Trifexis Chewable Tablet for Dogs, 40.1-60 lbs, (Blue Box), 6 Chewable Tablets (6-mos. supply)
Prescription Item
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Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
UsesTrifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
Possible Side EffectsWhen used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
Drug & Food InteractionsAlways communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
Precautions
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing
heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Dosage Chart
| Color on Box | Weight Range | Strength | Dosage | Product Page |
|---|---|---|---|---|
| Magenta | 5-10 lbs | 140 mg Spinosad & 2.3 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Orange | 10.1-20 lbs | 270 mg Spinosad & 4.5 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Green | 20.1-40 lbs | 560 mg Spinosad & 9.3 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Blue | 40.1-60 lbs | 810 mg Spinosad & 13.5 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
| Brown | 60.1-120 lbs | 1620 mg Spinosad & 27 mg Milbemycin Oxime | Administer orally once a month | ✓-Click Here |
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Item Number146171
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Common Brand Name(s)Trifexis, Comfortis
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For Use WithDogs
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Generic NameSpinosad, Milbemycin Oxime
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Administration FormOral
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Breed SizeMedium Breeds, Large Breeds
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Product FormChewable Tablet
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Strength810 mg Spinosad and 13.5 mg Milbemycin Oxime
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Health ConditionHeartworms, Fleas, Hookworms, Roundworms, Whipworms
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Drug TypeParasiticide
810 mg Spinosad and 13.5 mg Milbemycin Oxime.
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
Storage InstructionsStore at controlled room temperatures between 68° - 77°F.
What Is Trifexis (Spinosad + Milbemycin Oxime), And What Does It Protect Against?
Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.
What Are Some Of The Benefits Of Trifexis?
- Trifexis is an oral monthly product that rapidly kills fleas on dogs and is effective in preventing heartworm disease and treatment and control of adult hookworm (A. caninum), adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight and greater.
- Trifexis is approved by the FDA as safe and effective when used according to the label.
- Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study.
- Trifexis continues to kill fleas for a full month after treatment.
- Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
- Trifexis is available in five strengths. Each tablet is formulated to provide a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime according to body weight.
How Well Does Trifexis Work?
- In a well-controlled laboratory study, Trifexis was 100% effective against induced heartworm infections in dogs when administered for three consecutive monthly doses.
- In well-controlled laboratory studies, a single dose of Trifexis at labeled dose was effective in removing roundworms, whipworms and hookworms (A. caninum).
- In a well-controlled laboratory study, spinosad alone began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours.
- Spinosad kills fleas on dogs before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0 to 99.8% were observed during the course of three monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
What Are The Active Ingredients In Trifexis Chewable Tablets?
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
What Is The Flavoring In Trifexis Tablets?
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.
What Is The Flavoring In Trifexis Tablets?
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1
Is Trifexis Fda Approved?
Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.
Is It Safe To Give My Breeding Dogs Trifexis?
Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.
What Side Effects Might Occur With Trifexis?
As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
What Is The Most Common Adverse Event With Trifexis?
The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.
How Quickly Will Trifexis Kill Fleas?
In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.
Will Trifexis Kill Heartworms?
Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Which Heartworm Lifecycle Stage Does Trifexis Control?
Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.
Does Trifexis Protect Against Ticks?
No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.
My Dog Has Tapeworms. Will Trifexis Get Rid Of Those?
No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
About Trifexis
Powerful Protection
Trifexis gives your dog broad spectrum protection against five common canine parasites: fleas, heartworm disease, hookworms, roundworms, and whipworms. Just one tablet provides protection that you can rely on all month long.
Neutralize Threats
Trifexis works 24/7 to kill fleas and prevent reinfestation, but the protection doesn’t stop there. It also works to prevent heartworm disease and to treat and control adult hookworm, roundworm and whipworm infections to keep your dog protected. Why settle for anything less?
Flea Treatment and Prevention
Trifexis starts killing fleas in as little as 30 minutes, completely eliminating all adult fleas within 4 hours. And it keeps on killing fleas all month, eradicating newcomers before they can ever lay eggs and cause a new infestation.
Beef-Flavored Tablet
All this powerful coverage comes in a compact and easy-to-administer beef-flavored tablet. Trifexis can be given directly by hand, placed in your dog's food bowl, or hidden in a yummy treat. Administer with food for maximum effectiveness.
Dosed By Weight
Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!
Product Guide
Trifexis offers protection for dogs in most sizes and weights. Choose the option best suited for your furry friend
5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Indication
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
Important Safety Information
The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
About Trifexis
Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
Customer Reviews
93% Recommend
93% of reviewersrecommend this product
You've Already Reviewed This Item
169 Reviews
Showing 1-10 of 169 Reviews
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Best product on the market!!!!
