Loading...
Loading...

Trifexis Chewable Tablets for Dogs, 40.1-60 lbs, 6 treatments

Prescription Item

  • List Price:

    $120.00

  • Price:

    $113.99

  • You Save:

    $6.01 (5%)

In stock

This item requires prescription approval. Details

Medications ship separately. Delivery times may vary. Details

We'll collect your pet's prescription information at Checkout.

cw-icon-heart Created with Sketch. Add to Favorites
Description

Your furry friend must have a current heartworm test result on file with your veterinarian in order to be prescribed heartworm medication. Please visit your veterinarian to have this test performed annually to protect your four-legged friend. Trifexis (spinosad + milbemycin oxime) is the monthly, beef-flavored tablet prescribed to kill fleas and prevent flea infestations, prevent heartworm disease, and treat and control adult hookworm, roundworm and whipworm infections in dogs. With flea medicine, heartworm preventive and intestinal parasite control in one, get the peace of mind that comes from protecting your canine companion.

Uses

Trifexis is indicated to prevent heartworm disease, kill fleas, prevent flea infestations, and treat/control adult hookworm, roundworm, and whipworm infections.

Possible Side Effects

When used as prescribed, side effects while using Trifexis are rare. Symptoms of GI distress and skin irritation can occur. Vomiting, diarrhea, lethargy, lack of appetite, and itching and reddening of the skin have been reported. Vomiting may be more likely in puppies under 14 weeks of age. If your dog is truly allergic to Trifexis or to the dying of parasites, she may exhibit symptoms such as facial swelling, hives, scratching, sudden onset of diarrhea, vomiting, shock, seizures, pale gums, cold limbs, or coma. If your dog experiences any of these symptoms, call your veterinarian or a local emergency veterinarian immediately.

Drug & Food Interactions

Always communicate with your veterinarian about any medications, vitamins, or supplements your dog is already taking. Some serious adverse reactions have been documented when used with other spinosad and ivermectin medications simultaneously. No known food interactions have been reported.

Precautions

Before receiving Trifexis, your dog should be tested for existing heartworm. Your veterinarian will recommend treatment to remove adult heartworms; Trifexis is not effective against adult heartworm infestations. Use with caution in breeding females. The safe use of Trifexis in breeding males has not been evaluated. Use with caution in dogs with pre-existing epilepsy. Puppies less than 14 weeks of age may experience a higher rate of vomiting. Not for human use. Keep this and all drugs out of the reach of children. Serious adverse reactions have been reported following concomitant extra-label use of ivermectin with spinosad alone, a component of Trifexis.

  1. Package Insert

See all items by Trifexis

  • Item Number
    146171
  • Dosage Measure

    Use according to your veterinarian's instructions.

  • Common Brand Name(s)

    Trifexis, Comfortis

  • For Use With

    Dogs

  • Generic Name

    Spinosad, Milbemycin Oxime

  • Brand

    Elanco

  • Breed Size

    Medium Breeds, Large Breeds

  • Product Form

    Chewable Tablet

  • Health Condition

    Heartworms, Fleas, Hookworms, Roundworms, Whipworms

  • Drug Type

    Parasiticide

Ingredients
Ingredients

Spinosad and Milbemycin Oxime

Instructions
Recommended Dosage

Trifexis is given to dogs monthly as directed by your veterinarian to prevent heartworm disease and protect your dog from fleas and other pest infestations.

Storage Instructions

Store at controlled room temperatures between 68° - 77°F.

Administer one tablet once every month to provide year-round protection for dogs and puppies 8 weeks and older and 5 pounds or greater. If you miss a dose, immediately administer Trifexis with food and resume monthly dosing. This will minimize the opportunity for heartworm infection. Also, continuing normal monthly dosing will help allow you to gain control of any flea infestation or intestinal parasite infection that might have affected your dog.

FAQ

What Is Trifexis (Spinosad + Milbemycin Oxime), And What Does It Protect Against?

Trifexis is a monthly, chewable tablet for dogs. Trifexis kills fleas and prevents flea infestations on dogs, treats and controls adult hookworm*, whipworm and roundworm infections, and prevents heartworm disease. Trifexis is for use in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater. If you do not administer Trifexis monthly throughout the year, continue administering the medication for at least three months following the last exposure to mosquitoes.

