Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box)

By Simparica Trio
Rated 4.6591 out of 5 stars
Prescription Item
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Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 6
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Simparica Trio Chewable Tablet for Dogs, 5.6-11.0 lbs, (Purple Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 6

$148.34Chewy Price
$140.92Autoship Price
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About This Item

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 5.6 and 11 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here

About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
Shop Simparica Trio

ReviewsWrite a Review

Rated 4.6591 out of 5 stars
88 Reviews
Would recommend to a friend

88 Customer Reviews

Rated 5 out of 5 stars
By sabb on Jul 19, 2022

Easy to give and my dog has no side effects

Was very easy to give and my dog takes the tablet and chews it right up. Have not had any side effects from it and the fact that you don't have to buy 3 different products because one tablet takes care of it all.

Rated 5 out of 5 stars
By TnTYorkies on Jul 7, 2022

TOO many pills

We love Chewy but somehow got 2 separate orders and of course were charged for 2 orders -- all on the same day. We will use them but not exactly ready to put out that much cash all at once. But we will certainly continue using Chewy ! Love it !

Rated 2 out of 5 stars
By Fleas on Jul 23, 2022

Going back to our old meds

Used to use Sentinel and Nexgard for heartworms and fleas. Switched to this a few months ago because it was more economical. I've seen 2 fleas ON ME today. Going back to the old stuff that works!

Rated 5 out of 5 stars
By Nancy on Jun 4, 2022

Simparica the best!

This is the best because it’s one treatment for All. My puppy can chew the pill as well. I’m very thankful that this type of treatment for fleas, ticks, and heart worms is available. Now I don’t have to remember what to buy, it’s all right there in one pill!

Rated 5 out of 5 stars
By mchpearland on Jul 23, 2022

Tried and true

I have given my dog Simparica Trio for several years, on the advice of the veterinarian. He has had none of the problems that it prevents.

Rated 1 out of 5 stars
By tickattracter on May 23, 2022

garbage product

I have my 9 pound dog the pill and she ate the whole thing. A few days later we ran in the park and found at least 18 ticks on her!!!! They were all over. This pill did absolutely nothing and maybe even made it worse cuz I never heard of a dog getting over 16 ticks at once!!!!!!!!

Rated 5 out of 5 stars
By jayc on May 2, 2022

Covers All The Bases!

I used to give my dog Sentinel and Bravecto, which worked fine. But, switching to Simparica has been WAY EASIER because it is just the one pill every month. The most challenging part of having two meds was that one was monthly and the other was every six weeks and I would forget one of them... This is SO MUCH BETTER!

Rated 5 out of 5 stars
By DotWallace on May 19, 2022

flea/tick meds.

You sent me tablets. I was under the impression the med was in the form that is applied to the back of the neck. I cannot comment on its effectiveness as it has only been 2 days since pup had pill

Rated 5 out of 5 stars
By Dee1 on Apr 5, 2022

Life made easy

I was hesitant about ordering meds online especially since these require a prescription which Chewy needed to obtain from my veterinarian. I was pleasantly surprised at how quickly Chewy responded to my order. They contacted my vet within one day of placing my order, and I received the meds shortly thereafter. Will definitely be using Chewy again.

Rated 5 out of 5 stars
By Honey on Jul 26, 2022

Great service

They were friendly and helpful with changing my address and everything arrived on time!