By Chell on May 12, 2021
My Tucker has been on Triflexis for 10yrs now, that's right when Triflexis was just getting their feet wet in the market we were one of the 1st too give it a shot & see how well it truly works, I can honestly say 10yrs later & no side effects, this product is one of the best on the market today!!! I've seen some reviews saying how they still see fleas on their furbabies but I believe they fail too realize that this product works by the fleas actually drinking our furbabies' blood 1st, within 30mins after that they die!!! Plus people need to remember too treat their homes & yards to help reduce the amount of fleas that live in our homes & yards!!! This is truly a very good product & it has protected My Tucker has been on Triflexis for 10yrs now, that's right when Triflexis was just getting their feet wet in the market we were one of the 1st too give it a shot & see how well it truly works, I can honestly say 10yrs later & no side effects, this product is one of the best on the market today!!! I've seen some reviews saying how they still see fleas on their furbabies but I believe they fail too realize that this product works by the fleas actually drinking our furbabies' blood 1st, within 30mins after that they die!!! Plus people need to remember too treat their homes & yards to help reduce the amount of fleas that live in our homes & yards!!! This is truly a very good product & it has protected Tucker for 10yrs!!! … more
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Wonderful product
By silver on Jun 11, 2021
This product has been working very well on my dog since I began using it almost 3 years ago. I've not seen one flea or tick, and there are no issues. I do have to get a bit creative when it's pill time, and hide it in her food with meat and gravy though.
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Product works as advertised, but tastes terrible
By Jonathan on Apr 7, 2021
I've been giving Trifexis to my 6 y/o Australian Shepherd mix for nearly two years and have had success with protection against heartworms, and fleas. (We live in the city, so he's not often exposed to ticks). My dog is the world's LEAST PICKY eater and usually takes any meds without issue. During this last order, however, I've struggled each month to get him to eat the pill. I'm not sure if they recently changed the formulary, but my dog immediately spits it back out. The pill is about the diameter of a dime, so I end up stuffing it into some kind of meat. I'll be switching brands on this next order.
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Good Service
By Addie on May 9, 2021
I made my first order with Chewy and was impressed with the help offered on the phone, the clarity of the ordering process and the speed in which the product showed up at my door. I've used Trifexis for many years with a number of Labradors so I knew what I was asking for.
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Very Trusted
By Wilkie on Apr 9, 2021
Fist time ordering my dogs med was extremely easy by just following the instructions Chewy set up. They checked with my vet about her prescription, for me the price was great. Had it delivered the next day or two right to my door.
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This stuff works
By Cash on Apr 1, 2021
It’s a no fail treatment. Always works great. No sing of fleas and it’s a great safe alternative to drops. My pets are happy with all our purchases from Chewy. This is no exception. And I’m happy to have a no hassle option. Shipping is fast!
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Worked - but my dog was really drowsy!
By Dani on Jan 21, 2021
First of all - this pill is HUGE! I tried hiding it in a pile of shredded cheese which is usually a fool proof method for giving medications to my 45lb goldendoodle, but she knew something was suspicious. Finally we were able to get her to swallow it after carefully wrapping it inside an envelope of American cheese. I was concerned when I noticed how drowsy she was a few hours later. She didn’t have any other side effects (like vomiting, etc.), she was just really sleepy for a few hours. Overall, it did its job killing off the fleas and I like that it covers her for heart worm and other parasites. I wish I was effective against ticks, though. Next time I will try to make sure she eats more food First of all - this pill is HUGE! I tried hiding it in a pile of shredded cheese which is usually a fool proof method for giving medications to my 45lb goldendoodle, but she knew something was suspicious. Finally we were able to get her to swallow it after carefully wrapping it inside an envelope of American cheese. I was concerned when I noticed how drowsy she was a few hours later. She didn’t have any other side effects (like vomiting, etc.), she was just really sleepy for a few hours. Overall, it did its job killing off the fleas and I like that it covers her for heart worm and other parasites. I wish I was effective against ticks, though. Next time I will try to make sure she eats more food before taking it to see if that helps with the drowsiness. … more
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Fleas and Ticks stay away
By Izzy on Jun 9, 2021
Received package quickly. Smooth transaction. Will purchase from Chewy.com again. Thank you.
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Great product, fast delivery
By CNH82 on Jan 14, 2021
We’ve used Trifexis since our almost 8 year old dog was just a pup. It does what we need it to do! That’s why we continue to use it. As far as ordering from Chewy, I was a little nervous after reading reviews about getting prescriptions approved and what not but it only took 2 days (one of those days was New Years) to get an email saying the prescription was approved by our vet! From order to deliver it was about a week (with a holiday in there). I was pretty impressed to say the least. Needless to say we will be using Trifexis and Chewy for the foreseeable future!
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Doesn't protect from ticks
By Lilly on Mar 1, 2021
For a broad-spectrum flea preventative it should protect against ticks and it doesn't. Im still finding fleas on my dog so I won't be purchasing this again. It's nice for the heart guard but Samparica trio does it all and im going to try that next.
