Proin Extended-Release Tablets for Dogs
Prescription Item
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Proin Extended-Release is prescribed by your veterinarian to help control urinary incontinence in dogs due to urethral sphincter hypotonus, a weakening of the muscle in the urethra. It works by helping to tighten the bladder and urethral muscles to help prevent urine leaking and accidents. With all the same efficacy as Proin Chewable Tablets, these patented extended-release tablets are designed for once-a-day dosing and deliver a controlled release mechanism for steady absorption.
UsesFor the control of urinary incontinence due to urethral sphincter hypotonus in dogs.
Possible Side EffectsThe following signs have been reported more often with a dose higher than the recommended dosage: agitation, arrhythmia, bradycardia, erythema, fever, hypersalivation, hypertension, lethargy, mydriasis, panting, piloerection, tachycardia, tremor, and urinary retention.
Drug & Food InteractionsNo serious food and drug interactions have been reported.
Precautions
Proin ER may mask signs of incontinence due to urinary tract infection. Proin ER
is not effective in dogs with incontinence due to neurologic disease or malformations. Proin ER may cause hypertension; therefore, use with caution in dogs with pre-existing heart disease, hypertension, liver disease, kidney insufficiency, diabetes, glaucoma, and conditions with a predilection for hypertension. Use with caution in dogs receiving sympathomimetic drugs, tricyclic antidepressants, or monoamine oxidase inhibitors as increased toxicity may result. Use with caution in dogs administered halogenated gaseous anesthetics as this may increase the risk of cardiac arrhythmias. A laboratory study on human blood revealed that phenylpropanolamine (PPA) used in conjunction with aspirin may potentiate decreased platelet aggregation. Proin ER may cause increased thirst; therefore, provide dogs with ample fresh water.
The safe use of Proin ER has not been evaluated in dogs that are intended for breeding, or that are pregnant or lactating.
This item cannot be shipped to Arkansas, Iowa, Louisiana, Oregon, and West Virginia.
These Proin Extended-Release Tablets have the same efficacy as Proin Chewable Tablets.
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Item Number216792
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Restricted AvailabilityAR, IA, LA, OR, WV
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For Use WithDogs
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Generic Namephenylpropanolamine hydrochloride
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Common Brand Name(s)Proin Extended-Release
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Administration FormOral
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BrandPRN Pharmacal
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Product FormTablet
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Health ConditionIncontinence
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Drug TypeAdrenergic Agent
Proin ER tablets contain 18, 38, 74 or 145 mg phenylpropanolamine hydrochloride per tablet.
The recommended dosage is 2 to 4 mg/kg (0.9 to 1.8 mg/lb) of body weight once daily. Do not split or crush tablets. Dogs weighing less than 10 pounds cannot be safely dosed because tablet administration would result in a dose over 4 mg/kg. Dogs may transition from Proin Chewable Tablets to Proin ER without a break in administration. However, do not alternate Proin ER with Proin Chewable Tablets because the effectiveness and safety of interchangeable use have not been evaluated.
Storage InstructionsStore at controlled room temperature 68-77°F, excursions permitted between 59-104°F.
Why Proin ER?
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Convenient - Given with food, a single dose per day simplifies treatment.
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Innovative - Patented release technology provides controlled release that ensures steady absorption.
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Easy to Prescribe - Four dosing strengths based on body weight to provide simplicity.
What are the common clinical signs of urinary incontinence in dogs?
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Dripping or leaking urine
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Excessive licking of the genital area
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Red and irritated skin around the genital area
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Needing to go more frequently than normal
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Wetting the bed or sleeping area
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Urinating inappropriately in the house
Fortunately, while frustrating at first, canine urinary incontinence may be controlled with Proin ER, a safe and effective FDA-approved once-a-day tablet that works by increasing urethral sphincter tone to help prevent urinary accidents.
Customer Reviews
94% Recommend
94% of reviewersrecommend this product
You've Already Reviewed This Item
49 Reviews
Showing 1-10 of 49 Reviews
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Too Strong
By DocD on Jan 7, 2021
I bought 90 of these 74 mg extended release Proin Tablets! They are way too strong! Too many neurological symptoms! The regular 75mg tablets were fine! Why do you keep changing the Proin tablets every time I order? Now I have $74 worth of meds I can’t use!!!! Dr DeMello
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My dog hates the flavor
By Sam13 on Dec 18, 2020
They seem to do the trick for my dog's incontinence however she hates the flavor. They come in a chewable form but she will not eat these and has also been able to detect these in every type of food. I have to pry her mouth open and shove them down her throat which is unpleasant for both of us.
