Revolution Plus Topical Solution for Cats, 5.6-11 lbs, (Orange Box), slide 1 of 1

Revolution Plus Topical Solution for Cats, 5.6-11 lbs, (Orange Box)

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Count: 6 Doses (6-mos. supply)
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Help protect your four-legged friend from pesky critters with this 6-in-1 broad spectrum monthly Topical Solution for Cats by Revolution Plus. Simply apply the quick-drying, small-volume prescription to help: kill fleas before they lay eggs, kill ticks for a full month, prevent heartworm disease and treat and control roundworms, hookworms and ear mites. This topical medication is suitable for cats and kittens eight weeks of age or older, weighing between 5.6 and 11 pounds.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.


Revolution Plus is indicated for the prevention and control of flea infestations, prevention of heartworm disease caused by Dirofilaria immitis, and the treatment and control of ear mite infestations. Revolution is also indicated for the treatment and control of roundworm and intestinal hookworm infections in cats.

Possible Side Effects

Reported side effects in clinical trials included lethargy and anorexia. Use with caution in cats with a history of neurologic disorders. Sarolaner, one of the ingredients in Revolution Plus, is a member of the isoxazoline class, which has been associated with adverse reactions such as tremors, ataxia, and seizures. Reactions have occurred in cats with or without a history of neurologic disorders. 

Drug & Food Interactions

Talk to your veterinarian about any other drugs your cat is taking before starting this medication.


In humans, Revolution Plus may be irritating to skin and eyes.

Dosage Chart

Color on BoxWeight RangeStrengthVolumeDosageProduct Page
Gold2.8-5.5 lbs15 mg Selamectin & 2.5 mg Sarolaner per tube0.25 mLAdminister entire contents of a single dose tube once a month✓-Click Here
Orange5.6-11 lbs30 mg Selamectin & 5 mg Sarolaner per tube0.5 mLAdminister entire contents of a single dose tube once a month✓-Click Here
Green11.1-22 lbs60 mg Selamectin & 10 mg Sarolaner per tube1 mLAdminister entire contents of a single dose tube once a month✓-Click Here

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  1. Prescribing Information

See all items by Revolution

  • Item Number
  • Common Brand Name(s)
    Revolution Plus, Paradyne
  • For Use With
  • Generic Name
  • Administration Form
  • Dosage Measure
  • Lifestage
    Kitten, Adult, Senior
  • Breed Size
    Medium Breeds
  • Product Form
  • Strength
    30 mg Selamectin and 5 mg Sarolaner
  • Health Condition
    Ear Mites, Roundworms, Heartworms, Fleas, Ticks, Hookworms
  • Drug Type

30 mg Selamectin and 5 mg Sarolaner.

Recommended Dosage

Firmly press the cap down to puncture the seal on the Revolution Plus tube; a clicking sound will confirm that the cap has successfully punctured the seal. Remove the cap and check to ensure that the tip of the tube is open. To administer the product, part the hair on the back of the animal at the base of the neck in front of the shoulder blades until the skin is visible. Place the tip of the tube on the skin and squeeze the tube 3 or 4 times to empty its entire contents directly on to the skin in one spot. Keeping the tube squeezed, drag it away from the liquid and lift to remove. Check the tube to ensure that it is empty. Do not massage the product into the skin. Due to alcohol content, do not apply to broken skin. Avoid contact between the product and fingers. Do not apply when the hair coat is wet. Stiff hair, clumping of hair, hair discoloration, or a slight powdery residue may be observed at the treatment site in some cats. These effects are temporary and do not affect the safety or effectiveness of the product. Discard empty tubes in your ordinary household refuse.

Storage Instructions

Store at temperatures between 59-86°F.


How is Revolution Plus different from Revolution?

Revolution Plus builds upon the proven 5-in-1 protection of Revolution, veterinarians’ #1 trusted pest treatment for cats—PLUS it now protects against ticks, too.

With one monthly dose, Revolution Plus broadens the scope of pest protection to 6 common parasites that are harmful for both indoor and outdoor cats and kittens, with unique dual action against fleas and ear mites.

What parasites does Revolution Plus protect against in cats and kittens?

Revolution Plus broadens the scope of protection for cats and kittens, inside and out, against fleas, ticks, ear mites, roundworms, hookworms, and heartworms. Get the 6-in-1 Protection Basics

My cat only lives indoors. Is parasite protection necessary?

Parasites are not outdoor-only. Fleas, ticks, ear mites, intestinal worms, and heartworms can get into any home. Parasites hitchhike indoors on other pets or creatures, on shoes and clothes, or get inside through doors and windows. Cats and kittens of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) can regularly come in contact with parasites and their health risks. With one monthly dose, RRevolution Plusprovides broad-spectrum coverage against common pests that both indoor and outdoor cats need.

How do I apply Revolution Plus to my cat?

Revolution Plus is a simple-to-apply, quick-drying, small-volume, monthly topical solution—so there’s no need to hassle with larger volume topicals or giving your cat a pill!

What are the side effects of Revolution Plus for cats?

The most commonly reported side effects in clinical trials were temporary loss of appetite and drowsiness. No side effects were noted when Revolution Plus was used along with commonly prescribed veterinary products.

While there was a low incidence of side effects in clinical trials, it’s important to report to your veterinarian any unusual signs or activity in your cat or kitten after applying the product.

Is Revolution Plus safe for cats and kittens?

Revolution Plus is proven safe for cats and kittens as young as 8 weeks of age, weighing 2.8 lbs or greater. The safe use of Revolution Plus has not been established in kittens less than 8 weeks old or breeding, pregnant, or lactating cats.

Since one of the active ingredients (sarolaner) in Revolution Plus is a member of the isoxazoline class, use with caution in cats with a history of neurologic disorders such as seizures. Revolution Plus has been administered in conjunction with numerous cat medications and may be given to cats with adult heartworm infection.

How can I decide which pest protection is best for my cat?

It’s always best to talk with your veterinarian about the right protection for your furry friend. But a good start is looking at our comparison chart to see how the Revolution Plus label compares to that of other pest preventatives. Only Revolution Plus provides broad-spectrum, 6-in-1 protection against fleas, ticks (black-legged or deer tick, Gulf Coast tick, and American dog tick), ear mites, roundworms, hookworms and heartworms, with unique dual action against fleas and ear mites.

Are ticks common in cats?

Though certain ticks are more prominent in certain areas (i.e., Gulf Coast tick in Southeastern and mid-Atlantic states; American dog tick east of the Rocky Mountains and Pacific coast; black-legged or deer tick across eastern U.S.), cat owners should be vigilant with year-round tick and other pest protection in all 50 states to ensure cats of all lifestyles (indoor-only, indoor/outdoor, outdoor-only) are properly protected with broad-spectrum preventative medicine such as Revolution Plus.

Where is Revolution Plus manufactured?

Zoetis manufactures Revolution Plus in Kalamazoo, Michigan.

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