SILEO Oromucosal Gel for Dogs, 0.09 mg/mL, 3 mL -

Sileo Oromucosal Gel for Dogs, 0.09-mg/mL

By Sileo
Rated 4.5221 out of 5 stars
Prescription Item

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About This Item


Sileo (dexmedetomidine oromucosal gel) is the first and only FDA-approved treatment for dogs that suffer from noise aversion. This medication is prescribed by your veterinarian to help calm your dog when your pet is frightened by loud noises. Common noise aversion triggers include fireworks, thunder, construction work, traffic or street noise, celebrations, vacuum cleaners and smoke detectors. Sileo works by blocking norepinephrine, a brain chemical similar to adrenaline that pumps up anxiety.

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Learn More About Sileo From Our Team of Experts

ReviewsWrite a Review

Rated 4.5221 out of 5 stars
113 Reviews
Would recommend to a friend

113 Customer Reviews

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Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 4 out of 5 stars
By Zane on Feb 19, 2023

Calms Terrors & Tremors

We have one dog that is absolutely petrified of storms & thunder. This Sileo Gel is pricey, so we only use it when there are really bad storms visible on radar, but it works wonders and relatively quickly. I would have given five stars, but we had another dog equally as scared of storms that would throw up immediately after ingesting the sileo gel. I still recommend giving the product a try if your dog is terrified. Just keep a close eye on your pet after use to ensure there is no reaction to the product. PS...we also use on the 4th of July to minimize reaction to fireworks.

Rated 5 out of 5 stars
By Diane on Jan 1, 2023

Changed my dogs life

This product has improved my 9-year-old dog's quality of life. Pierre has severe anxiety and by that I mean not just fireworks but whenever a fly comes into the house or I wash dishes or I put my dishes away or there's a rainstorm or the wind. It goes on and on. He's on trazodone and that helps take the edge off but nothing works like this new product, Sileo. Trust me I've been searching for answers for 9 years and he's been on everything from tranquilizers, CBD, anti depressants hormone plugins and so on. I'm grateful for Sileo.

Rated 1 out of 5 stars
By doggiemom on Dec 29, 2022


I used to use this product for my 11lb chihuahua and it used to work really well because it would just knock him out or really drug him up to not shake during loud noises. But I had to stop using it due to an incident where he had peed, pooped, and he couldn't lift himself up and was having problems breathing. This lasted about 10 minutes and when I had put him in the car to go to the ER he was suddenly better. But after that scary moment I had to say no to this product.

Rated 5 out of 5 stars
By Gben on Jan 2, 2023

Sileo is part of our regime to help anxiety

We use sileo in conjunction with other anti anxiety meds for our over reactive dog. We also crate her in a dark room during thunderstorms and fireworks. Seems to work.

Rated 5 out of 5 stars
By Layla on Aug 27, 2022

Really works!

My 12-year-old female dog Layla has a terrible time with fireworks and thunderstorms. They recommend that you are careful with the dosage so that you don't overdose your pet. This medicine is a gel that comes in a syringe that you put in the pocket of their mouth so they don't swallow it. It has a easy dosage system on it and worked right away with my dog on the 4th of July she went to sleep during the All Night fireworks. Best thing I found for noise aversion.

Rated 5 out of 5 stars
By KimC on Nov 2, 2022

It works!!!

This is great stuff! It works fast and lasts a few hours. My main use is thunderstorm anxiety for my Mini Aussie. Prescription meds didn't work. This is great stuff!!

Rated 5 out of 5 stars
By Newtsy68 on Jul 14, 2022

It's the STUFF!!!

So very thankful my vet prescribed this. July 4th has always been such an anxious time for my husky and in turn for me. Sileo really helped my boy this year. Our town has a fireworks display at 10pm each year. I gave him a dose at 8:45pm and by 10pm the medication was working. Our house has the perfect view of the town display but that also means that we get the full effect of it...booms and all. Sileo helped Kimon to weather the noise without such heightened fear and trying to hurt himself (and me). This year with Sileo, my boy laid on the floor in the living room and just lifted his head when there was an especially loud boom. I love how Sileo doesn't drug him. He seemed so relaxed but not out of it. I wish it lasted longer than 2-3 hours but I am very happy with the results this year. Sileo saved us! Highly recommend!

Rated 5 out of 5 stars
By Patsy on Jul 23, 2022

What a relief!

My brother in law has been using this product for years with his small dog. I have seen it work for thunder and fireworks. Our latest rescue has acute hearing and is also terrified of thunder and fireworks. Thunderstorms have been a daily occurrence in Florida this time of year, maybe even worse than we remember. It worked first time. We actually reduced the dose to one dot and that is working almost daily. Easy to measure proper dose based on weight and follow instructions to get the gel dispensed from this syringe like dispenser. Must not let dog swallow so you hold dog’s snout while inserting down into sulcus between cheek and gum. Very quick acting to calm him down unlike a pill. Very pleased we knew of this product.

Rated 5 out of 5 stars
By Karen on Nov 11, 2022

Outstanding results

This product works so well--calms my dog without making her groggy. She just snoozes through the storm with no lasting effects.

Rated 5 out of 5 stars
By Twofluffybums on Jul 15, 2022

Worked great!

We used Sileo over 4th of July weekend and during a thunderstorm for our Bernie/Newfie who is terrified of both events. He is on daily anxiety meds for noise aversion, but when it storms badly or with fireworks he is still a mess. He will be so scared he throws up, pants, paces and shakes. The Sileo calmed him down within 10-15mins and kept him calm throughout the noise event. We used the lowest dose recommended by our vet and it worked perfectly. We have tried lots of other meds and therapies with no success for him, this was our last hope and it worked.