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Most prescriptions are delivered within 3-5 days.Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.
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Item Number | 146165 |
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Common Brand Name(s) | Trifexis, Comfortis |
For Use With | Dogs |
Generic Name | Spinosad, Milbemycin Oxime |
Administration Form | Oral |
Repels or Prevents | Fleas, Heartworms |
Kills or Treats | Fleas, Roundworms, Hookworms, Whipworms |
Breed Size | Extra Small Breeds |
Product Form | Chewable Tablet |
Strength | 140 mg Spinosad and 2.3 mg Milbemycin Oxime |
Health Condition | Heartworms, Fleas, Hookworms, Roundworms, Whipworms |
Drug Type | Parasiticide |
Trifexis prevents heartworm disease. Trifexis kills fleas and prevents flea infestations, and treats and controls adult hookworm, roundworm and whipworm infections in dogs and puppies 8 weeks and older and 5 pounds or more.
When used as prescribed, side effects while using Trifexis are rare. Symptoms of gastrointestinal distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.
Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.
The use of ivermectin at higher than FDA approved doses at the same time as Trifexis can result in serious side effects. Treatment with fewer than three monthly doses after the last exposure to mosquitoes may not provide complete heartworm prevention. Prior to administration of Trifexis, dogs should be tested for existing heartworm infection. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. The most common adverse reactions reported are vomiting, decreased activity, itching, decreased appetite, and diarrhea. To ensure heartworm prevention, observe your dog for one hour after administration. If vomiting occurs within an hour of administration, re-dose with another full dose. Puppies less than 14 weeks of age may experience a higher rate of vomiting. For complete safety information, please see Trifexis product label or ask your veterinarian.
140 mg Spinosad and 2.3 mg Milbemycin Oxime.
Trifexis is a beef-flavored chewable tablet and may be given from your hand, mixed in with food or placed in a treat. Give Trifexis with food for maximum effectiveness. To ensure heartworm prevention, observe your dog for one hour after dosing. If your dog vomits within an hour of administration, re-dose with another full dose.
Administer one tablet once every month to provide year-round protection for dogs and puppies 8 weeks and older and 5 pounds or greater. If you miss a dose, immediately administer Trifexis with food and resume monthly dosing. This will minimize the opportunity for heartworm infection. Also, continuing normal monthly dosing will help allow you to gain control of any flea infestation or intestinal parasite infection that might have affected your dog.
Store at controlled room temperatures between 68° - 77°F.
Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.
Spinosad and milbemycin oxime are the two active ingredients in Trifexis.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.
The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1
Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.
Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.
As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.
The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.
In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.
Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.
Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.
No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.
No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.
I used this product over the summer for my Cavalier. I used a different product for my Boston Terrier. Cavalier had consistent fleas throughout summer on his coat, the Boston did not.
Works great for my pups. Chewy is fast, reliable and less expensive.
Yo, I've been living with fleas for over six months, finally was able to get to a vet to get approval. This was worth every penny!! My dog had no issue with the pill, and looked at me like she wanted more. Huge results in a matter of a hour, let alone my dog seems much happier!
First time using Chewy.Was very easy to order online & even called to make a quick change, everyone was courteous & delivery was quick. Just wish the price was a little lower.
I order the Trifexis for heartworm, fleas, ticks and intestinal worms, my dog is 12 yrs old and I want to protect her as best I could. Ordering this from Chewy is fast and easy, I don't even have to leave my house. It's shipped within a few days. The customer service at Chewy's is professional and courteous, so make it easy on yourself.
I love the easy way to order products for my dogs and the quality of the products. The only thing I would change is the cost of the product, for me it’s a little more than I was expecting to pay but the product quality can’t be beat. My 3 babies are well protected.
First time ordering from Chewy - gave them my vet's number and they took care of the rest. Order actually came in sooner than expected. I have 2 dogs and Trifexis is perfect for them - no side effects. Definitely recommend this product.
I love the affordability and simplicity of giving 1 pill to cover everything, but my fur babies do not like the taste. Come on Trifexis. Can't you all do something to make it taste better? Thanks
Super easy to give to my yorkie, he’s very picky and I don’t have to hide the pill in food. I’m also giving 5 stars for customer service because one time there was an issue and they gave me a refund. Also super fast shipping
Best price Great product Came quickly and well packaged