Trifexis Chewable Tablet for Dogs, 5-10 lbs, (Magenta Box)

By Trifexis
Rated 4.5935 out of 5 stars
Prescription Item

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$122.68Chewy Price
$116.55Autoship Price
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FREE delivery
Usually arrives in 3-5 days
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This item requires prescription approval.

Medications ship separately. Delivery times may vary.

About This Item


Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

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About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
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ReviewsWrite a Review

Rated 4.5935 out of 5 stars
123 Ratings
Would recommend to a friend

116 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 5 out of 5 stars
By Brenda on Oct 12, 2023

Good so far!

Just started my 4 year old puppies on Trifexis. So far working well with no adverse side effects. Left getting prescription from my Vet to Chewy and got free shipping as well ;)

Rated 5 out of 5 stars
By Stella on Nov 18, 2023

Happy puppies

I love chewy and so does my puppies. Best service and great quality of everything you get

Rated 5 out of 5 stars
By Marsha on Nov 25, 2023

Helpful Product

Seems to aid in controlling fleas and worms and is easy to give my Chihuahua.

Rated 5 out of 5 stars
By George on Nov 21, 2023

Excellent product

I have used this product for years and have had no issues with heart worms

Rated 5 out of 5 stars
By Beefume on Jul 31, 2023

17 here she comes!

Our littlest love is 16 years old going on 17 in October! Trifexis has protected her for her entire life! Zazz has a double coat so fleas can get lost in there but with trifexis their days are numbered!

Rated 3 out of 5 stars
By Maisie on Aug 12, 2023
Top 100 Contributor


I didn’t realize that this doesn’t protect against ticks. I’m so disappointed and now I have five months left to give this to my dog. We live in a high tick area too.

Rated 5 out of 5 stars
By Paul on Nov 14, 2023


Used for years with different dogs. Does the job nicely..

Rated 5 out of 5 stars
By diane on May 7, 2023

great service and products

if you want great products and service at a good price this is the place3.

Rated 5 out of 5 stars
By Mary on Oct 31, 2023


We love Chewy

Rated 2 out of 5 stars
By Shaggy on Nov 12, 2022

Fleas still active

I used this product over the summer for my Cavalier. I used a different product for my Boston Terrier. Cavalier had consistent fleas throughout summer on his coat, the Boston did not.