Simparica Trio Chewable Tablet for Dogs, 44.1-88 lbs, (Green Box)

By Simparica Trio
Rated 4.3058 out of 5 stars
Prescription Item

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$99.48 Chewy Price
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$94.51Autoship Price

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Usually arrives in 3-5 days
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Medications ship separately. Delivery times may vary.

About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 44.1 and 88 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer. One count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag.

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Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

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About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.3058 out of 5 stars
788 Ratings
Would recommend to a friend

695 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Teresa on Nov 25, 2023


This product was determined to be the cause of seizures in my beautiful boy Max. He was a 5 year old black lab. He started having seizures the first week on this medication. Our vet treated him as best as they could and he was able to stay with us for one more year. Our vet reported Max to the manufacturer. Although we never received any type of condolences from the manufacturer, they did start airing their commodity the disclaimer that the medication “may cause seizures”. Too late for my Max though!

Rated 5 out of 5 stars
By Leanna on Dec 3, 2023

Simparica Trio has been amazing!

My boy, who is a German Shepard acquired fleas for the first time and was miserable. I called his new vet and they did not carry Simparica but said I could order off of chewy. Chewy was so fast and contacted the vet the next day (a monday) vet approved it and I got it that week. Simparica works immediately and my boy has had zero side effects. He stopped itching about two days after taking it and haven't found one flea on him since.

Rated 5 out of 5 stars
By Willow on Nov 8, 2023

A superhero force field!

If you think all flea pills are created equal-think again. This chewable is the holy grail! I spent a week visiting my parents, they have an ancient dog and took in a kitten. They always used frontline or some other off brand flea and tick tx. Well imagine my surprise when I notice their dog is covered in fleas and has a tapeworm! I immediately went into panic mode. Bathing, combing, vacuuming, and sent my dad out for home and yard sprays. After the initial clean I finally sit and inspect my own dog who had been on simparica trio for 4 months. Not a flea in sight. We take my parents dog to the vet and sure enough they recommended simparica trio. I spent another 5 days at their house and took my dog to the vet after leaving just to be extra safe. She spent almost 2 weeks in a house and yard with fleas and not a single one was able to hitch a ride on her. Buy this now-it’s worth every single penny.

Rated 5 out of 5 stars
By Carol on Nov 13, 2023

Observation about comments

First I have no problem with Simparica Trio. My dog takes it willingly and I have not seen a single tick on her since she started it. And believe me my husband gets loaded with them when he is outside working on our farm. She's never had fleas either but I always look just in case. I have noticed though comments of people are saying they have to put the pill in the back of their pets throat or has to break it up. Perhaps they are not aware that this is a chewable product which can be broken up into food if need be. Unless there is a non chewable they are using then I stand corrected.

Rated 5 out of 5 stars
By Mary on Nov 8, 2023

Love Chewy

Been using this on my 6 year old Lab mix for 18 months she won't take it willingly I have to put it in the back of her throat then she swallows it no problem she did the same with other meds she still scratches alot but I have never seen a flea so it must be something else I also get her food from Chewy which is great since I can't lift the bags of food and if I catch the delivery man he will set it inside my door. The only thing I didn't like since I needed Simpirica right away they started a new auto delivery and I didn't get the 5% discount If you have a rescue dog you should be sure they aren't allergic to the ingredients in the product

Rated 3 out of 5 stars
By Cee on Nov 5, 2023

Not excited

Figured I would go back to using Chewy hoping delivery would be better than it was before. This time my order was delayed because they needed to verify my purchase after I noticed an old card was on file and my auto purchase was trying to use it. I called in about it and was given misinformation. Couple days later I called again and was told they needed to go through all these steps to verify my payment, which now delays my delivery. All I got was sorry. I guess after this I’ll go back to my other process. This was not a smooth process, especially since I corrected the issue and the payment was processed that day.

Rated 1 out of 5 stars
By Jim on Nov 20, 2023

Chewy Pharmacy

The product I ordered is a great product but the Chewy Pharmacy is below average. There is no communication, they don't honor any refills the vet put on the original prescription, and finally, they are very slow at shipping the order. I could go on and on, but I think Chewy uses a third party vendor [vet] who is lacking in skills in dealing with Chewy customers.

Rated 1 out of 5 stars
By marybeth on Nov 8, 2023

Dangerous medication

I love chewy. Great company. This review is about Simparica Trio. My sweet 18 pound Cavapoo has been on this medication for 2 years. She experienced bloody diarrhea and vomiting bile a day or 2 after each dose. I took her to vet and GI specialist multiple times costing thousands. It finally occurred to me the episodes seemed to start 24-48 hours after taking this med. I stopped the med and the symptoms never occurred. again. Bad med for my pup.

Rated 5 out of 5 stars
By NANCY on Nov 23, 2023

Works well for us.

We have a seven year old German Shepherd and we have been using this product for a couple of years. We have not had a single problem. My biggest issue is which box to purchase. She is right at the cut off for the one ending at 88 lbs. so I am torn whether to buy this one every time or the one above this. I would truly appreciate any advice.

Rated 1 out of 5 stars
By Lisa on Nov 18, 2023

A real heartfelt review

One of my dogs choked to death this morning on this treatment. I can not fully blame the manufacturer of this product because my dog was excited about going to the kennel and did not chew the pill. She swallowed it. These pills are very hard, unlike rivals that are soft chewables. So she swallowed this rather than chew it. She immediately began choking, and I did everything I could to remove it. I tried sticking my fingers down as far as I could. Unfortunately by the time we got to a vet, she had died. She was a semi large, 89 pound mix dog that was only 2 years old. It is heart crushing to lose her, but especially in this horrible manner. So I can not recommend this product because of this. Ruby, we will always miss you and love you.