Sentinel Flavor Tablets for Dogs, 51-100 lbs, 6 treatments

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Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Sentinel is a monthly oral preventive prescription that protects your pet against heartworms, adult roundworms, adult hookworms, whipworms and prevents the development of flea eggs. Best of all, this medication may also help protect your pal against heartworm disease and intestinal worms, all in a tasty, flavored tablet.


Sentinel Flavor Tabs are formulated for dogs and puppies, four weeks of age and older, and two pounds body weight or greater. It is also formulated to help prevent and control flea populations, and for the treatment and control of adult roundworm, hookworm and whipworm infections. Concurrent use of an adulticide product may be necessary for adequate control of adult fleas.

Possible Side Effects

The following adverse reactions have been reported in dogs alter giving Milbemycin Oxime or Lufenuron: vomiting, depression/lethargy, pruritus, urticaria, diarrhea, anorexia, skin congestion, ataxia, convulsions, hypersalivation, and weakness.

Drug & Food Interactions

Talk to your veterinarian about any other drugs your dog is taking before starting this medication.


Do not use in puppies less than four weeks of age and less than two pounds of body weight. The temporary use of a product for adult fleas may be necessary to kill them. Not for use in humans. Keep this and all drugs out of the reach of children.

  1. Prescribing Information

See all items by Sentinel

  • Item Number
  • Common Brand Name(s)


  • Generic Name

    Milbemycin Oxime, Lufenuron

  • Dosage Measure

    Use according to your veterinarian's instructions.

  • For Use With


  • Brand


  • Breed Size

    Medium Breeds, Large Breeds

  • Product Form


  • Health Condition

    Heartworms, Roundworms, Hookworms, Whipworms, Fleas

  • Drug Type



Milbemycin Oxime, Lufenuron.

Recommended Dosage

Sentinel Flavor Tabs are given orally, once a month, at the recommended minimum dosage of 0.23 mg/lb (0.5 mg/kg) milbemycin oxime and 4.55 mg/lb (10mg/kg) lufenuron. To ensure adequate absorption, always administer immediately after or in conjunction with a normal meal.

The chewables should be administered in a manner that encourages the dog to chew, rather than to swallow without chewing. Chewables may be broken into pieces and fed to dogs that normally swallow treats whole. Care should be taken that the dog consumes the complete dose, and treated animals should be observed a few minutes after administration to ensure that no part of the dose is lost or rejected. If it is suspected that any of the doses have been lost, redosing is recommended.

Heartworm Prevention: Sentinel Spectrum should be administered at monthly intervals beginning within 1 month of the dog’s first seasonal exposure to mosquitoes and continuing until at least 6 months after the dog’s last seasonal exposure. Sentinel Spectrum may be administered year-round without interruption. When switching from another heartworm preventative product to Sentinel Spectrum, the first dose of Sentinel Spectrum should be given within a month of the last dose of the former product.

Flea Treatment & Prevention: Treatment with Sentinel Spectrum may begin at any time of the year, preferably starting one month before fleas become active and continuing monthly through the end of flea season. In areas where fleas are common year-round, monthly treatment with Sentinel Spectrum should continue the entire year without interruption. To minimize the likelihood of flea reinfestation, it is important to treat all animals within a household with an approved flea protection product, as necessary.

Intestinal Nematode & Cestode treatment and control: Dogs may be exposed to and can become infected with roundworms, whipworms, hookworms, and tapeworms throughout the year, regardless of season or climate. Clients should be advised of appropriate measures to prevent reinfection of their dog with intestinal parasites. Because the prepatent period for E. multilocularis may be as short as 26 days, dogs treated at the labeled monthly intervals may become reinfected and shed eggs between treatments.

Storage Instructions

Store in a dry place at controlled room temperature between 59° - 77°F.


How are Sentinel Spectrum and Sentinel Flavor Tabs different from other heartworm medications?

Not all heartworm medicines provide the same spectrum of parasite protection. Sentinel Flavor Tabs are chewable tablets that protect dogs against fleas, heartworms, roundworms, hookworms, and whipworms. Sentinel Spectrum is a soft, beef and bacon flavored chew that adds tapeworm protection to offer the broadest coverage available.

