ProZinc Insulin U-40 for Dogs and Cats, slide 1 of 1

ProZinc Insulin U-40 for Dogs and Cats, 10-mL

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ProZinc is a protamine zinc insulin prescribed by veterinarians to help support the insulin levels of diabetic cats and dogs. It typically effects your pet for 10-14 hours at a time, which helps to keep their blood glucose level consistent throughout the day. It contains recombinant DNA that mimics human insulin, so it helps to control your pet's diabetic symptoms and keeps them comfortable.


For the reduction of hyperglycemia and hyperglycemia-associated clinical signs in cats with diabetes mellitus.

Possible Side Effects

Pet parents should be advised to observe for signs of hypoglycemia. Use of this product, even at established doses, has been associated with hypoglycemia. An animal with signs of hypoglycemia should be treated immediately. Appropriate diagnostic tests should be performed to rule out other endocrinopathies in diabetic cats that are difficult to regulate.

Drug & Food Interactions

Talk to your veterinarian about any other drugs your cat is taking before starting this medication.


Animals presenting with severe ketoacidosis, anorexia, lethargy, and/or vomiting should be stabilized with short-acting insulin and appropriate supportive therapy until their condition is stabilized. As with all insulin products, careful pet monitoring for hypoglycemia and hyperglycemia are essential to attain and maintain adequate glycemic control and to prevent associated complications. Overdosage can result in profound hypoglycemia and death. Progestogens, certain endocrinopathies and glucocorticoids can have an antagonistic effect on insulin activity. Progestogen and glucocorticoid use should be avoided.


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  1. Prescribing Information

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  • Item Number
  • Common Brand Name(s)
  • Generic Name
    Protamine Zinc Recombinant Human Insulin
  • For Use With
    Dogs & Cats
  • Brand
    Boehringer Ingelheim
  • Product Form
  • Health Condition
  • Drug Type
    Insulin, Hormone

Insulin, Protamine Sulfate, Zinc Oxide, Glycerin, Dibasic Sodium Phosphate, Heptahydrate Phenol (added as a preservative), Hydrochloric Acid. Water for Injection (maximum).

Recommended Dosage

The initial recommended ProZinc dose is 0.1 - 0.3 IU insulin/pound of body weight (0.2 - 0.7 IU/kg) every 12 hours. The dose should be given concurrently with or right after a meal. The veterinarian should re-evaluate the cat at appropriate intervals and adjust the dose based on both clinical signs and glucose nadirs until adequate glycemic control has been attained. In the effectiveness field study, glycemic control was considered adequate if the glucose nadir from a 9-hour blood glucose curve was between 80 and 150 mg/dL and clinical signs of hyperglycemia such as polyuria, polydipsia, and weight loss were improved.

Storage Instructions

Store in an upright position under refrigeration at 36° - 46°F. Do not freeze. Protect from light.


What is ProZinc insulin?

ProZinc insulin is an aqueous protamine zinc suspension of recombinant human insulin that is used to reduce hyperglycemia (high blood glucose or high blood sugar) in cats with diabetes mellitus. A licensed veterinarian must prescribe ProZinc insulin for your cat. ProZinc insulin should be given to cats only. Keep out of reach of children. Seek medical attention immediately if you accidentally inject yourself with ProZinc insulin.

What is diabetes mellitus?

Diabetes mellitus occurs when a cat has insufficient levels of, or an abnormal response to, insulin. The low insulin levels may result in high blood glucose that could produce the following changes in your cat:

  • Increased thirst.
  • Increased urination.
  • Increased appetite .
  • Weight loss.
  • High levels of glucose in the urine (glycosuria).
  • Weakness in the back legs.

What kind of results can I expect when my cat is on ProZinc insulin for diabetes mellitus?

Although ProZinc insulin is not a cure for diabetes mellitus, it can help reduce the levels of glucose in the blood, which can help alleviate the clinical signs.

What should I discuss with my veterinarian before giving ProZinc insulin?

Talk to your veterinarian about:

  • The signs of diabetes mellitus you have observed (for example, increased thirst and urination).
  • The importance of proper insulin storage, handling, and administration techniques (for example, how to gently roll the vial prior to each use, the proper appearance of the product after mixing, how to fill the U-40 syringe with the proper amount of insulin, and where and how to inject the insulin).
  • The importance of maintaining the cat under the same conditions for diet, exercise, environment, etc.
  • The importance of follow-up visits for testing to determine if dose adjustments of ProZinc insulin are necessary. Tell your veterinarian about:
  • Any side effects your cat has had when receiving other insulin products.
  • Any medical problems or allergies that your cat has now or has had in the past.
  • All medications that you are giving your cat or plan to give your cat, including those you can get without a prescription.
  • If your cat is pregnant, nursing, or if you plan to breed your cat.

What are the possible side effects that may occur in my cat during ProZinc therapy?

ProZinc insulin, like other drugs, may cause some side effects. Serious side effects can occur with or without warning. Please contact your veterinarian immediately if you think your cat has a medical problem or side effect of ProZinc therapy. The most common insulin-related side effect is low blood glucose (hypoglycemia). Signs of hypoglycemia may occur suddenly and can include:

  • Weakness.
  • Depression, lethargy, sluggishness.
  • Staggering gait.
  • Behavioral changes.
  • Muscle twitching.
  • Seizures.
  • Coma.
  • Death.

