Simparica Trio Chewable Tablets for Dogs, 22.1-44.0 lb (Teal Box), slide 1 of 1
Deal

Simparica Trio Chewable Tablets for Dogs, 22.1-44.0 lb, 6 treatments (Teal Box)

Prescription Item

  • Price:

    $145.47 FREE Shipping on this item

Autoship: &Save

$138.20(Save an extra 5%)

Simply select Autoship at checkout for easy regular deliveries.


In stock

This item requires prescription approval. Details

Medications ship separately. Delivery times may vary. Details

We'll collect your pet's prescription information at Checkout.

cw-icon-heart Created with Sketch. Add to Favorites
Description

Help your furry friend fight off pests with Simparica Trio Chewable Tablets for Dogs! Every purchase comes with 6 treatments that are specially formulated for canine companions 8 weeks of age and older, weighing between 22.1 and 44 pounds. Simparica Trio is the first and only product that combines sarolaner, moxidectin and pyrantel in each treatment to help prevent heartworm disease, kill fleas before they can lay eggs, kill 5 types of ticks, treat and prevent flea infestations and treat and control roundworms and hookworms. And each monthly chewable tablet has a palatable liver flavor and can be taken with or without food!

Uses

Monthly Simparica Trio prevents heartworm disease, kills adult fleas and is indicated for the treatment and prevention of flea infestations, the treatment and control of tick infestations, and the treatment and control of roundworm and adult hookworm infections in dogs and puppies 8 weeks of age and older, and weighing 2.8 pounds or greater.

Possible Side Effects

The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Drug & Food Interactions

There are no known contraindications for the use of SIMPARICA TRIO.

Precautions

Not for use in humans. Keep this and all drugs out of reach of children. Use with caution in dogs with a history of seizures. Simparica Trio contains sarolaner, a member of the isoxazoline class, which has been associated with neurologic adverse reactions including tremors, ataxia, and seizures in dogs with or without a history of neurologic disorders. The safe use of Simparica Trio has not been evaluated in breeding, pregnant, or lactating dogs. The most frequently reported adverse reactions in clinical trials were vomiting and diarrhea.

Dosage Chart

Color on BoxWeight RangeStrengthDosageProduct Page
Gold2.8-5.5 lbs3 mg Sarolaner, 0.06 mg Moxidectin, 12.5 mg PyrantelAdminister orally once a month✓-Click Here
Purple5.6-11.0 lbs6 mg Sarolaner, 0.12 mg Moxidectin, 25 mg PyrantelAdminister orally once a month✓-Click Here
Caramel11.1-22.0 lbs12 mg Sarolaner, 0.24 mg Moxidectin, 50 mg PyrantelAdminister orally once a month✓-Click Here
Teal22.1-44.0 lbs24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg PyrantelAdminister orally once a month✓-Click Here
Green44.1-88.0 lbs48 mg Sarolaner, 0.96 mg Moxidectin, 200 mg PyrantelAdminister orally once a month✓-Click Here
Brown88.1-132.0 lbs72 mg Sarolaner, 1.44 mg Moxidectin, 300 mg PyrantelAdminister orally once a month✓-Click Here
  1. Prescribing Information

See all items by Simparica Trio

  • Item Number
    224821
  • For Use With
    Dogs
  • Generic Name
    sarolander, moxidectin, and pyrantel
  • Administration Form
    Oral
  • Brand
    Zoetis
  • Lifestage
    Adult, Puppy
  • Breed Size
    Extra Small & Toy Breeds
  • Product Form
    Chewable Tablet
  • Strength
    24 mg Sarolaner, 0.48 mg Moxidectin, 100 mg Pyrantel
  • Health Condition
    Heartworms, Ticks, Fleas, Roundworms, Hookworms
  • Drug Type
    Parasiticide
Ingredients
Ingredients

sarolaner, moxidectin, and pyrantel (as pamoate salt).

Instructions
Recommended Dosage

This medication should be administered orally at monthly intervals. Consult your veterinarian for proper dosing instructions.

Storage Instructions

Store at or below 30°C (86°F).

FAQ

What are the key benefits of Simparica Trio?

