Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), slide 1 of 1

Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box), 6 Chewable Tablets (6-mos. supply)

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Description

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 88.1 and 132 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Uses

Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Possible Side Effects

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications for the use of SIMPARICA TRIO.

Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here
  1. Prescribing Information

See all items by Simparica Trio

  • Item Number
    224909
  • For Use With
    Dogs
  • Generic Name
    sarolander, moxidectin, and pyrantel
  • Administration Form
    Oral
  • Common Brand Name(s)
    Simparica Trio
  • Usage
    Prevention, Treatment
  • Brand
    Zoetis
  • Lifestage
    Puppy, Adult
  • Breed Size
    Large Breeds, Giant Breeds
  • Product Form
    Chewable Tablet
  • Strength
    72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg Pyrantel
  • Health Condition
    Heartworms, Ticks, Fleas, Roundworms, Hookworms
  • Drug Type
    Parasiticide
Ingredients
Ingredients

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Instructions
Recommended Dosage

This medication should be administered orally at monthly intervals. Consult your veterinarian for proper dosing instructions.

Storage Instructions

Store at or below 30°C (86°F).

FAQ

What are the key benefits of Simparica Trio?

Comprehensive Protection with Potent Heartworm Coverage

  • Trio of Parasite Protection:
    • Heartworm disease
    • Ticks and fleas
    • Hookworms and roundworms

Convenience: One Monthly Product Does the Job of Two or More

  • Greater than 75% of pet owners aren't protecting dogs from all parasites Simparica Trio covers
  • Around 50% of pet owners protect against just ticks & fleas or heartworm

Tasty Chew for Puppies and Dogs

  • Demonstrated safety in dogs as young as 8 weeks of age
  • Highly palatable (91.9% of dogs voluntarily consumed)

What is the efficacy of Simparica Trio?

In clinical trials, Simparica Trio:

  • Was 100% effective against heartworm disease in dogs after one dose
  • Started killing fleas within 4 hours and achieved 100% efficacy 8 hours after treatment
  • Was >98.9 % effective against tick infestations in 48 hours
  • Resulted in 99.2% efficacy for adult roundworm and reduction in fecal egg count, and >94% efficacy for hookworm

What should I do if a dose is missed, or if my dog vomits after administration?

  • If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

Why should I recommend Simparica Trio or Simparica?

  • Simparica and Simparica Trio are both highly palatable chews that protect against ticks and fleas in dogs, but Simparica Trio also has the added benefit of moxidectin and pyrantel to protect dogs against heartworms disease, roundworms, and hookworms.

How do Simparica Trio’s active ingredients work?

  • Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
  • Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
  • Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

How old does my dog have to be to start using Simparica Trio?

  • Simparica Trio has been demonstrated safe for puppies as young as 8 weeks, and weighing as little as 2.8 lbs.

Are Simparica Trio tablets able to be split for administration?

  • Simparica Trio chewables are not scored and cannot be divided.

Is administering Simparica Trio at the same time as other heartworm, tick, or flea medications safe?

  • At this time, No studies have been conducted to evaluate Simparica Trio administered alongside with other medications. But, Simparica Trio has demonstrated efficacy against heartworm disease, ticks and fleas in one chewable so there is no need to administer another product.

Can Simparica Trio be administered to cats?

  • Simparica Trio has only been approved for dogs and cannot be administered to cats.

How does Simparica Trio differ from other preventatives?

  • Simparica Trio is a first of its kind monthly chewable to protect dogs against heartworm disease, fleas, five types of ticks, hookworms and roundworms.

How often should I give Simparica Trio to my dog?

  • Administer Simparica Trio chewable once a month to your dog.

How do I switch from a flea and tick medication or another heartworm medication?

  • To ensure your dog is kept protected through the process, talk to your veterinarian before switching to Simparica Trio from another preventive medication.

Does Simparica Trio require a prescription?

  • Simparica Trio does require a prescription. Talk to your vet today about Simparica Trio, and your veterinarian can prescribe the correct dose for your dog.

If I’m late giving a Simparica Trio dose, what should I do?

  • Give a new dose immediately if a dose is missed. A new dose should be given again if a dose is spit out. Then, continue on the monthly prescribed dosing schedule.

What are some signs and symptoms of heartworm disease in dogs?

