Trifexis Chewable Tablet for Dogs, 40.1-60 lbs, (Blue Box), 6 Chewable Tablets (6-mos. supply)
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Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
UsesTrifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
Possible Side EffectsWhen used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
Drug & Food InteractionsAlways communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
Precautions
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing
heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Dosage Chart
| Color on Box | Weight Range | Strength | Dosage | Product Page |
|---|---|---|---|---|
| Magenta | 5-10 lbs | 140 mg Spinosad & 2.3 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Orange | 10.1-20 lbs | 270 mg Spinosad & 4.5 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Green | 20.1-40 lbs | 560 mg Spinosad & 9.3 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Blue | 40.1-60 lbs | 810 mg Spinosad & 13.5 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Brown | 60.1-120 lbs | 1620 mg Spinosad & 27 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
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Item Number146171
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Common Brand Name(s)Trifexis, Comfortis
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For Use WithDogs
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Generic NameSpinosad, Milbemycin Oxime
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Administration FormOral
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BrandElanco
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Breed SizeMedium Breeds, Large Breeds
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Product FormChewable Tablet
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Strength810 mg Spinosad and 13.5 mg Milbemycin Oxime
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Health ConditionHeartworms, Fleas, Hookworms, Roundworms, Whipworms
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Drug TypeParasiticide
810 mg Spinosad and 13.5 mg Milbemycin Oxime.
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
Storage InstructionsStore at controlled room temperatures between 68° - 77°F.
What Is Trifexis (Spinosad + Milbemycin Oxime), And What Does It Protect Against?
Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.
What Are Some Of The Benefits Of Trifexis?
- Trifexis is an oral monthly product that rapidly kills fleas on dogs and is effective in preventing heartworm disease and treatment and control of adult hookworm (A. caninum), adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight and greater.
- Trifexis is approved by the FDA as safe and effective when used according to the label.
- Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study.
- Trifexis continues to kill fleas for a full month after treatment.
- Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
- Trifexis is available in five strengths. Each tablet is formulated to provide a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime according to body weight.
How Well Does Trifexis Work?
- In a well-controlled laboratory study, Trifexis was 100% effective against induced heartworm infections in dogs when administered for three consecutive monthly doses.
- In well-controlled laboratory studies, a single dose of Trifexis at labeled dose was effective in removing roundworms, whipworms and hookworms (A. caninum).
- In a well-controlled laboratory study, spinosad alone began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours.
- Spinosad kills fleas on dogs before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0 to 99.8% were observed during the course of three monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
What Are The Active Ingredients In Trifexis Chewable Tablets?
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
What Is The Flavoring In Trifexis Tablets?
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.
What Is The Flavoring In Trifexis Tablets?
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1
Is Trifexis Fda Approved?
Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.
Is It Safe To Give My Breeding Dogs Trifexis?
Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.
What Side Effects Might Occur With Trifexis?
As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
What Is The Most Common Adverse Event With Trifexis?
The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.
How Quickly Will Trifexis Kill Fleas?
In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.
Will Trifexis Kill Heartworms?
Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Which Heartworm Lifecycle Stage Does Trifexis Control?
Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.
Does Trifexis Protect Against Ticks?
No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.
My Dog Has Tapeworms. Will Trifexis Get Rid Of Those?
No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
About Trifexis
Powerful Protection
Trifexis gives your dog broad spectrum protection against five common canine parasites: fleas, heartworm disease, hookworms, roundworms, and whipworms. Just one tablet provides protection that you can rely on all month long.
Neutralize Threats
Trifexis works 24/7 to kill fleas and prevent reinfestation, but the protection doesn’t stop there. It also works to prevent heartworm disease and to treat and control adult hookworm, roundworm and whipworm infections to keep your dog protected. Why settle for anything less?
Flea Treatment and Prevention
Trifexis starts killing fleas in as little as 30 minutes, completely eliminating all adult fleas within 4 hours. And it keeps on killing fleas all month, eradicating newcomers before they can ever lay eggs and cause a new infestation.
Beef-Flavored Tablet
All this powerful coverage comes in a compact and easy-to-administer beef-flavored tablet. Trifexis can be given directly by hand, placed in your dog's food bowl, or hidden in a yummy treat. Administer with food for maximum effectiveness.
Dosed By Weight
Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!
Product Guide
Trifexis offers protection for dogs in most sizes and weights. Choose the option best suited for your furry friend
5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Indication
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
Important Safety Information
The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
About Trifexis
Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
Customer Reviews
93% Recommend
93% of reviewersrecommend this product
You've Already Reviewed This Item
156 Reviews
Showing 1-10 of 156 Reviews
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Worked - but my dog was really drowsy!
