Vetadryl (Diphenhydramine HCl) Tablets for Dogs & Cats, slide 1 of 1

Vetadryl (Diphenhydramine HCl) Tablets for Dogs & Cats

Prescription Item

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Strength: 10-mg
  • Click to select 30-mg In stock
Count: 30 count
  • Click to select 250 count In stock

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Medications ship separately. Delivery times may vary. Details

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If your pet struggles with seasonal allergies, Vetadryl may be able to help. These easy-to-feed, flavored, chewable tablets are specifically formulated to help with the unpleasant symptoms of allergies, and they may also help relieve motion sickness, as well as the symptoms of bug bites. Vetadryl is available in two strengths to easily dose your pet at the strength he needs for relief.


For use in animals where antihistamine treatment is indicated.

Possible Side Effects

Side effects that usually are not serious include: The most common side effect, which is often desirable, is sleepiness. Most animals will become tolerant to this effect with time and will not get as sleepy when given the medication. Cats, in particular, may become unusually excited while taking this drug. Dry mouth and trouble urinating (eg, straining) are possible but not common. Infrequently, diphenhydramine may cause gastrointestinal distress such as vomiting, decreased appetite, or diarrhea. You don’t have to be overly concerned if you see any of these signs unless they are severe, worsen, or continue to be a problem. Contact your veterinarian if this happens.

Drug & Food Interactions

No serious Food and Drug Interactions have been reported.


For oral use only. Use under veterinary supervision. Common side effects may include sedation, ataxia, reduced coordination, gastric upset, thickening of bronchial secretions, and increased urine output. Do not use in patients with known hypersensitivity to diphenhydramine, other antihistamines with similar chemical structure, or any ingredient in the formulation. Use with caution in patients with glaucoma, history of gastric irritation or ulcer, bowel or bladder obstruction, prostatic hypertrophy, active or a history of lower respiratory disease (e.g., bronchial asthma), hyperthyroidism, seizures or cardiovascular disease (e.g., hypertension).

This product now requires a veterinary prescription to ship. Simply provide your vet's information during checkout and we'll follow up to confirm the prescription.

  1. Prescribing Information

See all items by Vetadryl

  • Item Number
  • For Use With
    Dogs & Cats
  • Generic Name
    Diphenhydramine Hydrochloride
  • Common Brand Name(s)
  • Administration Form
  • Brand
    PRN Pharmacal
  • Breed Size
    All Breeds
  • Product Form
    Chewable Tablet
  • Health Condition
    Allergies, Motion Sickness
  • Drug Type

Diphenhydramine HCl (10 mg), Dried Chicken Liver Flavoring.

Recommended Dosage

Use according to your veterinarian's instructions.

Storage Instructions

Store at room temperature 59-86°F.


What is Vetadryl?

Vetadryl is a liver-flavored diphenhydramine HCl tablet formulated in strengths specifically for dogs and cats – to minimize the risk of administering the incorrect amount, which can harm your pet. Tablet strengths are available in 10mg and 30mg for flexible dosing.

Rating: 4.1 of 5 stars 5 Reviews 5 Reviews 4.2 out of 5 Stars

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80% Recommend

80% of reviewersrecommend this product

Rating: 4.1 of 5 stars 4.2 / 5

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5 Reviews

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  • 5 out of 5 stars

    I use it for grass allergy

    By on

    This is very affordable & much easier to give to my dog than the bitter Benadryl. Grass allergy: I start dosing in late Feb to get it into her system, with fish oil & vit E. If a little irritation develops, (inside ears) I wipe with Neem oil. I’ve used this for many years & this is the first time a prescription was required. Chewy made it very easy to order. I received it quickly.

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  • 5 out of 5 stars

    Tasty medicine

    By on

    Finally a medication that my dog will take! My dog with pancreatitis will pick through her food and treats to find the pills and spit them out. These supposedly taste like meat. She won’t take them as a treat but will eat them along with her food no problem. No unusual drowsiness either. Wish every dog pill could be made this way.

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  • 5 out of 5 stars

    Doggie Benedryl

    By on

    It's a great product . It comes in a small enough dose so you don't have to resort to another product.

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  • 1 out of 5 stars

    Not what you think as a chewable

    By on

    I bought these because my AmStaff is constantly getting mast cell tumors. As they're histamine related my vet thought a regimen of Benadryl might reduce the frequency of occurrence. Technically these are probably chewable tablets I suppose. But they're small and hard, like a typical small aspirin tablet and my dog just spits them out because they're too small to chew. Something larger like a training treat that's a bit soft would be perfect.

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  • 5 out of 5 stars

    Best ever!

    By on

    These are amazing. Stopped the itching AND helped to relax dogs so I could trim nails!

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