What Are Some Of The Benefits Of Trifexis?

  • Trifexis is an oral monthly product that rapidly kills fleas on dogs and is effective in preventing heartworm disease and treatment and control of adult hookworm (A. caninum), adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight and greater.
  • Trifexis is approved by the FDA as safe and effective when used according to the label.
  • Spinosad, one of the active ingredients in Trifexis, began to kill fleas on dogs 30 minutes after administration with 100% effectiveness within 4 hours in a well-controlled laboratory study.
  • Trifexis continues to kill fleas for a full month after treatment.
  • Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.
  • Trifexis is available in five strengths. Each tablet is formulated to provide a minimum dosage of 13.5 mg/lb (30 mg/kg) spinosad and 0.2 mg/lb (0.5 mg/kg) milbemycin oxime according to body weight.

How Well Does Trifexis Work?

  • In a well-controlled laboratory study, Trifexis was 100% effective against induced heartworm infections in dogs when administered for three consecutive monthly doses.
  • In well-controlled laboratory studies, a single dose of Trifexis at labeled dose was effective in removing roundworms, whipworms and hookworms (A. caninum).
  • In a well-controlled laboratory study, spinosad alone began to kill fleas 30 minutes after administration and demonstrated 100% effectiveness within 4 hours.
  • Spinosad kills fleas on dogs before they can lay eggs. If a severe environmental infestation exists, fleas may persist for a period of time after dose administration due to the emergence of adult fleas from pupae already in the environment. In field studies conducted in households with existing flea infestations of varying severity, flea reductions of 98.0 to 99.8% were observed during the course of three monthly treatments with spinosad alone. Dogs with signs of flea allergy dermatitis showed improvement in erythema, papules, scaling, alopecia, dermatitis/pyodermatitis and pruritus (itching) as a direct result of eliminating the fleas.

What Are The Active Ingredients In Trifexis Chewable Tablets?

Spinosad and milbemycin oxime are the two active ingredients in Trifexis.

What Is The Flavoring In Trifexis Tablets?

The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.

What Is The Flavoring In Trifexis Tablets?

The flavoring in Trifexis comes from artificial beef flavoring made from pork-based proteins and hydrolyzed soy.1

Is Trifexis Fda Approved?

Yes, Trifexis is a prescription medicine approved by the Food and Drug Administration and should be obtained only through a licensed veterinarian with whom you have a proper veterinarian-client-pet relationship.

Is It Safe To Give My Breeding Dogs Trifexis?

Ask your veterinarian about the use of Trifexis prior to use in breeding females. The safe use of Trifexis in male dogs intended for breeding has not been evaluated.

What Side Effects Might Occur With Trifexis?

As with all medicines, sometimes side effects may occur. In some cases, dogs vomited after receiving Trifexis. If vomiting occurs within an hour of administration, redose with another full dose. During field studies, no severe or prolonged vomiting occurred. Additional adverse reactions observed in the clinical studies were itching, decreased activity, diarrhea, inflammation of the skin, redness of the skin, decreased appetite and redness of the ear. All reactions were regarded as mild.

What Is The Most Common Adverse Event With Trifexis?

The most common adverse reactions based on post-approval adverse drug event reporting are vomiting, depression/lethargy, pruritus, anorexia, trembling/shaking, atazia, seizures, hypersalivation and skin reddening.

How Quickly Will Trifexis Kill Fleas?

In a laboratory study of spinosad alone, this active ingredient of Trifexis started to kill fleas within 30 minutes and killed 100% of the fleas on dogs within 4 hours. Trifexis kills fleas before they can lay eggs.

Will Trifexis Kill Heartworms?

Trifexis prevents heartworm disease in dogs by killing certain stages that develop after an infected mosquito bites a dog. As with other heartworm preventives, Trifexis does not kill adult heartworms. Speak to your veterinarian about treatment options if your dog is diagnosed with an adult heartworm infection.

Which Heartworm Lifecycle Stage Does Trifexis Control?

