Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats

By Vetoquinol
Rated 3.9202 out of 5 stars


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$33.99Chewy Price
$32.29Autoship Price
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About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 75 mg capsules that can be given by mouth, or opened and mixed with a meal.

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Nutritional Information

Feeding Instructions


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Top IngredientsActive Ingredients: Hydrolized Milk Protein (Bovine), Inactive Ingredients: FD&C blue #1 (capsule), Hypromellose (capsule)...Dried Hydrolysed Casein, Maltodextrin, Magnesium Stearate.Dried Hydrolysed Casein, Maltodextrin, Magnesium Stearate.Active Ingredients: Thiamine, L-Tryptophan, Chamomile Extract...Thiamine, L-Tryptophan, Hemp Seed Oil...
Breed SizeExtra Small Breeds, Small BreedsMedium Breeds, Large BreedsLarge Breeds, Giant BreedsExtra Small Breeds, Small Breeds, Medium Breeds...Extra Small Breeds, Small Breeds, Medium Breeds...
Health FeatureCalmingCalmingCalmingCalmingCalming
LifestagePuppy, Kitten, Adult, SeniorPuppy, Adult, SeniorPuppy, Adult, SeniorPuppy, Kitten, Adult, SeniorPuppy, Kitten, Adult, Senior
Food FormSupplementSupplementSupplementSupplementSupplement
Food FlavorUnflavoredUnflavoredUnflavoredUnflavored

Questions & Answers

29 Customer Questions

Can this be given long term for severe anxiety?
Answer by ChewyJan 04, 2018
This Supplement is intended for short term use. Use as recommended by your veterinarian.

I'm moving and am taking my 2 cats and 3 dogs with me.. would this help them for an 18 hour drive?
Answer by ChewySep 20, 2018
This is perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.

Are any of the ingredients made or obtained from China? Where is this manufactured?
Answer by ChewyNov 07, 2019
This product is sourced in Canada and manufactured in the USA.

Is this for dog depression??
Answer by ChewyOct 25, 2017
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs and cats safely and with no tranquilizing or sedating effects.

ReviewsWrite a Review

Rated 3.9202 out of 5 stars
351 Ratings
Would recommend to a friend

351 Customer Reviews

Rated 5 out of 5 stars
By Bigpuppymomma on Sep 26, 2023

Really helps

Our cat Jack was getting anxious causing him to go "out" of the litter box, This 75 mg version of the product was very helpful in letting Jack be his normal self, and he started going back to using his litter box almost right away.. still trying to figure out the source of the anxiety, but in the mean time it is really helping him. The pricing of the 200 count bottle was very helpful.. but the pricing for the big bottle of 450 mg for the big puppy who gets upset on occasions due to fireworks loving neighbors and etc... was ridiculously priced and I am still stuck ordering that one one 30 count bottle at a time... thankfully 7 small bottles have taken me through an entire year. Thank you for a very helpful product.

Rated 1 out of 5 stars
By Dawn on Sep 21, 2023

Cat won’t take it

My cat freaks out when company comes. Hides, doesn’t eat and gets comstipated. I need to calm him when company comes for a week.. No matter what food I put it in, he must have smelt it. Dry, wet, even tuna!! Walked away and cried for food. This med needs to be in tablet form so I can get it down his throat He takes tablets just fine. Very expensive and unable to use. Do not recommend for cats in this capsule form which you open to put on or in food..

Rated 4 out of 5 stars
By LarryL on Jul 29, 2023

New purpose, waiting to see

I've used this product with success in the past when I had a cat with hyperthyroidism. In addition to his meds this helped keep him calm in general. Now, I have an older (13 years) boy who seems to be exhibiting signs of arthritis. So, in addition to other supplements specifically meant for easing arthritis pain/inflammation, I am just starting to give him this to keep him relaxed. It's only been a couple of days. He seems pretty calm but I'm not sure I can attribute it to Zyklene or not, yet. My gut says it does calm cats down in a gentle way...I don't like sedation.

Rated 5 out of 5 stars
By rescuecats on Jun 27, 2023

Cat peeing outside box

We had a 7 month, petite, rescue kitty returned because she was eliminating outside the litter box (mostly peeing outside but also poo too). We took her to the vet to insure that there we no medical issues. We tried various litters, litter boxes, depths of litter, locations of boxes. Finally, we tried Zylkene. After just a few days, she seemed more relaxed. She now uses her box on a regular basis! She doesn't cover her poo but at least it is in the litterbox!!!!!!!!!!!! We open the capsule and scatter the Zylkene over 1/2 a Friskies lil'soups once a day. She also seems to be nicer to the other cats in the rescue. We will leave her on this for 2 months and then revisit adoption with full disclosure. If she has a second failure, we will just move her into "unadoptable" status and keep her in the sancuary.

Rated 4 out of 5 stars
By kat on Jun 27, 2023

It works...for some cats

I've used Zylkene on two separate occasions. The 1st time was with a 4YR old male, Herman who I introduced to my resident 14YR old male, Lazarus. It didn't seem to make much difference with Herman. thankfully they worked out their relationship on their own. The 2nd time - most recently - I have seen a dramatic difference in my new 9 month old male kitten, Chui to my current resident 5YR old male, Digit. Initially, Chui was a non-stop ball of energy who enjoyed ninja-attacking Digit at every opportunity, which he didn't appreciate. As soon as I mixed the contents of the capsule in Chui's food, he calmed down considerably. It only seems to last for about 4 hours. Given that he's still young, I'm hesitant to increase the dosage.

Rated 5 out of 5 stars
By Wendy on Aug 20, 2023

Great product

My pup has seizures and one of his triggers is stress. My recommendation from our trusted vet we ordered zylkene. Since using the product my pup is able to relax a little more and has decreased his number of seizures.

Rated 4 out of 5 stars
By Kim on Jul 11, 2023

Helps my kitty

My vet suggested this supplement when I asked for help with one of my cats who was bullying my other cat. He wasn’t helped by pheromones but I have noticed his bullying has decreased quite a bit, he is less fearful of strangers and more affectionate towards us. It took about 3 weeks to notice a change but I’m really happy they’re getting along better. I wish I’d known about xylene sooner!

Rated 1 out of 5 stars
By CB on Sep 9, 2023

Didn't do anything

These had no effect on my dog. But, giving it a star because the packaging was nice and the capsules were easy to open.

Rated 4 out of 5 stars
By Harriet on May 27, 2023

Amazing improvement

Remarkable change in less than 2 weeks. Using along with Adaptil collar and behavior mods. 5 star results except for capsule. Buried it in food but she dropped one and it stuck to her fur and turned it blue. I'm now opening and mixing it in the food. A tablet would be easier. Pricey for long term use but an amazing product.

Rated 5 out of 5 stars
By Kim on Jun 22, 2023

Zylkene works for my Dog

Zylkene was recommended by my vet for my small dogs nervous, extremely shy, behavior. It has worked wonders! My dog is not as nervous and the shyness is diminishing. She's a rescue so it's a journey! No side effects.