Vectra 3D Flea & Tick Spot Treatment for Dogs, 21-55 lbs

By Vectra
Rated 3.6509 out of 5 stars

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$42.25Chewy Price
$54.99Chewy Price
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$12.74 (23%)
$40.14Autoship Price
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About This Item


  • This monthly treatment helps protect dogs ages 8 weeks and older weighing 21–55 pounds from fleas, ticks, mosquitoes, lice, mites plus biting and sand flies—excluding mange mites.
  • Starts to reduce flea bites in five minutes and kill fleas in four hours.
  • Works to repel and kill fleas, ticks and mosquitoes–no biting required!
  • This easy-to-apply topical treatment is quick drying, fragrance free, non-greasy and waterproof after 24 hours.
  • No prescription required.

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Play Video: Learn More About Vectra From Our Team of Experts
Learn More About Vectra From Our Team of Experts

Important Information

Fleas rise to the top of your pet's coat as they die, so consider it a triumph if you start seeing more fleas at first, after treating your pet. If you’re still seeing fleas after application, it may be because your pet has picked up new fleas from the environment, which may include other pets, surfaces and outdoor areas. It may take up to 30 days to break the entire flea life cycle. Additionally, you should also treat sources of new fleas (i.e., carpet, yard, etc.) to ensure complete flea control.

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Top IngredientsDinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Dinitefuran, Pyriproxyfen, Permethrin.Active Ingredients : Fipronil 9.8% , (S)-methoprene 8.8%.
LifestagePuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, Senior
Breed SizeMedium BreedsLarge BreedsSmall BreedsExtra Small BreedsSmall Breeds, Medium Breeds

Questions & Answers

10 Customer Questions

My dog weighs 106. Can I use 2 of the 21-55 tubes at once

Do I treat my dog with 3 doses right away, or use one dose a month?
Answer by ChewyMay 06, 2020
This flea and tick treatment should be administered once a month.

Some products that are safe for dogs are NOT safe for use around cats. I have 2 dogs and 1 cat is it safe to use on the dogs with a cat in the house?
Answer by ChewyJun 22, 2020
Due to their unique physiology and inability to metabolize the permethrin in Vectra 3D® for Dogs, this product must not be used on cats. As a precaution, when using this product in households with both dogs and cats, please keep the dog(s) that have been treated with a Vectra 3D® product separated from cats until the product has completely dried. Once dry, cats and dogs may again interact freely. Average drying time for Vectra 3D is 6-8 hours however drying times can vary. To ensure that the product is completely dry, you may run a facial tissue along the application site. When there is no evidence of moisture on the tissue, the product is dry.

Does this need veterinarian approval?
Answer by ChewySep 18, 2019
This treatment does not require a prescription.

ReviewsWrite a Review

Rated 3.6509 out of 5 stars
106 Ratings
Would recommend to a friend

104 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.
Rated 2 out of 5 stars
By Mary on Nov 13, 2023

Won't use again

I hate putting chemicals on my dogs, but just pulled a tick out of one and vets insist on a preventative. So I bought this for both my pups, because I could use the same amount for both and buy just one box (30lbs and 52lbs). The larger dog is fine, no adverse reaction. The smaller dog has been curling his back, holding tail to the side, and frequently shaking off his fur. I think this is burning his skin. From what I've read there are worse reactions, so I guess I'm lucky. My dog is also on Prednisone though for another condition, so that might be calming his skin reaction. I bathed my dog after 3 days on Vectra, and it made no difference, but in researching more I guess I should have used dish soap. So this will be washed off, hopefully, but a waste of money and hopefully no harm to the dog. Back to natural tick repellent products and treating my lawn instead of my dogs - although I believe my dog picked this tick up at a local park, not my yard. I inspected him daily, but missed this tick entirely.

Rated 5 out of 5 stars
By Nancy on Nov 12, 2023

Good as always

The young pup i rescued needed flea treatment. He is now in another home. Mr Bill was Charms favorite toy, I got it to remember her by. I am too ill to train another service dog. You’ve been great to buy from for many years and I’ll always recommend you.

Rated 5 out of 5 stars
By Beth on Nov 18, 2023

Great Flea, Tick & Mosquito Repellent

Just want to shout out that this is an excellent product. I walk in a forested area daily that is loaded with ticks. My dog never seems to pick up any where other dogs in the pack we walk with have them often.

Rated 1 out of 5 stars
By NoNamePup on Nov 9, 2023

Dog scratches like crazy

My 2 year old is scratching her belly area and snout like crazy. Vet recommended Benadryl. We have not changed anything except for this item. Will be trying something else, probably Simparica, next month.

Rated 1 out of 5 stars
By Ryan on Nov 15, 2023

Tubes leak everywhere, makes a mess and wastes the product. Chewy was great and sent me a replacement pack, thinking it was just a faulty batch, but the new ones leaked too.

Rated 1 out of 5 stars
By Disappointed on Sep 2, 2023

does not work

Tried and gave this brand a chance but it does nothing to work to solve the fleas on my dog. This is the first year battling fleas ever and I have also treated yard and home along with this product. Don’t waste you’re money.

Rated 5 out of 5 stars
By CHARLES on Jul 11, 2023

no ticks

This product works great! First year that I have no ticks. I have always gave my dogs the digestive tick medicine to find out that it doesn't provide effective Lyme disease for the full three months and now my dog has Lyme disease, plus the ticks always came in the house and I got tick bites. This product repels ticks or kills ticks and none of us have ticks!

Rated 5 out of 5 stars
By Angela on Apr 30, 2023


Kind of a pain to apply, because you have to get it directly on the skin all the way from the neck to base of tail. Then when you're done it does leave some wet residue in your dog's hair, which you're not supposed to touch until it's dry. My dog was told to use this by his vet, and we have been and it seems to work just fine, but it does make his back itchy. I just wait until its fully dry and brush/scratch his back. But we havent had any issues with flea or ticks, etc.

Rated 5 out of 5 stars
By Kobi on Apr 28, 2023

A Very Good Product

We first used Vectra 3D about 13 years ago when we lived in Maryland. Fleas got out of hand, they were everywhere and our regular flea/tick product did nothing. I researched flea/tick topical products for a long time and found Vectra to be one of the least toxic to dogs and still do the job. We've stuck with Vectra ever since and no fleas or ticks. We now live in the middle of the woods on a mountain, so a good test area.

Rated 5 out of 5 stars
By Winston on Sep 5, 2023


Ordering was easy, shipping and tracking was easy, communication good. I like Chewy!