Simparica Trio Chewable Tablet for Dogs, 88.1-132.0 lbs, (Brown Box)

By Simparica Trio
Rated 4.4895 out of 5 stars
Prescription Item

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About This Item


Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 88.1 and 132 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer. One count orders of manufacturer-sealed blister packs will arrive in a resealable plastic bag.

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Play Video: Learn More About Simparica Trio From Our Team of Experts
Learn More About Simparica Trio From Our Team of Experts

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About Simparica Trio for Dogs

Go With Simparica Trio

Give your dog triple protection with Simparica Trio. It's the first monthly chewable that provides defense against heartworm disease, fleas & ticks*, roundworms**, and hookworms***.

Triple Protection, Made Simple

Just one Simparica Trio dose does the job of two or three products, protecting against common parasites that can threaten the health of your dog. It is easy to give and can help simplify your routine as you protect your dog every month.

Use Simparica Trio for Puppies

When puppies are exposed to parasites, it can lead to serious health concerns. Make sure to protect your little ones from the start with Simparica Trio. It is demonstrated safe for puppies 8 weeks and older who weigh at least 2.8 pounds.

Enhance Your Dog’s Protection

Just 1 monthly Simparica Trio chewable provided 100% protection from heartworm disease in a study.


The only combination chewable proven to kill 5 types of ticks. Competitive chewable brands are only approved to kill 4.

Kills fleas before they can even lay eggs. Starts killing fleas within 4 hours, with 100% effectiveness achieved in 8 hours in a study.


Treats and controls roundworms and hookworms to protect dogs from intestinal parasites.


Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea. See full Prescribing Information.
Prescribing Information.

*Amblyomma americanum, Abylomma maculatum, Dermacentor variabilis, Ixodes scapularis, and Rhicephalus sanguineus. **Toxocara canis and Toxascaris leonina. ***Ancylostoma caninum and Uncinaria stenocephala.

All trademarks are the property of Zoetis Services LLC or a related company or a licensor unless otherwise noted. © 2021 Zoetis Services LLC. All rights reserved. STR-00337

About Simparica Trio

Simparica Trio is a once-a-month, easy-to-give chewable that helps simplify protecting your pet every month. With three active ingredients designed for defense, Simparica Trio keeps dogs protected from heartworm disease, fleas & ticks, and roundworms & hookworms. Dogs get all this protection with just one dose of Simparica Trio. Available by prescription only.
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ReviewsWrite a Review

Rated 4.4895 out of 5 stars
190 Ratings
Would recommend to a friend

159 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Jose on Nov 10, 2023

Lulu from DC

Lulu, my 90-pound lovely old English Sheepdog, ate the Simparica Trio tablet with gusto. And once a month she gets the treat without any sideffects. Chewy provided a coupon to make its 6-tablet cost less offensive. But it still is a heavy expense for six pills.

Rated 1 out of 5 stars
By Sophia on Nov 4, 2023

Package never came home

I reached out trying to change our address prior to the meds being shipped but unfortunately this order was still shipped at our old address where I no longer reside. 180$ worth of meds went to waste. Is there anything that can be done to fix this?

Rated 1 out of 5 stars
By Linzie on Nov 6, 2023

do not buy

Made my dog ridiculously sick she was throwing up everything including water for a week straight and had terrible diarrhea ended up in the emergency vet. Please don’t give this to your pets it can also cause tremors and seizures.

Rated 5 out of 5 stars
By Pamela on Oct 29, 2023

Covers dog health

I had my dog on 2 different meds to cover flea & tick and worms. When looking at Simparica, yes, it’s costly, but Chewy had the best price. My dog has never experienced a bug or intestinal worm. He gladly chews the huge pill and I know he’s protected.

Rated 5 out of 5 stars
By Liz on Nov 16, 2023

Chewy made getting this prescription a breeze! Our Bernese Mountain Dog has been on this and despite living in a very tick heavy location, we have not had a single issue so far!

Rated 3 out of 5 stars
By Jessica on Sep 18, 2023

flea eggs

Have been using this product for awhile on my 12 year golden I noticed she had started getting raw dots all over her skin then I noticed the flea eggs which st first I thought were scabs from raw places but I just bathed her and I can not get them off of her I guess product killed the fleas but I didn’t know she would end up with the egg infestation What can I do and for raw patches too?

Rated 5 out of 5 stars
By Lauren on Nov 1, 2023

Fast and Easy Service

Chewy made the transaction very easy. They reached out to my vet to confirm the prescription within 24hrs of placing the order. Delivery was very fast and I even received a coupon for next purchase.

Rated 5 out of 5 stars
By Joan on Nov 8, 2023

Simparica Trio

One Convenient pill to take care of fleas, ticks and heartworm. Wish it was more chewy since I have to break it down for my dog to be able to take such a large pill.

Rated 5 out of 5 stars
By Diana on Nov 5, 2023

Flea med

Ellie has been on this medication for a few years. She has NEVER had a flea or tick while on this. She thinks it's a treat and I have no difficulty giving it to her.

Rated 5 out of 5 stars
By Nina on Nov 18, 2023

Good prevention

Great to give one product to protect against fleas, ticks, and heartworm. Only downside is it must be given monthly but box has 6 month dose.