TRIFEXIS Chewable Tablet for Dogs, 5-10 lbs, (Magenta Box), 6 Chewable Tablets (6-mos. supply) -

Trifexis Chewable Tablet for Dogs, 5-10 lbs, (Magenta Box)

By Trifexis
Rated 4.5472 out of 5 stars
Prescription Item
Pet Weight

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$119.69Chewy Price
$122.68Chewy Price
$113.71Autoship Price
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About This Item


Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Proudly sourced directly from the manufacturer or their approved distributor. Guaranteed genuine and backed by the manufacturer.

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Play Video: Learn More About Trifexis From Our Team of Experts
Learn More About Trifexis From Our Team of Experts

About Trifexis

Dosed By Weight

Trifexis comes in five different strengths to provide custom-tailored dosing for a wide range of dogs. Just one tablet provides the correct amount your pup needs to protect him for a whole month from 5 different types of parasites. Trifexis works for dogs 8 weeks and older, with dosing for dogs from 5 pounds to 120 pounds—and beyond!

5 - 10 LBS
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10.1 - 20 LBS
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20.1 - 40 LBS
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40.1 - 60 LBS
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60.1 - 120 LBS
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Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.

Important Safety Information

The use of ivermectin at higher than FDA-approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, redose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
Trifexis Product Label

About Trifexis

Trifexis is a once-a-month, beef-flavored tablet that provides broad protection against a range of parasites. It kills fleas, prevents flea infestations, prevents heartworm disease, and treats and controls adult hookworm, roundworm, and whipworm infections. Protect your dog with convenient parasite protection that lasts all month long.
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ReviewsWrite a Review

Rated 4.5472 out of 5 stars
106 Reviews
Would recommend to a friend

106 Customer Reviews

Rated 2 out of 5 stars
By Shaggy on Nov 12, 2022

Fleas still active

I used this product over the summer for my Cavalier. I used a different product for my Boston Terrier. Cavalier had consistent fleas throughout summer on his coat, the Boston did not.

Rated 5 out of 5 stars
By Soraida on Feb 2, 2023

Trifexis is the best

Works great for my pups. Chewy is fast, reliable and less expensive.

Rated 5 out of 5 stars
By Adara on Jun 19, 2022

First dosage excellent

Yo, I've been living with fleas for over six months, finally was able to get to a vet to get approval. This was worth every penny!! My dog had no issue with the pill, and looked at me like she wanted more. Huge results in a matter of a hour, let alone my dog seems much happier!

Rated 4 out of 5 stars
By Liljs on Jun 12, 2022

Good service

First time using Chewy.Was very easy to order online & even called to make a quick change, everyone was courteous & delivery was quick. Just wish the price was a little lower.

Rated 5 out of 5 stars
By DoggieMeds on Mar 18, 2022

Make it easy on yourself.

I order the Trifexis for heartworm, fleas, ticks and intestinal worms, my dog is 12 yrs old and I want to protect her as best I could. Ordering this from Chewy is fast and easy, I don't even have to leave my house. It's shipped within a few days. The customer service at Chewy's is professional and courteous, so make it easy on yourself.

Rated 5 out of 5 stars
By Trifexis on Feb 10, 2022

Super product!

I love the easy way to order products for my dogs and the quality of the products. The only thing I would change is the cost of the product, for me it’s a little more than I was expecting to pay but the product quality can’t be beat. My 3 babies are well protected.

Rated 5 out of 5 stars
By fleafree on Feb 3, 2022

Trifexis works!

First time ordering from Chewy - gave them my vet's number and they took care of the rest. Order actually came in sooner than expected. I have 2 dogs and Trifexis is perfect for them - no side effects. Definitely recommend this product.

Rated 3 out of 5 stars
By RKing on Dec 28, 2021


I love the affordability and simplicity of giving 1 pill to cover everything, but my fur babies do not like the taste. Come on Trifexis. Can't you all do something to make it taste better? Thanks

Rated 5 out of 5 stars
By Bentley on Dec 6, 2021

My picky eater yorkie loves it

Super easy to give to my yorkie, he’s very picky and I don’t have to hide the pill in food. I’m also giving 5 stars for customer service because one time there was an issue and they gave me a refund. Also super fast shipping

Rated 5 out of 5 stars
By Docblues69 on Mar 20, 2022

No bugs on my dogs!

Best price Great product Came quickly and well packaged