My dog weighs more than 100 pounds. Are Sentinel Specturm or Sentinel Flavor Tabs a good option for him?

Yes. Talk to your veterinarian about the appropriate dose for your pet.

My dog is a toy breed. Are Sentinel Specturm or Sentinel Flavor Tabs okay for his small size?

Yes. Both Sentinel Specturm and Sentinel Flavor Tabs offer a size that can be given to small dogs. Sentinel Spectrum has a size available for dogs weighing from 2–8 lbs and Sentinel Flavor Tabs has a size available for dogs weighing from 2–10 lbs.

I see a few fleas on my dog. Is the medication working?

You may see an occasional “hitchhiker” adult flea that your dog has picked up at the dog park or in the yard or other infested environments where 95% of the flea population lives in the form of eggs, maggot-like larvae, and pupae. Sentinel Specturm and Sentinel Flavor Tabs put an end to fleas before they become adults. You may need an adulticide, such as Effitix Topical Solution for Dogs, to treat occasional adult fleas.

Can I give either Sentinel Spectrum or Sentinel Flavor Tabs to my cat?

No, both Sentinel Spectrum and Sentinel Flavor Tabs are only approved for use in dogs.

Customer Reviews
30 Reviews 30 Reviews 4.8 out of 5 Stars

97% Recommend

97% of reviewersrecommend this product

4.8 / 5

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Showing 1-10 of 30 Reviews

  • Know how this may affect your dog!

    By on

    I thought this product would be great for my 2 pit/mix dogs. WRONG!!! My pit/shepard mix did not react well. Vomiting, lethargy, depression. Common in many breeds, but the Chewy questionnaire didn't catch it. The Sentinel company doesn't list the breeds that are hypersensitive to this medication. Do your homework! I should have done more homework!!

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  • Healthy Rotties

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    My Rottie girls are big and healthy due to this excellent product. No positive tests for parasites and no fleas. Living in Florida, this is a must have for my furbabies. No upset stomach or loose stools, that I had with another product. I'm happy, they are happy and healthy.

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  • Will not use anything else

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    I love Sentinel. Yes, it is more expensive than other heartworm meds such as Heartguard, but it also protects against more parasitic worms, as well as fleas, and prevents flea larvae from spreading! In my opinion it is well worth the price difference!!!

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  • Sentinel Works!

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    We have been giving Sentinel to our dog and have not had any issues with heartworm. So far, we highly recommend this product and ordering it from Chewy. Chewy made the prescription verification process painless and sent our items immediately!

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  • Tablets work for us.

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    The tablets work for us in keeping my 70 lb. poodle healthy. But as far as they are a "flavor tab" goes, he will not chew them up. But they are a symmetrical shape and smooth so he lets me toss them to the back of his tongue, stroke this throat to make him swallow, and then get his treat.

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  • Product perfect, packaging took away a star

    By on

    As always, your products and shipping time are perfect. However in this case, my first time trying your pharmacy, I had a concern. The box you shipped it in, was not sealed very well at all. Box was fine, the tape was firmly sealed across the top, but not when it came to the tape needing to adhere to the sides. They were done with a gap! I was able to reach in through that gap and retrieve the medicine!

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  • prescription meds

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    Have been using this product for 3 years, but it's so expensive from the vets, and other online pharmacies have been difficult to deal with. After an initial hiccup with the prescription not being received, the tablets were shipped straight away and arrived very quickly. And so much cheaper

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  • great tablets for my dog

    By on

    Came quickly and Chewy got in touch with my vet right away. I even chatted on their live chat, and they were very knowledgable and helpful. Thanks again! I will continue to keep ordering through Chewy.

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  • Great Product

    By on

    Vet recommended this product and it’s good. No side effects, I used to have my dog on anther heartworm medicine and it would give him the runs for two days, this one nothing..I’m a pleased dog mom.

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  • Complete Protection

    By on

    My retired racing Greyhound Gary is now protected from Heartworm, Fleas, Hookworm, Roundworm, and Whipworm. Our Greyhound is also a donor to a K-9 Blood Bank in Chicago

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