Trifexis acts in the same way as other monthly heartworm preventives, by killing L3 and L4 larval stages before they molt to the final adult stage.

Does Trifexis Protect Against Ticks?

No, Trifexis is not labeled to kill or repel ticks. Trifexis is labeled for the prevention of heartworm disease on dogs, to kill adult fleas on dogs and to treat and control adult hookworm, roundworm and whipworm infections in dogs. There are no known contraindications between Trifexis and medications commonly used against ticks.

My Dog Has Tapeworms. Will Trifexis Get Rid Of Those?

No, Trifexis will not treat a tapeworm infection. Trifexis is indicated for the prevention of heartworm disease in dogs, for the prevention and treatment of flea infestations on dogs and the treatment and control of adult hookworm, adult roundworm and adult whipworm infections in dogs and puppies 8 weeks of age or older and 5 pounds of body weight or greater.

>
Customer Reviews
34 Reviews 34 Reviews 4.9 out of 5 Stars

100% Recommend

100% of reviewersrecommend this product

4.9 / 5

You've Already Reviewed This Item

Showing 1-10 of 34 Reviews

  • Just gave to my dog today

    By on

    I just gave this to my large German shepherd puppy today, I’m not entirely sure if it works yet however the pill was quite large but he ate it no problem. He is a very picky eater and absolutely loved this chewable tablet. I will update my review in a couple months if this works on my baby or not as yard is very heavily infested with fleas and ticks and so far it’s been nearly impossible trying to keep him flea free.

    You liked it! Something went wrong. Please try again later. Report
  • Reliable preventive for heartworm, fleas and other parasites

    By on

    I am pleased with the protection provided by Trifexis as well as the low price and timely delivery provided by Chewy. My only problem is that neither of my dogs will take the tablets unless I disguise their unpleasant taste. I have to wrap them in Pill Pockets so they will eat them. Please note the potential side effects of the formula and administer tablets when you will be home with them to monitor their reaction.

    You liked it! Something went wrong. Please try again later. Report
  • Good product experience

    By on

    I’ve been using this product for a year and it works great. No side effects noticed with my dog either. Tablets come individually packaged for easy dispensing. Purchasing is easy as Chewy contacts my Vet. for prescription verification. The order always comes as stated.

    You liked it! Something went wrong. Please try again later. Report
  • Chewy's...the BEST!

    By on

    We have used Chewy's for years...love the company. They have the best customer service along with prices that beat any other. Always pleased with my products. What I like the most is all is delivered to my door! Autoship works well for us...on time...every time.

    You liked it! Something went wrong. Please try again later. Report
  • Way faster than a vet visit!

    By on

    I am extremely happy with the way this order went. Getting my vet to send the prescription was fast and easy, now with autoship, I don't have to bring my dog in to get weighed every six months. One less worry. Thanks Chewy!

    You liked it! Something went wrong. Please try again later. Report
  • Great and unbeatable!

    By on

    I purchased trifexis, dog food, and red barn natural roll (treats) and I’m thrilled about the lower cost! I have 3 dogs and keeping up a routine with them takes some endurance! I love chewy.

    You liked it! Something went wrong. Please try again later. Report
  • good product, GREAT service

    By on

    Been using Trifexis for a long time and it seems to get the job done. We have no problems with heart worms or fleas. I think it's great that Chewy now handles prescriptions as I have learned to trust the people at Chewy and enjoy the great service they provide.

    You liked it! Something went wrong. Please try again later. Report
  • So convenient!

    By on

    Our dog Mocha has been on Trifexis for years. I love that it includes both flea and heart worm protection in one dose. Buying through Chewy was also considerably cheaper that buying from the vet.

    You liked it! Something went wrong. Please try again later. Report
  • Trifexis 40-60 lbs

    By on

    I have been using Trifexis for several years and it is a great product. The price from Chewy.com is so much better than my Veterinary Hospital and the Autoship makes it so easy.

    You liked it! Something went wrong. Please try again later. Report
  • never change

    By on

    mileys been on Trifexis for almost 5 years now. we have never found a flea on her or has she ever come up poisitve for heartworm or any other kinds of parasites

    You liked it! Something went wrong. Please try again later. Report