What actions do I take if my cat shows signs of hypoglycemia?

  • If your cat is unconscious or having a seizure, this is a medical emergency. Take your cat to the veterinarian immediately.
  • If your cat is conscious, rub approximately 1 tablespoon of corn syrup or honey on your cat’s gums. When it is able to swallow, give corn syrup or honey by mouth until your cat is alert enough to eat. Feed the usual meal and contact your veterinarian.

When should my cat not be given ProZinc insulin?

Do not give your cat its prescribed dose of ProZinc insulin if it:

  • Is experiencing an episode of low blood glucose (hypoglycemia). Common causes for hypoglycemia include excessive doses of insulin, failure to eat, strenuous exercise, changes in the body’s need for insulin, diabetes-inducing disease or drug effects.
  • Is not eating or is vomiting.
  • Is sensitive to protamine zinc recombinant human insulin or any other ingredients in ProZinc product.
  • Do not give your cat its prescribed dose of ProZinc insulin if you see clumps or visible white particles in the vial after gently rolling.

How should I give ProZinc insulin to my cat?

Give ProZinc insulin with U-40 syringes only. Use of a syringe other than a U-40 syringe will result in incorrect dosing. Gently roll the vial until the ProZinc has a uniformly cloudy, white appearance. If there are clumps or visible white particles in the vial after gently rolling, do not use the ProZinc and you’re your veterinarian. ProZinc insulin should be given according to your veterinarian’s instructions. Your veterinarian will tell you what amount of ProZinc insulin is right for your cat and instruct you on techniques for administration.

Can ProZinc insulin be given with other medications?

ProZinc insulin can be given with other medications, but the dose may need to be adjusted due to the medication resulting in either increased or decreased insulin requirements. Tell your veterinarian about all medications you have given your cat in the past, and any medications that you are planning to give with ProZinc insulin. This should include medications that you can get without a prescription. Your veterinarian may want to ensure that all of your cat’s medications can be given together.

What should I do if I inject more than the prescribed amount of ProZinc insulin?

Contact your veterinarian immediately and, if your veterinarian is not available, seek other veterinary advice at once.

What should I do if my cat receives less than the prescribed dose, or I miss an injection?

  • Contact your veterinarian as soon as possible for advice on your cat’s next dose.
  • If you cannot reach your veterinarian and your cat is eating and acting normally, give your cat the usual dose at the next regularly scheduled injection time.

How should I store ProZinc insulin?

ProZinc insulin should be stored in an upright position under refrigeration at 36 - 46°F (2 - 8°C). Do not freeze. Protect from light.

What else should I know about ProZinc insulin?

This sheet provides a summary of information about ProZinc insulin. If you have any questions or concerns about the product or diabetes mellitus, talk to your veterinarian. As with all prescribed medications, ProZinc insulin should only be given to the cat for which it is prescribed and for the condition for which it was prescribed. It is important to periodically discuss your cat’s response to ProZinc insulin at regular checkups that may include blood glucose monitoring. Your veterinarian will best determine if your cat is responding as expected and should continue receiving ProZinc insulin.

66 Reviews 66 Reviews 4.9 out of 5 Stars

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  • 5 out of 5 stars

    Very impressed

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    First time ordering my cat’s insulin and was very impressed with the careful packaging! Always drove 15 miles to my vets office. well no more Thank you Chewy

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  • 5 out of 5 stars

    Wonderful Insulin!

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    This insulin has kept my baby boy kitty alive and healthy for almost a decade. He has never had any diabetic issues since being on this insulin. It is pricy but worth it.

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  • 5 out of 5 stars

    Great Service

    By on

    Received the insulin neatly wrapped in cold packaging just as promised. Will get Jasmine's prescription from Chewy from now on.

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  • 5 out of 5 stars

    My first order in December

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    I was very pleased with the service from you all on my first order. It was there quickly when I needed it.

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  • 5 out of 5 stars

    Great price and great service

    By on

    I was able to get my cat’s insulin from you for much less than direct from my vet and have it automatically shipped so I don’t have to worry about running out. One less thing to worry about! Thanks, Cheey!

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  • 5 out of 5 stars

    ProZinc Insulin

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    Love the price! Love how quickly it arrived too! Whoever writes the labels should double check as mine said take one tablet every 12 hours. This insulin is liquid and is given with a syringe. Other than that...FANTASTIC! I would (and have) definitely recommend for ALL your pet needs.

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  • 5 out of 5 stars

    Arrived as Promised

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    I was worried that the insulin would not be kept cold as required. But when it arrived, it was excellently packed and was as cold as it would be in my refrigerator.

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  • 5 out of 5 stars

    ProZinc Insulin

    By on

    For my cat and a cheaper price than what I have been paying at the vet. Very same thing. They make it very easy by contacting the vet for the script and had it within a day. Great Service. I will be using them when I need it again.

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  • 5 out of 5 stars

    Works for Tigger

    By on

    Price point is the best I’ve found and thankfully the insulin keeps Tigger’s diabetes in check. Chewy’s packed the ProZinc in a styrofoam cooler along with ice packs which were still frozen when the package was opened. Love the door to door delivery!

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  • 5 out of 5 stars

    Good prices and works

    By on

    Works great the price is so so much cheaper than the vet thank you chewy for such good prices especially when your on a budget :-)

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