Comprehensive Protection with Potent Heartworm Coverage

  • Trio of Parasite Protection:
    • Heartworm disease
    • Ticks and fleas
    • Hookworms and roundworms

Convenience: One Monthly Product Does the Job of Two or More

  • Greater than 75% of pet owners aren't protecting dogs from all parasites Simparica Trio covers
  • Around 50% of pet owners protect against just ticks & fleas or heartworm

Tasty Chew for Puppies and Dogs

  • Demonstrated safety in dogs as young as 8 weeks of age
  • Highly palatable (91.9% of dogs voluntarily consumed)

What is the efficacy of Simparica Trio?

In clinical trials, Simparica Trio:

  • Was 100% effective against heartworm disease in dogs after one dose
  • Started killing fleas within 4 hours and achieved 100% efficacy 8 hours after treatment
  • Was >98.9 % effective against tick infestations in 48 hours
  • Resulted in 99.2% efficacy for adult roundworm and reduction in fecal egg count, and >94% efficacy for hookworm

What should I do if a dose is missed, or if my dog vomits after administration?

  • If a dose is missed, a new dose should be given immediately. If a dose is vomited or spit out, a new dose should be given again. Then, continue on the prescribed monthly dosing schedule.

Why should I recommend Simparica Trio or Simparica?

  • Simparica and Simparica Trio are both highly palatable chews that protect against ticks and fleas in dogs, but Simparica Trio also has the added benefit of moxidectin and pyrantel to protect dogs against heartworms disease, roundworms, and hookworms.

How do Simparica Trio’s active ingredients work?

  • Sarolaner is an acaricide and insecticide belonging to the isoxazoline group. Sarolaner inhibits the function of the neurotransmitter gamma aminobutyric acid (GABA) receptor and glutamate receptor and works at the neuromuscular junction in insects. This results in uncontrolled neuromuscular activity leading to death in insects or acarines.
  • Moxidectin is an endectocide in the macrocyclic lactone class. Moxidectin acts by interfering with the chloride channel-mediated neurotransmission in the parasite. This results in paralysis and death of the parasite.
  • Pyrantel pamoate is a nematocide belonging to the tetrahydropyrimidine class. Pyrantel acts as a depolarizing, neuromuscular-blocking agent in susceptible parasites, which causes paralysis and death or expulsion of the organism.

How old does my dog have to be to start using Simparica Trio?

  • Simparica Trio has been demonstrated safe for puppies as young as 8 weeks, and weighing as little as 2.8 lbs.

Are Simparica Trio tablets able to be split for administration?

  • Simparica Trio chewables are not scored and cannot be divided.

Is administering Simparica Trio at the same time as other heartworm, tick, or flea medications safe?

  • At this time, No studies have been conducted to evaluate Simparica Trio administered alongside with other medications. But, Simparica Trio has demonstrated efficacy against heartworm disease, ticks and fleas in one chewable so there is no need to administer another product.

Can Simparica Trio be administered to cats?

  • Simparica Trio has only been approved for dogs and cannot be administered to cats.

How does Simparica Trio differ from other preventatives?

  • Simparica Trio is a first of its kind monthly chewable to protect dogs against heartworm disease, fleas, five types of ticks, hookworms and roundworms.

How often should I give Simparica Trio to my dog?

  • Administer Simparica Trio chewable once a month to your dog.

How do I switch from a flea and tick medication or another heartworm medication?

  • To ensure your dog is kept protected through the process, talk to your veterinarian before switching to Simparica Trio from another preventive medication.

Does Simparica Trio require a prescription?

  • Simparica Trio does require a prescription. Talk to your vet today about Simparica Trio, and your veterinarian can prescribe the correct dose for your dog.

If I’m late giving a Simparica Trio dose, what should I do?

  • Give a new dose immediately if a dose is missed. A new dose should be given again if a dose is spit out. Then, continue on the monthly prescribed dosing schedule.

What are some signs and symptoms of heartworm disease in dogs?

  • The first signs of heartworm disease may be mild and hard to notice. As time progresses, you might see something known as heartworm cough, a decreased appetite, or a reluctance to exercise. More advanced stages of heartworm disease result in symptoms including trouble breathing, pale gums or dark urine—a result of blocked blood flow.