By Dani on Jan 21, 2021
First of all - this pill is HUGE! I tried hiding it in a pile of shredded cheese which is usually a fool proof method for giving medications to my 45lb goldendoodle, but she knew something was suspicious. Finally we were able to get her to swallow it after carefully wrapping it inside an envelope of American cheese. I was concerned when I noticed how drowsy she was a few hours later. She didn’t have any other side effects (like vomiting, etc.), she was just really sleepy for a few hours. Overall, it did its job killing off the fleas and I like that it covers her for heart worm and other parasites. I wish I was effective against ticks, though. Next time I will try to make sure she eats more food First of all - this pill is HUGE! I tried hiding it in a pile of shredded cheese which is usually a fool proof method for giving medications to my 45lb goldendoodle, but she knew something was suspicious. Finally we were able to get her to swallow it after carefully wrapping it inside an envelope of American cheese. I was concerned when I noticed how drowsy she was a few hours later. She didn’t have any other side effects (like vomiting, etc.), she was just really sleepy for a few hours. Overall, it did its job killing off the fleas and I like that it covers her for heart worm and other parasites. I wish I was effective against ticks, though. Next time I will try to make sure she eats more food before taking it to see if that helps with the drowsiness. … more
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Great product, fast delivery
By CNH82 on Jan 14, 2021
We’ve used Trifexis since our almost 8 year old dog was just a pup. It does what we need it to do! That’s why we continue to use it. As far as ordering from Chewy, I was a little nervous after reading reviews about getting prescriptions approved and what not but it only took 2 days (one of those days was New Years) to get an email saying the prescription was approved by our vet! From order to deliver it was about a week (with a holiday in there). I was pretty impressed to say the least. Needless to say we will be using Trifexis and Chewy for the foreseeable future!
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Doesn't protect from ticks
By lilly on Mar 1, 2021
For a broad-spectrum flea preventative it should protect against ticks and it doesn't. Im still finding fleas on my dog so I won't be purchasing this again. It's nice for the heart guard but Samparica trio does it all and im going to try that next.
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my vet warned me
By Lauren on Jan 15, 2021
I have been a longtime fan of chewy because I travel a lot and it makes my life easier. BUT My vet warned me not to buy flea meds from chewy because many people have told them they don’t work and I regret that I did not listen to them-paid over 100$ for 6 months of pills that have not worked AT ALL. My dog still has fleas all the time and it makes me worry she is not protected from heartworm as well. Heading to the vet to spend even more money getting the legit medication for my baby.
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Not the biggest fan
By Amunday on Feb 19, 2021
I didn't realize until after I purchased it that its not for ticks. Now I have to separately buy something for then I could hardly get my dog to eat it because it smells like medicine unkike the nexguard.
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How to give to dogs with ease
By Beware on Jan 22, 2021
I had to post this after reading all of the reviews stating their dogs hated taking this pill. I crushed the pill up and put it in some meaty gravy. All 3 of my dogs gobbled it up! I truly hope this helps some other pet owners.
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communication problem
By rose on Jan 1, 2021
there was a communication problem between chewy & the vet. Both saying they hadn't heard from the other. It took a week to get it straightened out, chewy cancelled my original order and I had to reorder.
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Disappointed in Delivery Time
By TREATS on Oct 9, 2020
I didn't realize and ran out of these for my Buddy. When I called and ordered these I called my Vet and explained we were ordering from Chewy because of Pandemic (Husband has Alzheimer's and Cancer) and would they process papers ASAP and they assured me as soon as they received them they would process them. I called Chewy back, placed the order, explained the urgency and felt as if everything was fine. I agree I should have stayed on top of it but my husband became very ill and the day I realized I hadn't received them I called and essentially nothing had been done. The person admitted the form had not been sent to the vet. When I called my vet she said she had the form and was filling it I didn't realize and ran out of these for my Buddy. When I called and ordered these I called my Vet and explained we were ordering from Chewy because of Pandemic (Husband has Alzheimer's and Cancer) and would they process papers ASAP and they assured me as soon as they received them they would process them. I called Chewy back, placed the order, explained the urgency and felt as if everything was fine. I agree I should have stayed on top of it but my husband became very ill and the day I realized I hadn't received them I called and essentially nothing had been done. The person admitted the form had not been sent to the vet. When I called my vet she said she had the form and was filling it out. My biggest problem with all of it...because mistakes happen.....but I asked that it be overnighted and you refused. … more
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Quick and Easy
By Heartworm on Jan 16, 2021
Quick and easy way to get you pet’s medications! No running out to the vet! Chewy handled it all including getting the prescription.
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Great Product for Great Price!
By kjcarter68 on Nov 2, 2020
Always a great experience with Chewy! It is nice that that the product can be purchased online and approved by your vet and then shipped right to your home. Best product for flea-tick for dogs.
