Proin Extended-Release Tablets for Dogs


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About This Item
Proin Extended-Release is prescribed by your veterinarian to help control urinary incontinence in dogs due to urethral sphincter hypotonus, a weakening of the muscle in the urethra. It works by helping to tighten the bladder and urethral muscles to help prevent urine leaking and accidents. With all the same efficacy as Proin Chewable Tablets, these patented extended-release tablets are designed for once-a-day dosing and deliver a controlled release mechanism for steady absorption.
Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.
Specifications
Item Number | 216792 |
---|---|
Restricted Availability | AR, IA, LA, OR, WV |
For Use With | Dogs |
Generic Name | phenylpropanolamine hydrochloride |
Common Brand Name(s) | Proin Extended-Release |
Administration Form | Oral |
Product Form | Tablet |
Health Condition | Incontinence |
Drug Type | Adrenergic Agent |
Uses
For the control of urinary incontinence due to urethral sphincter hypotonus in dogs.
Possible Side Effects
The following signs have been reported more often with a dose higher than the recommended dosage: agitation, arrhythmia, bradycardia, erythema, fever, hypersalivation, hypertension, lethargy, mydriasis, panting, piloerection, tachycardia, tremor, and urinary retention.
Drug & Food Interactions
No serious food and drug interactions have been reported.
Precautions
Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that phenylpropanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water. The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.
Store Proin ER out of reach of dogs and other pets in a secured location. Instances of dogs chewing through closed bottles of Proin ER and eating the bottle’s contents have been reported. If accidental exposure occurs, consult a veterinarian and notify Pegasus Laboratories (1-800-874-9764)
Ingredients
Proin ER tablets contain 18, 38, 74 or 145 mg phenylpropanolamine hydrochloride per tablet.
Recommended Dosage
The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Do not split or crush tablets. Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg. Dogs may transition from Proin Chewable Tablets to Proin ER without a break in administration. However, do not alternate Proin ER with Proin Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.
Storage Instructions
Store at controlled room temperature 68-77°F, excursions permitted between 59-104°F.
Why Proin ER?
Convenient - Given with food, a single dose per day simplifies treatment.
Innovative - Patented release technology provides controlled release that ensures steady absorption.
Easy to Prescribe - Four dosing strengths based on body weight to provide simplicity.
What are the common clinical signs of urinary incontinence in dogs?
Dripping or leaking urine
Excessive licking of the genital area
Red and irritated skin around the genital area
Needing to go more frequently than normal
Wetting the bed or sleeping area
Urinating inappropriately in the house
Fortunately, while frustrating at first, canine urinary incontinence may be controlled with Proin ER, a safe and effective FDA-approved once-a-day tablet that works by increasing urethral sphincter tone to help prevent urinary accidents.

These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.
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ReviewsWrite a Review
81 Customer Reviews
Excellent Effectiveness, and Better Packaging at Chewy
I'm very grateful this medicine exists with side effects that are comparatively benign. My senior dog developed urinary incontinence a couple years ago, and this has saved a lot of cleanup trouble as well as helped her stay happy. We could tell she was ashamed and confused whenever she ended up with a puddle around her rear; requiring time & effort, towels, and a quick rinse to tidy up. The only downside is its apparently bad taste. She usually gobbles anything up but will immediately spit these pills out. Fortunately, this is easily solved by pill pockets or non-flaky cheese that we can stuff these into. Chewy's pharmacy makes the experience even better by allowing specific pill counts to save on packaging. I was used to only being able to order 30-count bottles from other pharmacies.
Works for my female malamute
My large female malamute has been on this for a month now and the difference has been night and day. She was having intermittent loose urinary tract issues that were becoming more and more frequent last fall. I got her to her vet who recommended this and for the month she's been on it, there have been ZERO incidents of her accidentally peeing inside. So far, in the first month, there have been absolutely zero side effects. She eats, plays, and poops/pees like normal. I have a close family relative who is a vet who also highly endorsed this, and has only ever heard good things from owners of animals for which she has prescribed Proin. Highest recommendation.
Very pleased with product
My little girl was having issues were she would have accidents at night while she slept, As she sleeps with me, not good. Vet tried the 18 mg and she has be dry ever since. (Me too. :))
Curb the flow
This product has worked wonders in keeping my very old female from leaking urine. Haven't had to shampoo carpets everyother day. Highly recommend this prescription drug.
Proin ER for dogs
I have been using the regular one twice a day for at least a couple years, was told to try this one..my female leaks a lot.. I tried and I'm not seeing any difference unless it takes a couple months to act better in her system...it's more expensive, she's still leaking, so I went back to the old one. If she's gonna leak, then why pay more for the same outcome. Might just be me, and my girl...but my carpets ruined...she's 8 and a Doberman...thats a good size pee stain. I don't know what to do.
Spayed incontinence
Our poor girl started wetting her bed when she just turned 3 yrs. She’s a beautiful black/tan pure German Shepherd rescue and would wake up suddenly when she peed during a nap. Since we only had male dogs we weren’t prepared for this, yet we love her too much, not to do anything to help her. We could read in her eyes that she didn’t like it either and she knows she’s supposed to go outside. We still would have had her spayed even if we had known this could happen. All of our dogs have been ‘fixed.’ As much as I love puppies, we don’t breed our dogs.
Same medication that my vet prescribes
This is the same medication that my vet prescribes only cheaper. I'm very happy to save some money while knowing that my little one is getting what he needs.
Hmmmmmmmm?
I was surprised the pills didn’t come in the pictured container. It came in a generic plastic pill bottle. I have to believe it’s the real thing. I’ve also ordered Percortin, this has to be the real thing. My dogs life depends on it.
proin ER is good.
works great, but the way you order is something to be desired! it says '1 tablet, and if you don't pay real close attention, then you get only one pill period in the bottle. duh. why don't you fix this?
Apprehensive at first. Been using Proin for 10 years.
10 years ago our yellow Lab started leaking urine at just 1 year old. It was dog diapers, kept outside 24 hrs a day, or Proin. I read many scary reviews about people's dogs dying from the drug. Well, it worked perfectly for our dog. She's 11 1/2 now and as soon as the Proin ER came out we started it. No leakage ever or problem with Proin or Proin ER. I recommend it.