  • The first signs of heartworm disease may be mild and hard to notice. As time progresses, you might see something known as heartworm cough, a decreased appetite, or a reluctance to exercise. More advanced stages of heartworm disease result in symptoms including trouble breathing, pale gums or dark urine—a result of blocked blood flow.

Is there a cure for heartworm disease?

  • Thankfully, heartworm disease can be treated, but the process can be pricey, lengthy and hard on your dog’s health. While heartworms can be removed, the damage to your dog’s heart and lungs may remain. Heartworm disease preventatives for dogs protect your dog from the effects of heartworm disease and prevent this trauma.

What should I do if my dog has already tested positive for heartworm disease?

  • If your veterinarian has confirmed this diagnosis, they will talk to you about how to treat heartworm disease in your dog.

How fast does Simparica Trio work to kill ticks and fleas?

  • Simparica Trio works fast to get rid of ticks and fleas on dogs. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

Are hookworms contagious?

  • Dogs become infected with hookworms from contact with contaminated feces, contaminated environments, from mother to pup, as well as eating wild animals. Hookworms in dog feces can lead to contaminated outdoor areas, which is how people can get hookworm infection.

What are intestinal parasite symptoms?

  • Both hookworms and roundworms can cause malnutrition in dogs, shown by anemia, weakness, weight loss or stunted growth.
  • Roundworms can also cause vomiting, diarrhea or a pot-bellied appearance.
  • Hookworms can cause pale gums and itchy paws. Hookworms can be deadly if left untreated, especially in young puppies or adult dogs with a weakened immune system.
Rating: 4.8 of 5 stars 14 Reviews 14 Reviews 4.9 out of 5 Stars

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Rating: 4.8 of 5 stars 4.9 / 5

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14 Reviews

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  • 5 out of 5 stars

    Less expensive than you’d think

    By LabMom on Jan 22, 2021

    I was originally hesitant to try Simparica Trio due to the initial sticker shock. We were previously using both Bravecto every 3 months and Sentinal monthly to do the job that’s covered by one monthly dose of Simparica Trio. When I did the math, I was surprised to see that treating my (2) 100 pound labs would be much easier and cost effective this way. I was a little worried that they wouldn’t eat the HUGE tablet, but they both scarfed it right down... not even sure if they chewed it lol!

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  • 5 out of 5 stars

    Great service

    By Chuck on Feb 5, 2021

    The team at Chewy's works hard to make sure everything is right. They worked with my Vet to get what I needed. I am very happy with their service. I would recommend them.

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  • 5 out of 5 stars

    Works well

    By Dgydaddy on Jan 21, 2021

    This product is simpler than seperate heartworm & flea treatments. For me, it has worked very well with no adverse effects.

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  • 5 out of 5 stars

    Very professional service

    By Inga on Jan 29, 2021

    Our service adviser was very helpful and professional handling our lost order

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  • 5 out of 5 stars

    Best site ever

    By hayleigh on Feb 9, 2021

    Was easy to order and got to me quickly. Love this site!

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  • 4 out of 5 stars

    Hard to get him to take those big pills, will not chew them

    By zeus on Jul 24, 2020

    I had to break them in half, and feed him chicken with butter on it , to make him take them , tried to shove the whole tablet , then tried the 1/2 tablet.. didn't work so we gave up and fed him again... hope they work this is the first pill,

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  • 4 out of 5 stars

    Simparica Trio Chewable

    By Onyx01 on Aug 5, 2020

    It’s nice to have an all in one chewable that the dogs really like. I know there are other all in ones but my dogs didn’t enjoy the taste. My only complaint is that it is way too expensive.

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  • 5 out of 5 stars

    Great product

    By MamaFer on Nov 6, 2020

    My Dane gobbled it right up and no side effects like other medications!

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  • 5 out of 5 stars

    Prompt complete service

    By Thomas on Nov 1, 2020

    Chewy confirmed script with my vet and promptly shipped the items.

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  • 5 out of 5 stars

    He Likes Them!

    By thesnowqueen on Jun 21, 2020

    This was my first order of the Simparica Trio. I was using Heart Guard and NextGuard, but Max was not liking the taste I guess, because I had a terrible time getting him to take them. He sniffed and nibbled at the Simparica, and then ate it willingly! And now I only have to give him one chew a month instead of two. It's a bit more expensive, but worth it since he eats it without a problem. Too soon yet to say how it works though.

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