Simplicef (Cefpodoxime Proxetil) Tablets for Dogs, slide 1 of 1

Simplicef (Cefpodoxime Proxetil) Tablets for Dogs

Prescription Item

  • Price:

    $1.93 FREE Shipping over $49

Autoship: &Save

$1.83(Save an extra 5%)

Simply select Autoship at checkout for easy regular deliveries.

In stock
Strength: 100-mg
  • Click to select 200-mg In stock
Count: 1 tablet

This item requires prescription approval. Details

Medications ship separately. Delivery times may vary. Details

We'll collect your pet's prescription information at Checkout.

cw-icon-heart Created with Sketch. Add to Favorites

Simplicef tablets are prescribed by veterinarians for the treatment of various infections in dogs caused by gram-positive and gram-negative bacteria. Some of these infections include but are not limited to skin, urinary tract, bone, and respiratory tract infections. Best of all, this antimicrobial comes in a tablet form, so you can feed it by mouth.


Simplicef tablets are indicated for the treatment of skin infections, wounds and abscesses in dogs caused by specific strains of bacteria.

Possible Side Effects

Side effects may include vomiting, diarrhea, increased water-intake and decreased appetite.

Drug & Food Interactions

Discuss medications and supplements your pet is taking with your vet as interactions are possible with Simplicef. Aminoglycosides (gentamicin, neomycin), amphotericin B, anticoagulants (blood thinners, such as heparin or warfarin), and probenicid may interact with Simplicef. Other interactions may occur.


If your pet is allergic to cephalosporins or penicillins, do not give Simplicef. Simplicef should not be given to pregnant or lactating animals because it passes through the milk. Pets with seizure disorders, epilepsy, or kidney disease should be given Simplicef cautiously and only as directed. Simplicef may cause a false-positive glucose test result with certain brands of urine test strips.

  1. Prescribing Information

See all items by Simplicef

  • Item Number
  • Common Brand Name(s)
    Simplicef, Vantin
  • Generic Name
    Cefpodoxime Proxetil
  • For Use With
  • Administration Form
  • Brand
  • Product Form
  • Health Condition
    Skin Infections, Wounds, Urinary Tract Infections (UTI)
  • Drug Type

Cefpodoxime Proxetil.

Recommended Dosage

The dose range of Simplicef (cefpodoxime proxetil) tablets is 5-10 mg/kg (2.3-4.5 mg/lb) body weight, administered orally, once a day. The dose may be given with or without food. The determination of dosage for any particular pet must take into consideration the severity and nature of the infection, the susceptibility of the causative organisms, and the integrity of the pet's host-defense mechanisms.

Storage Instructions

Store tablets at controlled room temperatures of 68° - 77°F. Replace cap securely after each opening.


What is Simplicef?

This is a cephalosporin antibiotic that works to treat skin, urinary tract, bone, and respiratory tract infections plus other susceptible infections.

What are the benefits of Simplicef?

  • Works against gram-positive and gram-negative bacteria.
  • Only requires once a day administration.
  • Can be given by mouth at home.

How is this medication given?

Simplicef is usually given once a day but always follow your veterinarians instruction. Try to give with food.

Complete all medication or symptoms may return or worsen.

Only use this medication for the pet it has been prescribed for. Contact your veterinarian if you are unsure of how to give Simplicef correctly.

How does this medication work?

Simplicef works by stopping the bacteriascell wall production which will result in the death of susceptible gram-positive and gram-negative organisms.

What results can I expect?

Simplicef circulates through the body once it is absorbed through the intestinal tract. The blood stream then carries the medication to various organs in the body that are infected. All medication must be completed even though your pet might feel better sooner or symptoms can return or worsen.

Rating: 4.8 of 5 stars 6 Reviews 6 Reviews 4.8 out of 5 Stars

Filter reviews by star rating

100% Recommend

100% of reviewersrecommend this product

Rating: 4.8 of 5 stars 4.8 / 5

You've Already Reviewed This Item

6 Reviews

Showing 6 Reviews

  • 5 out of 5 stars

    Great Medicine

    By Sammi on Mar 22, 2020

    This works great for my girl and happy I can order it from Chewy

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Excellent Product

    By Sarah on Oct 21, 2019

    My dog has and will be on Simplicel for a long time for a chronic illness. He has tolerated it well. Price is cheaper than other medicines.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Excellent Product & Price Point

    By ChiTownLady on Jul 23, 2019

    The product is an antibiotic. It was used for a bad skin infection for our dog, Annie. The price point is excellent. My Vet recommended the medication. The product worked quickly and effectively. Wow, I saw an improvement in Annie's skin infection in 48 hours. I received the medication within 2 days. I did not order it by FedEx. The reason I ordered the medication from is because I saved over $18 -- who doesn't want to save money!

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Great for problematic UTI's in dogs

    By Walter on Mar 9, 2019

    This medication appears to work well for our dog, who tends to get UTI's pn a regular basis. There have been no side affects to date

    You liked it! Something went wrong. Please try again later. Report
  • 4 out of 5 stars

    Very satisfied

    By Luzee29 on May 24, 2019

    Got prescription from the vet and delivery was fast.

    You liked it! Something went wrong. Please try again later. Report
  • 5 out of 5 stars

    Diego urinary meds

    By Bowezx on Nov 25, 2018

    Our 15 year old Shelty is doing well on these meds

    You liked it! Something went wrong. Please try again later. Report