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Help my dog urination issue
By John on Jan 12, 2021
The vet prescribed this medication to help my dog urination inconsistency and I have to say I can see the difference. She is not having accidents after a nap and the price is a lot lower than what the vet is charging.
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Do Not Use
By Kathyb on Oct 5, 2020
My Vet prescribed this for my 8 year old Jack Russell Terrier. She didn't like taking it and we only gave it to her every other day because she would not eat when she got it. It did work for the incontinence. She got it for about 3 months. She lost over 5 pounds and she was only a 20 pound dog. She eventually quit eating. Took her to the Vet. She had an enlarged heart. Got more medicine for that. Within a week she was dead from complete renal failure. I can't say for sure this is what caused her death, but she was at the Vet for her annual physical in March and she was extremely healthy. Please be very cautious using Proin ER! I wish I would have saw a post like this. I would have My Vet prescribed this for my 8 year old Jack Russell Terrier. She didn't like taking it and we only gave it to her every other day because she would not eat when she got it. It did work for the incontinence. She got it for about 3 months. She lost over 5 pounds and she was only a 20 pound dog. She eventually quit eating. Took her to the Vet. She had an enlarged heart. Got more medicine for that. Within a week she was dead from complete renal failure. I can't say for sure this is what caused her death, but she was at the Vet for her annual physical in March and she was extremely healthy. Please be very cautious using Proin ER! I wish I would have saw a post like this. I would have been more aware of what was happening to her. … more
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Proin is great; shipping, not so much
By Melee on Aug 19, 2020
I chose Chewy because of the two-day shipping and because my partner and I being busy people, I didn't realize our girl had run out of her pills, and one of our vehicles was in the shop. When I ordered I forgot that our vet has my partner's name listed instead of mine, so it didn't go through. That's my bad. But when I got the email about it I called immediately, in the middle of the night, bless their hearts. The person I spoke to entered my partner's name in such a way that it looked like HE was the VET and our vet had no idea what was going on I couldn't help. I had to call and be on the phone with Chewy for another 15 minutes or so. We finally got the pills today... 9 days after I ordered I chose Chewy because of the two-day shipping and because my partner and I being busy people, I didn't realize our girl had run out of her pills, and one of our vehicles was in the shop. When I ordered I forgot that our vet has my partner's name listed instead of mine, so it didn't go through. That's my bad. But when I got the email about it I called immediately, in the middle of the night, bless their hearts. The person I spoke to entered my partner's name in such a way that it looked like HE was the VET and our vet had no idea what was going on I couldn't help. I had to call and be on the phone with Chewy for another 15 minutes or so. We finally got the pills today... 9 days after I ordered them. I probably won't get our dogs pills through Chewy again. The experience was pretty bad. Everyone I spoke with was very nice, though. And the proin is pretty much a miracle. … more
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Great product
By Lexi3 on Jan 16, 2021
My male Australian cattle dog mix was has urinary incontinence at night, and since being on tgis medication he has had no inconvenience or side effects.
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Immediately Effective
By GoodStuff on Oct 30, 2020
My grown-up spayed love bucket was leaving little tinkle spots everywhere AND was licking constantly to keep herself clean. To the vet we went where Proin 18 mg ER was prescribed. One dose and she was 100%. I get it from Chewy because it's economical and convenient.
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Proin ER WORKS
By Rudy on Oct 30, 2020
So excited that I was able to purchase this med through Chewy. Their prices can't be beat and their customer service is top notch. So friendly and helpful through the process of getting prescription from my vet. Thanks Chewy.
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Amazing medication!
By Brittni on Oct 4, 2020
This medication is amazing. My dog has urinary incontinence that is not only annoying to me, but also very frustrating for her as she feels like she is in trouble every time she has an accident (I obviously never punish her for them). This medication has worked wonders and helped her get back to her normal goofy self.
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great service
By Sharon on Jan 7, 2021
love the ease of this transaction! This is so much easier than a trip to pick up every month!!
