Zymox Hydrocortisone Free Dog & Cat Ear Infection Solution, 1.25-oz bottle

By Zymox
Rated 4.2778 out of 5 stars
$19.49Chewy Price
$25.99Chewy Price

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About This Item


  • Paw-fect for dogs and cats of all ages, this solution works to soothe ear infections, redness and inflammation.
  • Gentle, no-sting formula helps ease painful ear infections caused by germs, fungi and yeast.
  • This natural solution contains no medication or hydrocortisone—ideal for pets with sensitive skin.
  • No pre-cleaning of painful ears required—simply fill the ear canal and let the solution get to work.
  • ZYMOX's LP3 Enzyme System helps clear ear secretions and promotes healthy ears.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsBenzyl Alcohol, Deionized Water, Dextrose...Propylene Glycol, Glycerin, Benzyl Alcohol...Active Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Chlorhexidine Gluconate, Ketoconazole, Water...
Breed SizeSmall Breeds, Medium Breeds, Large BreedsSmall Breeds, Medium Breeds, Large Breeds
Health FeatureEar CareEar CareEar CareAnti-Fungal / Anti-Bacterial, Ear CareEar Care
LifestageAdultAdultAdultPuppy, Kitten, Adult, SeniorAdult

Questions & Answers

2 Customer Questions

Is this product safe for pregnant dogs?
Answer by ChewyAug 01, 2020
These ear drops are suitable to be used on any age dog, cat, exotic, as well as those that are pregnant or lactating.

Does this product leave an oily residue?
Answer by ChewyOct 08, 2019
This product should not leave behind any oily residue.

ReviewsWrite a Review

Rated 4.2778 out of 5 stars
18 Ratings
Would recommend to a friend

18 Customer Reviews

Rated 5 out of 5 stars
By CESARCC on Jul 16, 2022

Ear infection cleaner

This product cleaned my Maltese Shih Tzu ear infection. With in a few days her ear is much better

Rated 5 out of 5 stars
By JoAnna on Mar 6, 2022

Zymox worked

I used this for my 16 year old cat. She had a fungal infection in her ears. I used it for around 7-10 days and there was significant improvement in the first few days.I stopped using it because she scratched and had open wounds. I think it cleared the infection, if there was any left the Vetericyn wound care took care of it.

Rated 5 out of 5 stars
By CK on Apr 9, 2021

Keeps Ears Clean!

We moved to SETX and my dog's ear has been bothering him. I would clean it but it still seemed to bother him. I started to use this and it stopped the irritation - literally the next morning they weren't red anymore. At his yearly vet visit, the doc said his ears look great. Highly recommend!

Rated 5 out of 5 stars
By Mattress on Apr 11, 2021

Very effective

My poor baby has been suffering from multiple ear infections, veterinary recommends this product to ease discomfort. Helps clean gunk from ear

Rated 5 out of 5 stars
By Holly on Apr 12, 2021

Works great

It seems to be working on my cats ears that are infected. The ears have come to stand up straight, instead of being flat against their heads.

Rated 5 out of 5 stars
By LindaB on Aug 18, 2020

Amazing Zymox!

I learned about this product about three years ago when a new kitty entered my life. She has one ear that chronically gets dirty and itchy and waxy. Apparently it is caused by food allergies, no chicken or fish for her! And also hot, humid weather doesn't help and environmental allergies as well. I have been using Zymox, WITHOUT steroid. It works!!!! Cleans her ear, calms the itch. I hear of too many scary stories about steroids, so I stay clear of it. Not necessary in my case

Rated 1 out of 5 stars
By magic on Aug 16, 2020
Top 1000 Contibutor

Used for king with build up of wax

Used several time but got no results. I used for 2 week then stopped then tried it again. I have an outside kitty who came to me with really bad wax build up I was thinking it's a yeast infection

Rated 5 out of 5 stars
By BRianna on Jun 25, 2020

Severe ear allergies

We have a Lab pit mix and he has horrible allergies, his ear gets super inflamed, red, painful to the touch, we were referred to this med and it made a huge difference.

Rated 5 out of 5 stars
By Bebe on Feb 15, 2020

Excellent ear solution!

I use both this and the regular cortisone formula, depending on the severity of irritation my cat is experiencing; It's best to minimize steroid use, especially when it can be ingested. But this Ear Solution has solved ear problems just as they start and keeps them at bay - even when I had exhausted veterinarian prescriptions for a year and a half. I am so grateful for this product! I have found that if I warm the bottle up in a cup of hot water from the tap with a washcloth holding it submerged (DO NOT MICROWAVE THE BOTTLE) that it lessens the discomfort my cat experiences when I put the drops in. Even room temperature is very cold and icky feeling in the ears - I know from my own personal experience with ear drops - and the cat doesn't cry out anymore. Very glad to have this!

Rated 1 out of 5 stars
By Ella on Jan 14, 2020

Made it worse

It did not work for my cat made it worse. Should have got what I did the last time the one with Hydrocortisone in it. Would not recommend it cause I don’t know your cat .It might work or it might work.