Simparica Trio Chewable Tablet for Dogs, 22.1-44.0 lbs, (Teal Box)

By Simparica Trio
Rated 4.3898 out of 5 stars
Prescription Item

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$175.99Chewy Price
$167.19Autoship Price
(Save an extra 5%)

Why Autoship?

  • Save 5% on all future Autoship orders
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In Stock
FREE delivery
Usually arrives in 3-5 days
We'll collect your pet's prescription information at Checkout.

This item requires prescription approval.

Medications ship separately. Delivery times may vary.

Frequently Bought Together

About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 22.1 and 44 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

About Simparica Trio for Dogs

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.

ReviewsWrite a Review

Rated 4.3898 out of 5 stars
254 Ratings
Would recommend to a friend

248 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 3 out of 5 stars
By meg on Sep 14, 2023

Love Chewy

I love this product but it is expensive and my vet will not send order to chewy they want you to order thru them I have to get a prescription and I don't have a fax so I have to pay for that and the gas so there goes any savings not sure what to do

Rated 5 out of 5 stars
By bland on Sep 21, 2023


My basset hound just turned a year old 3 days ago, and she has been on Simpirico Trio since she was 8 weeks old and I have NEVER seen a flea or tick on her! This stuff work GREAT!!

Rated 4 out of 5 stars
By SonomaGirl on Aug 8, 2023

Winslow is Protected

My vet recommended that I try Simparica Trio in lieu of the two separate monthly medications I had previously given my dog Winslow. The price (with a 30% off coupon I had received from Chewy) made the offer inviting and I am confident he will be protected all month long.

Rated 5 out of 5 stars
By Kaitlyn on Jun 25, 2023

Dogs likes them and works well!

We recently switched to this at the recommendation of our vet, we used to do two different medications for heart worm and flea/tick prevention. I looked into it to see others experiences, the side effects, warnings. It was overall highly rated and many people had no issues with giving this medication to their dog. My dog has been taking it for almost two years now, she has never had any issues or side effects. She has tolerated the medication well and takes it easily with or without a pill pocket. I’d recommend this medication if there is a veterinarian recommendation and supervision to ensure your dog is okay to take this, as every dog (like humans) are different with medication/side effects/precautions.

Rated 5 out of 5 stars
By Fancymoma1 on Jul 2, 2023

No more worries over ticks

My cockapoo was a tick magnet with other oral medications. I’m extremely satisfied with Simparica Trio because he hasn’t had any ticks on him since we started this medication about 2 years ago. No side effects and he always gets a clean bill of health from his vet. I do have to crush the pill and mix it in his The Farmers Dog food because he will not eat this pill, even if I put it in a pill pocket. Love the convenience and pricing Chewy provides.

Rated 2 out of 5 stars
By MarcusRefusius on Sep 11, 2023

Just because you CAN doesn’t mean you SHOULD

Like so many Medicines in the US this is WAY overpriced. Taking advantage of people is in no way admirable. I guess we’ll end up buying THIS from another country as well.

Rated 5 out of 5 stars
By Detektiv on Jun 21, 2023

I love this product; my dog doesn't

The "palatable liver flavor" advertised by Simparica does not appeal to my dog. Nothing I have tried to mask the smell/flavor gets her to eat it willingly, so I shove the pill down her gullet every month (fortunately, she doesn't fight me or clamp down like our last dog did!). But so far we have seen no adverse effects, though the multiple reviews mentioning such problems are certainly concerning. That said, this is such a convenient product -- worm, flea, and tick control in one monthly dose -- that we will keep using it. Chewy makes it easy and affordable to order!

Rated 5 out of 5 stars
By Jade on Jun 27, 2023

Great product

Yes, Simpatico Trio is the best. I took my Yorkie to the groomer, and she found a tick on his back leg that had died. It did make a red ring around his leg however, he did not get infected by the tick. I also really haven't taken him to where there is long grass or fields of grass. So he got that tick just from walking locally. Please, protect your beloved animals dogs with this product. Good luck

Rated 1 out of 5 stars
By Beth on Jul 12, 2023


I read all the reviews and thought "my purebred with no family history of any health problems, won't have an issue" but she had a seizure this morning after two months taking this medicine. After confirming with breeder that there is no family history, my vet and I believe it was caused by this medicine! Save your baby, and yourself, the trauma!

Rated 5 out of 5 stars
By Baileymom on Aug 31, 2023

So convenient!

Chewy contacted our vet for Bailey’s prescription and shipped it directly to us. The whole process was super easy and the price was less than the vet was charging us.