Simparica Chewable Tablets for Dogs, 44.1-88 lbs

Prescription Item

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    $32.87 (32%)

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Count: 6 treatments
  • 3 treatments In stock
  • 6 treatments In stock

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Say goodbye to pesky, persistent pests and hello to Simparica. This once-a-month tablet gives you an easy, reliable way to protect your dog from fleas and ticks. It's a tasty tablet that works to shield your pet for a full 35 days, killing fleas before they can lay eggs. It helps to prevent home infestations and tick-borne illnesses. Plus, unlike other medications, Simparica doesn't need to be given with food. Simply feed him one chewable tablet, just like a monthly treat, and give your companion the broad-spectrum protection he deserves.


Simparica kills adult fleas, and is indicated for the treatment and prevention of flea infestations, and the treatment and control of tick infestations from lonenstar ticks, Gulf Coast ticks, American dog tick, black-legged ticks and brown dog ticks for one month in dogs 6months of age or older and weighing at least 2.8 pounds.

Possible Side Effects

The most frequently reported adverse reactions were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications to the use of Simparica.


Simparica is for use only in dogs, 6 months of age and older. Simparica may cause abnormal neurologic signs such as tremors, unsteadiness, and/or seizures. Simparica has not been evaluated in dogs that are pregnant, breeding or lactating. Simparica has been safely used in dogs treated with commonly prescribed vaccines, parasiticides and other medications. The most frequently reported adverse reactions were vomiting and diarrhea. See full Prescribing Information.

  1. Prescribing Information

See all items by Simparica

  • Item Number
  • Dosage Measure

    Use according to your veterinarian's instructions.

  • Generic Name


  • Common Brand Name(s)


  • For Use With


  • Brand


  • Breed Size

    Medium Breeds, Large Breeds

  • Product Form

    Chewable Tablet

  • Health Condition

    Fleas, Ticks

  • Drug Type



Sarolaner, Hydrolyzed Soy Protein, Starch, Corn, Wheat Germ, Anhydrous Dibasic Calcium Phosphate, Corn Syrup, Gelatin

Recommended Dosage

Simparica is given orally once a month at the recommended minimum dosage of 0.91 mg/lb (2nmg/kg).

Storage Instructions

Store at or below 86°F.

Simparica can be offered by hand, in the food, or administered like other tablet medications.

Care should be taken that the dog consumes the complete dose, and treated animals should be observed for a few minutes to ensure that part of the dose is not lost or refused. If a dose is missed, administer Simparica and resume a monthly dosing schedule.

Simparica should be administered at monthly intervals.

Flea Treatment and Prevention: Treatment with Simparica may begin at any time of the year. In areas where fleas are common year-round, monthly treatment with Simparica can continue the entire year without interruption.

To minimize the likelihood of flea reinfestation, it is important to treat all dogs and cats within a household with an approved flea control product.

Tick Treatment and Control: Treatment with Simparica can begin at any time of the year.


How Does Simparica Work?

Simparica is a great tasting chewable tablet given orally once a month. It travels in your dog's blood to safely deliver persistent continuous protection against fleas and ticks from day 1 to day 35.

Why protect against fleas and ticks?

Tick-borne diseases represent a widespread and growing public health hazard to dogs (and their human companions), causing debilitating illness and even death. It only takes one tick to spread disease, so continuous protection is critical to help reduce the risk of infection.

Likewise, it only takes a single "pregnant" flea to start an infestation on a dog or in a home. And although fleas are largely perceived as a mere nuisance, they too, can pose health risks to pets and humans.

Customer Reviews
32 Reviews 32 Reviews 4.7 out of 5 Stars

94% Recommend

94% of reviewersrecommend this product

4.7 / 5

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Showing 1-10 of 32 Reviews

  • Thank You!

    By on Top 1000 Contributor

    I can't speak highly enough about this! My dog has been on topicals her whole life then once we moved in to this new complex, her treatment suddenly stopped working. She developed a severe flea allergy which then led to skin infections. I was skeptical at first using oral tablets but my vet insisted we give this a try. Within just a couple of weeks, the fleas disappeared! It's been 3 months and we haven't seen one since. Ordering online was super easy too. My vet loves working with Chewy and happily approved the order right away. :)

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  • Our Dog Likes Simparica Chewables

    By on

    Our 13-year-old Sheltie has been taking on a flea/tick preventive her whole life, and when our veterinarian switched her to Simparica Chewables, she thought she was being given a yummy treat instead of medicine. We were so happy to be able to get this from Chewy and save money. We love Chewy’s great service and lower prices!

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  • No more Frontline

    By on

    I switched from Frontline to Simparica a few months ago. It is much easier to give to my dog by mouth rather than the liquid Frontline on his back. He did not like having the Frontline applied and would always try to avoid it. Simparica has been very effective so far.

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  • Highly recommended

    By on

    I've been buying Simparica for my boys for about two years now. In that time I've found a few ticks in their fur (just sitting there hadn't bit them) and two ticks that had attached. Both attached ticks were dead and were easy to pull out in entirety. Great product that makes me feel better about living so close to the woods. Also, there's a reward program through zoetis

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  • It just works!

    By on

    I live in Florida where fleas and ticks can be pretty bad. I was using Bravecto which works just fine but with three dogs in the 44 - 88 pound range that's north of $150 every month even with Chewy's good prices. Looking for an alternative that still provided the protection the boys needed I tried (and switched to) Simparica about a year ago. Haven't seen a single flea or tick on any of the boys before or after.

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  • No fleas, ticks, or vomit.

    By on

    I’ve used comfortis for years with my older dog without issues. My younger one couldn’t tolerate it and would throw it up within an hour so we had to try something else. Both tolerated this one fine and no fleas or ticks found yet.

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  • reviewed product

    By on

    Have been using this product for our dog and all through spring, summer and fall, he did not have any pests on him at all. He goes outside and lays in the yard and we live in a rural area where other animals (coyotes, raccoons, etc) come into our yard at night. good product

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  • Huge price difference

    By on

    The vet actually recommended this and have been purchasing it thru them...NOT anymore...I've been paying way too much for it at the vets...Thank you Chewy for being more reasonable on your prices. WOW BIG difference in prices.

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    By on


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  • OK medicine so far

    By on

    Dog tolerated the medicine so far (2 weeks since the dose). No ticks, no side effects. Chewable tablet that, once I broke it in two, the dog chewed easily. Chewy people were very efficient filling the order.

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