Trifexis Chewable Tablet for Dogs, 40.1-60 lbs, (Blue Box)

By Trifexis
Rated 4.3878 out of 5 stars
Prescription Item

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$139.04Chewy Price
$132.09Autoship Price
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Usually arrives in 3-5 days
We'll collect your pet's prescription information at Checkout.

This item requires prescription approval.

Medications ship separately. Delivery times may vary.

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About This Item


Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
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ReviewsWrite a Review

Rated 4.3878 out of 5 stars
214 Ratings
Would recommend to a friend

214 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 1 out of 5 stars
By Redneckbelle1972 on Jul 26, 2023


BUYER BEWARE!!!! Do not spend all this money on something that doesn't work. My dog still has fleas. I have to rinse her every other day. Can't use another flea prevention. In a hot mess now because this product is a three in one. Now I will be continuing the fight against fleas for 5 more months.

Rated 5 out of 5 stars
By Nancy on Apr 25, 2023

Pet Medication Return

I noticed the flea and tick medication was only that; no hear worm component. I had already given 1 of the 6 month supply when I noticed. I called and spoke to a vet who gladly agreed I could send the unused amount back and was sent what was needed. I received a FedEx label right away and am dropping it off today. That is great customer service.

Rated 4 out of 5 stars
By Elyse on Apr 22, 2023

Trifexis 1st Time

I had to change my Aussie Shepherd's flea repellant. This was the most compatible with her breed and similar to the Comfortis (now discontinued) she'd beeb on for 9 years. She is just in her first month's dose, is tolerating it well, and now has heartworm protection. So far so good. It is pricey, so here's hoping the old adage, "You get what you pay for." is true.

Rated 5 out of 5 stars
By Chuck on Jul 11, 2023

Superior Service

Chewy provides great products at great prices. Delivery is super fast. Customer service is 5 of 5.

Rated 5 out of 5 stars
By Umpy on Apr 28, 2023

Write a Review

Excellent service in ordering and delivery. The only thing that was disturbing is that there was not a treat for my well deserving dog, Lizee that absolutely loves getting boxes in the mail.

Rated 5 out of 5 stars
By Trifexis on Feb 26, 2023

Ez Pz To Give

My dog has really bad allergies, and since this medicine is recommended I give it to her so the fleas/etc. wont bother her during the year. Now, I dont shove the pill down her throat, I crush it up with something while its still in the pack until its more of a powder. Afterwards I mix it into some wet/dry food mix until she eats it all and its done!

Rated 5 out of 5 stars
By Wise1 on May 17, 2023

Good medication.

I have used this medication for 2 dogs. It work very well and the price is better than what a Vet charges.

Rated 5 out of 5 stars
By DaveK on Jul 15, 2023

good Meds

This stuff works. No side effects seen

Rated 4 out of 5 stars
By FrankieCheese on Nov 5, 2022

Works but at a cost

My pup is heartworm. flea and intestinal worm free thanks to Trifexis, HOWEVER getting him to take these huge tabs every month is a challenge. They don't smell, look or apparently taste appealing to him. I have to crush them and add them to his food. Although they state that vomiting after the first dose is common, he seems to repeat this every month. The only advanage gained is that it takes him over an hour now to toss his cookies. What this means is that I do not have to readminister his dose. These are not inexpensive at 6 month supply and having to readminister full doses every month has reduced 6 months to a 3 month supply. In conclusion, the medication is effective and works, but getting it in and down and keeping is down has been our challenge.

Rated 5 out of 5 stars
By Sandy on Mar 24, 2023

Easy Peasy

chewy is so convenient. Once your vet approves, you will get the product in no time.