Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box)

By Simparica Trio
Rated 4.6154 out of 5 stars
Prescription Item
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Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 7
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Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply) slide 1 of 7

$170.73Chewy Price
$162.19Autoship Price
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This Item - Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)
Rated 4.6154 out of 5 stars
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About This Item

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 88.1 and 132 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here

About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.6154 out of 5 stars
78 Reviews
Would recommend to a friend

78 Customer Reviews

Rated 1 out of 5 stars
By karen on Sep 13, 2022

Sadly not successful

I had high hopes for this medication as both of my dogs are over 100 lbs. and the idea of having heart worm and flea/tick medication in one chewable that covered my dogs weight was very appealing. One dog ate it but not enthusiastically and I had to fight the other dog. It's a big, hard chew that was almost impossible to break into easy to hide pieces. I doubt I'll be able to get one and maybe both dogs to eat it next month. But to be clear, this isn't the fault of Chewy or the manufacturer. It's just not an irresistible treat.

Rated 2 out of 5 stars
By Sam4 on Aug 2, 2022

2/2 dogs tested positive for heartworm

At last years annual vet appt both dogs tested negative for heartworms. At that time my vet gave me a script for Simparica Trio which I was thrilled to begin as it covered fleas & ticks as well as other parasites. The dogs take their tablet every month no problem, another bonus for the product. Unfortunately at todays annual vet visit both dogs tested positive for heartworms. While I understand no preventative is 100% effective, I'm let down as I felt the top dollar price tag warranted top notch protection for my boys. I gave this product 2 stars because it has in fact protected against fleas & ticks.

Rated 5 out of 5 stars
By marialisa on Aug 19, 2022

Keepin' the buggies away

My boys have been on Simparica Trio for 4 years, and "so far - so good". I live in upstate NY, and we have had very good results keeping the fleas, ticks and worms at bay. That's all I can ask. Given in a treat form, no less!

Rated 5 out of 5 stars
By Boop on Sep 22, 2022

Simparico Trio ROCKS!

My dog any fleas. Great producttakes these pills with no problem. They work wonderfully. I may see a bit of flea dirt,but, never any fleas or ticks.

Rated 4 out of 5 stars
By Herme on Jul 13, 2022

Works great!

This product is wonderful. Preventing heartworms and intestinal worms as well as fleas and ticks. Everything in one. Only I issue I have is my pups won't eat it. I have to put it down their throats which isn't that easy because it is a large, hard pill. Other than that it's great.

Rated 5 out of 5 stars
By Deana on May 17, 2022

Heck yeah!

I’ve been on this for about 4 months now and not a tick or flea in sight. We are in Vermont where mom says the ticks are really bad. As you can see it’s spring right now; lush, green, and teeming with newly awakened ticks everywhere. Plus we like to go hiking in the woods where they dwell under the leaves. So far, this stuff is keeping all of those bad bugs away from me! I eat them right up too, though that’s not saying much since I eat just about anything! My tummy can be pretty sensitive, and a lot of things give me diarrhea. These don’t do that, so yay :-D Mom says it’s a little expensive up front, but works out pretty well in the end when you factor in it’s a six mo supply and only one medication instead of two. Plus they are running an amazing special right now for first time auto ship!

Rated 4 out of 5 stars
By Fatcat on Jul 9, 2022

Trial basis so far so good

Just started this for my 3 yr old Rottie seems to be working but only been on it for one dose. Will review again for 6 mo refill.

Rated 4 out of 5 stars
By AmandaRT on Aug 5, 2022

Good stuff

Female Cane Corso loves them. So far so good and hope that she continues to love it.

Rated 5 out of 5 stars
By Great on Sep 12, 2022

Love the service!

Works great for our pup. We have him on it year round.

Rated 5 out of 5 stars
By Skylar on Apr 8, 2022

Not an awful service.

It does make it easier to order online when the vet doesn’t have it. But I had issues trying to order which was not all chewys fault. I will continue to use the service honestly. Just frustrating when stuff has to be reordered and the. Takes awhile to show up.