Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats

By Vetoquinol
Rated 3.9344 out of 5 stars


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$33.99Chewy Price
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About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 75 mg capsules that can be given by mouth, or opened and mixed with a meal.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule)...Active Ingredients: Hydrolyzed Milk Protein Powder, Chamomile Powder, Valerian Root Powder...Dried Hydrolysed Casein, Maltodextrin, Magnesium Stearate.Active Ingredients: Thiamine, L-Tryptophan, Chamomile Extract...Active Ingredients: Ashwagandha root (Withania somnifera), Wild Oat seed (Avena fatua), Holy Basil leaf (Ocimum sanctum)...
Breed SizeExtra Small Breeds, Small BreedsMedium BreedsLarge Breeds, Giant BreedsExtra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...
Health FeatureCalmingCalmingCalmingCalmingCalming
LifestagePuppy, Kitten, Adult, SeniorAdultPuppy, Adult, SeniorPuppy, Kitten, Adult, SeniorAdult
Food FormSupplementSupplementSupplementSupplementSupplement
Food FlavorChickenUnflavoredUnflavoredMeat, Bacon

Questions & Answers

30 Customer Questions

Can this be given long term for severe anxiety?
Answer by ChewyJan 04, 2018
This Supplement is intended for short term use. Use as recommended by your veterinarian.

I'm moving and am taking my 2 cats and 3 dogs with me.. would this help them for an 18 hour drive?
Answer by ChewySep 20, 2018
This is perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.

Are any of the ingredients made or obtained from China? Where is this manufactured?
Answer by ChewyNov 07, 2019
This product is sourced in Canada and manufactured in the USA.

Is this for dog depression??
Answer by ChewyOct 25, 2017
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs and cats safely and with no tranquilizing or sedating effects.

ReviewsWrite a Review

Rated 3.9344 out of 5 stars
366 Ratings
Would recommend to a friend

361 Customer Reviews

Rated 3 out of 5 stars
By Audrey on Oct 22, 2023

Zylkene was not effective enough for our three cats

Our vet recommended Zylkene as one of three possible products to try. We are introducing a new cat to the household who is considerably younger than the other two. He's just barely a year old. They are 18 and 12. He's big, strong, and gets overstimulated very quickly. He also escaped from his "apartment" one day and chased and injured the 12-year-old female. At first, I thought Zylkene was working a bit. I was giving it to the new boy - Rafe - and the female. Then it became clear that Rafe was not calmed very much. Zylkene is only to be used for a short time and for a maximum of two times a day. Since we couldn't increase the dosage, we needed to move to another option. We are now trying 2 others, which I'll review as we find out more4. Zylkene might work for your felines, but, alas, it didn't work for us.

Rated 5 out of 5 stars
By Sarah on Oct 27, 2023

it works

I rescued my puppy from the pound and she is a little psycho. Nervously pees every time someone comes near her too "aggressively", cannot go in public without losing control of ALL of her bowels and then starts vomiting as well. Vet recommended this and she's been taking it for about a month now. She's still psycho but her fearful peeing and pooping has become less, we even took her to some family's house for the weekend and she got along with the other dog that was there. I'm impressed with how it has worked for her.

Rated 5 out of 5 stars
By Heidi on Oct 11, 2023

Calming medicine really works!

We have a rescue dog who is particularly sensitive to loud sounds. After summer backyard renovation work was completed and the machinery had cleared, she would not go in the backyard without shaking and drooling. We got Vetquinol and 2 days after taking it twice daily, she started going outside without shaking - and is almost back to normal! We had almost given up hope but this has really helped level out her fears. We will wean her off but will keep this on hand for the next time her fears take over and paralyze her.

Rated 5 out of 5 stars
By Bigpuppymomma on Sep 26, 2023

Really helps

Our cat Jack was getting anxious causing him to go "out" of the litter box, This 75 mg version of the product was very helpful in letting Jack be his normal self, and he started going back to using his litter box almost right away.. still trying to figure out the source of the anxiety, but in the mean time it is really helping him. The pricing of the 200 count bottle was very helpful.. but the pricing for the big bottle of 450 mg for the big puppy who gets upset on occasions due to fireworks loving neighbors and etc... was ridiculously priced and I am still stuck ordering that one one 30 count bottle at a time... thankfully 7 small bottles have taken me through an entire year. Thank you for a very helpful product.

Rated 1 out of 5 stars
By Dawn on Sep 21, 2023

Cat won’t take it

My cat freaks out when company comes. Hides, doesn’t eat and gets comstipated. I need to calm him when company comes for a week.. No matter what food I put it in, he must have smelt it. Dry, wet, even tuna!! Walked away and cried for food. This med needs to be in tablet form so I can get it down his throat He takes tablets just fine. Very expensive and unable to use. Do not recommend for cats in this capsule form which you open to put on or in food..

Rated 5 out of 5 stars
By Rebecca on Nov 9, 2023

Cat LOVES this stuff

My cat loves this stuff. LOVES IT. He is a very nervous guy, and this does seem to help him relax a bit more. He will never be mellow, but he seems happier and more relaxed.

Rated 5 out of 5 stars
By Maurine on Oct 3, 2023

It really helps.

I have a couple fairly intense cats so am always looking for something to help with toe trims, doctor visits, car rides, etc. This stuff works but doesn't completely zombie them out like some prescription meds. I'll keep using it.

Rated 4 out of 5 stars
By LarryL on Jul 29, 2023

New purpose, waiting to see

I've used this product with success in the past when I had a cat with hyperthyroidism. In addition to his meds this helped keep him calm in general. Now, I have an older (13 years) boy who seems to be exhibiting signs of arthritis. So, in addition to other supplements specifically meant for easing arthritis pain/inflammation, I am just starting to give him this to keep him relaxed. It's only been a couple of days. He seems pretty calm but I'm not sure I can attribute it to Zyklene or not, yet. My gut says it does calm cats down in a gentle way...I don't like sedation.

Rated 5 out of 5 stars
By Cathy on Nov 29, 2023

The best

My cat, who is afraid of everything, gets a sprinkle on her wet food every nite. Calms her down alittlle.

Rated 1 out of 5 stars
By Ruben on Nov 9, 2023

for a flight

purchased to calm anxiety for my half chihuahua and shih-zu mix dog. It did not work to calm him for the flight we took.