VETOQUINOL Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats, 30 count -

Vetoquinol Zylkene 75-mg Capsules Calming Supplement for Small Dogs & Cats

By Vetoquinol
Rated 3.9294 out of 5 stars

$33.99Chewy Price
$32.29Autoship Price
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About This Item


  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 75 mg capsules that can be given by mouth, or opened and mixed with a meal.

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Nutritional Information

Feeding Instructions


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Learn More About Vetoquinol From Our Team of Experts

Questions & Answers

28 Customer Questions

Can this be given long term for severe anxiety?
Answer by ChewyJan 04, 2018
This Supplement is intended for short term use. Use as recommended by your veterinarian.

I'm moving and am taking my 2 cats and 3 dogs with me.. would this help them for an 18 hour drive?
Answer by ChewySep 20, 2018
This is perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.

Are any of the ingredients made or obtained from China? Where is this manufactured?
Answer by ChewyNov 07, 2019
This product is sourced in Canada and manufactured in the USA.

Is this for dog depression??
Answer by ChewyOct 25, 2017
The non-drowsy formula uses alpha-casozepine, a natural ingredient found in cow’s milk, to help balance the stress reactions of dogs and cats safely and with no tranquilizing or sedating effects.

ReviewsWrite a Review

Rated 3.9294 out of 5 stars
340 Ratings
Would recommend to a friend

340 Customer Reviews

Rated 4 out of 5 stars
By Harriet on May 27, 2023

Amazing improvement

Remarkable change in less than 2 weeks. Using along with Adaptil collar and behavior mods. 5 star results except for capsule. Buried it in food but she dropped one and it stuck to her fur and turned it blue. I'm now opening and mixing it in the food. A tablet would be easier. Pricey for long term use but an amazing product.

Rated 5 out of 5 stars
By CareToBeChoosey on Apr 5, 2023

Finally found a calming supplement that works!

My 10 years old female cat started to have anxiety disorders 3 years ago. She started to spray every objects and all peripheral walls and doors of the house and she developed cystitis. I had thrown out my living room couch, loveseat and the big stuffed chair because of her relentless urine markings. Everything has to be covered with washable water proof bedding pads. This year I have to tear-out all my hardwood floors and carpets and put in tile floors throughout the house. My cat’s veterinarian has prescribed numerous calming treatments, supplements and prescription medications, but none was effective. Final someone told the veterinarian about this supplement, then the veterinarian called me and told me to try this before trying another psychoactive medication. I have given this once a day mixed in the Delectable/Lick-Able cat treat for 5 days now. It started to calm my cat after the 1st dose! She still do markings, but that has greatly reduced from 5x per day to 0 - 2x per day. Her cystitis seemed to be calming. I’m praying that she will continue to consume this supplement and that it will continue to work.

Rated 1 out of 5 stars
By Zylkene on May 4, 2023

Cats are lactose intolerant. caused problems

This gave all 3 of my cats diarrhea. I learned from a vet & rescue that I volunteered for that cats are lactose intolerant (this can be googled). I don’t know why I thought this would work. My poor babies were sick & We had such messes to clean up. This product should not be given to cats.

Rated 5 out of 5 stars
By Pippin on Apr 26, 2023


No medicine here, all natural made from milk. Dog always was calm. A bit sleepy if not sleeping when traveling on the plane. Never heard a word from her! Buy it you will not be disappointed!! Was recommend to us by our Swiss vet when we lived in Switzerland.

Rated 5 out of 5 stars
By CatMom68 on Mar 5, 2023

works like a charm!!

I relocated from Pennsylvania to Georgia with my cat. We were driving 13 hours. I gave her the recommended dose a half hour before we hit the road. She was up for the first half hour and slept most of the 13 hour drive, with the exception of the last hour. She was quiet all the time that she was awake. It kept her very calm. No side effects. I would highly recommend this for anyone considering using this product. She has to go to the vet this week and I’m going to use a smaller dosage for the car ride to the vet as well.

Rated 5 out of 5 stars
By Heather on May 4, 2023

Helped with new puppy

This product along with adaptil plug in has helped our new puppy acclimate to his new home and crate! Easy to put over his food and he eats it without an issue. Highly recommend!

Rated 2 out of 5 stars
By Dynah on Feb 17, 2023

Had opposite effects

I had high hopes for this. We have a sixteen year old miniature schnauzer who has entered the more advanced stages of dementia and as a result experiences anxiety at night. Unfortunately this supplement made him behave like he was on a stimulant. He raced around the house and ran into things, his eyesight is getting bad too, and was up all night. The second day we only gave him half the recommended dose, and the same thing happened. I wanted to avoid giving him drugs from the vet, but it looks like we will have to take that step.

Rated 5 out of 5 stars
By Dogma on Dec 22, 2022

Like flipping a switch

On a weekend I called Chewy and spoke with their Vet about behavior my formerly sweet Jack Russell had begun with his playmate canines. She recommended Zylkene,with a grain of skepticism I ordered that same day. After a week the nipping head butting over aggressive play destructive energy bursts even potty in the house diminished by 75%. Now he loves to learn sits long enough to take part in short training sessions even his play has calmed. I am so grateful for this product and the Vet at Chewy whose advice saved us expensive Vet visits.This is so worth a try Sam who at heart is a loving boy deserves to be happy as his playmates in the home when we feared at times not being able to keep him,once again Chewy delivers in the truest sense. Thanks all around for his product!

Rated 1 out of 5 stars
By Sandie on Mar 27, 2023

My review of vetoquinol

I had high hopes since I'm desperate with a cat that won't stop spraying. Have tried everything. This did nothing to help him. Glad it worked for some.

Rated 5 out of 5 stars
By Karol on Apr 1, 2023

highly recommend

works great. was about to put my cat on Prozac before finding this. It’s been two months with no urinating outside the litter box.