Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box)

By Simparica Trio
Rated 4.5672 out of 5 stars
Prescription Item
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Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. supply) slide 1 of 7
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Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box), 12 Chewable Tablets (12-mos. supply) slide 1 of 7

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$316.04Chewy Price
$336.82Chewy Price
$300.24Autoship Price
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About This Item

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 44.1 and 88 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here

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About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.5672 out of 5 stars
238 Reviews
Would recommend to a friend

238 Customer Reviews

Rated 5 out of 5 stars
By Trio on May 5, 2022

The easy med

I live in the Ozarks of MO and the ticks are vile, it pained me for 2 yrs trying to figure out the best treatment for my pups. We tried collars, they helped a little and oils but the deciding factors to going with the trio was every fall we had tick eggs you could see on our hardwood flooring, that was the deal breaker. Since starting the trio, if we did fine a tick it was dead . The bonus is Chewy will deliver the monthly supply, one tablet and my babies are tick free for the month, no more pulling the vile creature each evening or countless baths, oh and another benefit, heart worm , hook worm and fleas covered .

Rated 1 out of 5 stars
By chris on Apr 16, 2022

terrible product

I have a 100 lb German Shephard. He will not eat these under any circumstances. Tried using cheese, breaking them up into small pieces, he hates them. To make matters worse, the packaging is hard to open and the pill itself is huge! After trying to get him to eat these things with diminishing results for 3 months, now he completely refuses. Calling the vet Monday to go back to the small pills and flea collar

Rated 5 out of 5 stars
By Benjamin on May 11, 2022

exceptional product

Obviously no dog is going to voluntarily eat a quarter sized pill but if you are experienced with encouraging the pill down your dogs throat that won’t be a problem. My dog is 1.5 y/o boxer mix and has been taking simparica since day one 10/10 with Texas heat

Rated 5 out of 5 stars
By Christiaan on Apr 25, 2022

Good product.

My property has sandy soil and is heavily wooded so fleas and ticks are a real problem. This product works great, as all three of my dogs are always playing in the woods. I check my dogs frequently and have seen no fleas on them, and any tick I’ve found on them has been dead.

Rated 5 out of 5 stars
By Willow on Apr 21, 2022

Simparica Trio

The price was very reasonable compared to my vet prices. This is our second year using this product and we are very satisfied. We did have issues in receiving the product. It took about two weeks to get the Simparica delivered to us which got our dogs off their schedule. .

Rated 5 out of 5 stars
By JynJ on Mar 26, 2022

Great Product Fair Price!

Our pup (65lb golden doodle) eats this up with no problem. She has a bit of a sensitive tum usually so I’ll have to report back if I make the correlation of loose bowel after. I have noticed some folks on here mentioning the price being “too much”. Here is a different perspective: If you bought three separate pills (one for flea protection, one for tick protection, one for heart worm and hook worm protection) and given that there is a 6 month supply and they’re only charging $168… that’s roughly $9.33 per “pill” or per each protection. Seems more than fair, and reasonable to me.

Rated 5 out of 5 stars
By KTom on Apr 11, 2022

Great product

This was recommended by my vet and has worked well. No fleas and my GSD is happy to take it. It doesn’t upset her stomach and protects against heart worm as well. We are very happy with this product and will continue to use it.

Rated 5 out of 5 stars
By Tim32021 on Apr 13, 2022

I love this medicine

I love when mom gives me this medicine once a month. Not sure why I can't have it more. She told me her other puppies have taken it while they were here with no problems for almost 25 years. As a rescue I am happy I found a family that cares and doesn't make me take multiple meds to get the job done. I am now 65 lbs and 2 years old.

Rated 5 out of 5 stars
By Nancy on May 15, 2022

Excellent Item

Highly recommend these for all furr-doggies (heartworm preventative and kerp off fleas and tics! Although, would be nice if they were cheaper!

Rated 5 out of 5 stars
By Stacey on Apr 27, 2022

LOVE this product

My vet recommend this for my puppy and I’m very happy I went with it! It’s everything you need in one pill (super easy) and a 6 month supply ( even ) definitely recommend