Is there a cure for heartworm disease?

  • Thankfully, heartworm disease can be treated, but the process can be pricey, lengthy and hard on your dog’s health. While heartworms can be removed, the damage to your dog’s heart and lungs may remain. Heartworm disease preventatives for dogs protect your dog from the effects of heartworm disease and prevent this trauma.

What should I do if my dog has already tested positive for heartworm disease?

  • If your veterinarian has confirmed this diagnosis, they will talk to you about how to treat heartworm disease in your dog.

How fast does Simparica Trio work to kill ticks and fleas?

  • Simparica Trio works fast to get rid of ticks and fleas on dogs. It starts to kill deer ticks within 8 hours, and fleas within 4 hours.

Are hookworms contagious?

  • Dogs become infected with hookworms from contact with contaminated feces, contaminated environments, from mother to pup, as well as eating wild animals. Hookworms in dog feces can lead to contaminated outdoor areas, which is how people can get hookworm infection.

What are intestinal parasite symptoms?

  • Both hookworms and roundworms can cause malnutrition in dogs, shown by anemia, weakness, weight loss or stunted growth.
  • Roundworms can also cause vomiting, diarrhea or a pot-bellied appearance.
  • Hookworms can cause pale gums and itchy paws. Hookworms can be deadly if left untreated, especially in young puppies or adult dogs with a weakened immune system.
Rating: 4.3 of 5 stars 16 Reviews 16 Reviews 4.3 out of 5 Stars

Filter reviews by star rating

88% Recommend

88% of reviewersrecommend this product

Rating: 4.3 of 5 stars 4.3 / 5

You've Already Reviewed This Item

16 Reviews

Showing 1-10 of 16 Reviews

  • 1 out of 5 stars

    Doesn’t kill fleas

    By on

    My dog has been on this for the past 6 months. Beginning this week, we have a complete house-wide flea infestation. Use this medication only if you’re dying to pay $400 to the pest control man and spend days scratching at your ankles and laundering everything in hot water.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Review is about delivery

    By on

    My pup took her first Simparica Trio tablet only a week ago, so I cannot accurately review this medication at this early date - though I can testify it did not make her sick. My 5 star rating is for Chewy's prompt handling of my order. This is the first time I've ordered a prescription from Chewy and I was very impressed with their prompt handling of my order. I received the medication 4 days after I placed the order. Fast, considering they had to call my vet, etc. I'm always impressed with the quick turn-around time of my Chewy orders.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Chewy Delivery

    By on

    This is the first time we’re using Simparica. It’s too soon to provide a review. However, I have been Ordering through Chewy for a couple of years. The experience has been exceptional. In the rare occasions that I needed to call customer service, there was no wait time and their reps are friendly, knowledgeable and eager to assist. I highly recommend Chewy.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    No cheese needed!!

    By on

    Covers worms, ticks, & fleas! Super easy, way better than the messy drops that are applied topically.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Tasty Simparica

    By on

    I'd compare them to a tasty Merlot, or maybe a nice Chianti, or as I think of it further, probably Cabernet!

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Only one!!

    By on

    This flea, tick, and heartworm medication is loved by my dog and by me! Chewable! Only one! And only once a month for all three preventives! Not only time-saving, but also less expensive than buying separate meds.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Great product

    By on

    Came so fast and is great. Got auto ship so I literally never have to worry - so so pleased!

    You liked it! Something went wrong. Please try again later. Report
  • 3 out of 5 stars

    Pharmacy did a good job

    By on

    Pharmacy did a good job. Shipping gave me 4 delivery dates, then delivered on another date...

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    So far so good, tiny and easy to give

    By on

    This is our first dog and we tried first the Heartgard and Nextgard. This one is smaller and less "chewy". He had a little bit of diarrhea the first two days but went away after that. He took it easily and did not seem to not like the flavor. So far so good.

    You liked it! Something went wrong. Please try again later. Report
  • 4 out of 5 stars

    Chewy Pharmacy needs great improvement

    By on

    Like the ease of having a heartworm and flea/tick medicine all in one pill. Just way to long to get from Chewy's pharmacy.

    You liked it! Something went wrong. Please try again later. Report