructions

Store at controlled room temperature 68-77°F, excursions permitted between 59-104°F.


Why Proin ER?

  • Convenient - Given with food, a single dose per day simplifies treatment.

  • Innovative - Patented release technology provides controlled release that ensures steady absorption.

  • Easy to Prescribe - Four dosing strengths based on body weight to provide simplicity.

What are the common clinical signs of urinary incontinence in dogs?

  • Dripping or leaking urine

  • Excessive licking of the genital area

  • Red and irritated skin around the genital area

  • Needing to go more frequently than normal

  • Wetting the bed or sleeping area

  • Urinating inappropriately in the house

Fortunately, while frustrating at first, canine urinary incontinence may be controlled with Proin ER, a safe and effective FDA-approved once-a-day tablet that works by increasing urethral sphincter tone to help prevent urinary accidents.

Rating: 4.3 of 5 stars 78 Reviews 78 Reviews 4.4 out of 5 Stars

95% Recommend

95% of reviewersrecommend this product

Rating: 4.3 of 5 stars 4.4 / 5

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78 Reviews

Showing 1-10 of 78 Reviews

  • 5 out of 5 stars

    Works for my female malamute

    By Epic on Jan 22, 2022

    My large female malamute has been on this for a month now and the difference has been night and day. She was having intermittent loose urinary tract issues that were becoming more and more frequent last fall. I got her to her vet who recommended this and for the month she's been on it, there have been ZERO incidents of her accidentally peeing inside. So far, in the first month, there have been absolutely zero side effects. She eats, plays, and poops/pees like normal. I have a close family relative who is a vet who also highly endorsed this, and has only ever heard good things from owners of animals for which she has prescribed Proin. Highest recommendation.

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  • 3 out of 5 stars

    Proin ER for dogs

    By Lynn on Dec 12, 2021

    I have been using the regular one twice a day for at least a couple years, was told to try this female leaks a lot.. I tried and I'm not seeing any difference unless it takes a couple months to act better in her's more expensive, she's still leaking, so I went back to the old one. If she's gonna leak, then why pay more for the same outcome. Might just be me, and my girl...but my carpets ruined...she's 8 and a Doberman...thats a good size pee stain. I don't know what to do.

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  • 5 out of 5 stars

    Spayed incontinence

    By Cathy on Aug 3, 2021

    Our poor girl started wetting her bed when she just turned 3 yrs. She’s a beautiful black/tan pure German Shepherd rescue and would wake up suddenly when she peed during a nap. Since we only had male dogs we weren’t prepared for this, yet we love her too much, not to do anything to help her. We could read in her eyes that she didn’t like it either and she knows she’s supposed to go outside. We still would have had her spayed even if we had known this could happen. All of our dogs have been ‘fixed.’ As much as I love puppies, we don’t breed our dogs.

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  • 5 out of 5 stars

    Same medication that my vet prescribes

    By Ldropps on Sep 7, 2021

    This is the same medication that my vet prescribes only cheaper. I'm very happy to save some money while knowing that my little one is getting what he needs.

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  • 5 out of 5 stars

    Apprehensive at first. Been using Proin for 10 years.

    By YLab on Jul 15, 2021

    10 years ago our yellow Lab started leaking urine at just 1 year old. It was dog diapers, kept outside 24 hrs a day, or Proin. I read many scary reviews about people's dogs dying from the drug. Well, it worked perfectly for our dog. She's 11 1/2 now and as soon as the Proin ER came out we started it. No leakage ever or problem with Proin or Proin ER. I recommend it.

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  • 5 out of 5 stars

    proin ER is good.

    By dessertno on Aug 10, 2021

    works great, but the way you order is something to be desired! it says '1 tablet, and if you don't pay real close attention, then you get only one pill period in the bottle. duh. why don't you fix this?

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  • 4 out of 5 stars


    By Jfdogowner on Jul 16, 2021

    I was surprised the pills didn’t come in the pictured container. It came in a generic plastic pill bottle. I have to believe it’s the real thing. I’ve also ordered Percortin, this has to be the real thing. My dogs life depends on it.

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  • 1 out of 5 stars

    not impressed

    By 11111 on Aug 6, 2021

    My girl was on this as the original Proin wasn’t available. It did nothing for her incontinence. Thank God the original is now available, 5 straight dry nights so far

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  • 5 out of 5 stars


    By Kokie on Aug 12, 2021

    My order went sailing through the process smooth as silk. Frustration free ordering. The price was lower than I have been paying. Shipping was very prompt.

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  • 5 out of 5 stars

    very pleased.

    By Cookie on Jul 22, 2021

    It was easy to have you contact my vet office for the prescription and it arrived quickly. Hate that my 5 year old baby has to be on medication but it is working for her spay incontinence.

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