Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8237 out of 5 stars


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$55.79Chewy Price
$73.99Chewy Price
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FREE 1-3 day delivery

About This Item


  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

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About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Propylene Glycol, Glycerin, Benzyl Alcohol...Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Benzyl Alcohol, Beta-Glucanase, Cellulase...
Health FeatureEar CareEar CareEar CareEar CareEar Care
Breed SizeSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

14 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Does this contain a drying agent?
Answer by ChewyApr 18, 2019
Zymox does not contain any drying agents.

I was putting another ear infection medicine on my dog. When I get this one do I clean my dogs ears before putting the zymox or do I just put it ?
Answer by ChewyApr 30, 2021
Cleaning the ear prior to use of this product is not recommended

Is this the consistency of water or a little thicker?
Answer by ChewyJan 07, 2019
These drops will have a consistency similar to water.

ReviewsWrite a Review

Rated 4.8237 out of 5 stars
2451 Ratings
Would recommend to a friend

2433 Customer Reviews

Rated 5 out of 5 stars
By Linda on Nov 21, 2023

Great to prevent and treat ear infections

My 2 year old Golden Retriever has been getting chronic ear infections in her right ear since she was a puppy. It usually presents as a red ear and ear flap with a heavy, black, coffee grind looking substance in her ear. When I took her to the vet, he gave me antibiotic pills, a prescription ear drop medication that fights bacteria and yeast, and Zymox. He told me to use the prescribed medications first, then Zymox weekly. Within a week or two the ear infection was back. I was very frustrated and complained to the vet. He told me I should use the Zymox daily for a week or two until it clears up, then use weekly. I really didn't think that an OTC product would cure my dog's ear infection, but, IT DID!!!! Within two days, the black coffee grind substance decreased immensely. After about a week, her ears looked great! I now use it weekly and rarely have a problem. If she does have a break-out, it's usually because we forgot to give it to her for a week or two. However, if that happens, I just start giving it to her daily again for a bit and she is good as new. This stuff is really great! It is such a relief to have a product that works that I don't have to go to the vet for. I highly recommend this!

Rated 5 out of 5 stars
By sealess on Nov 18, 2023

Been using it for years

This stuff was suggested to me at a park. My Mastiff had chronic ear infection for years. Went to vet regularly to have painful ear flushes and then pay aton of money for flushes and drops. The infection always return Ed. I tried Zymox Otic and amazingly it cleared it up within a week and never returned. I put 3 drops in each ear once a month just to be sure. It improved his quality of life exponentialy. He was 16 when he passed ..he had pain free clean ears. Thank You so much for this product. Not only has it saved me a fortune more importantly has been a mandatory product for the health of all my pups and cats.

Rated 5 out of 5 stars
By Animallovingmama on Oct 29, 2023

Worth every penny

My hound is super prone to infections from yeast, and bacteria building up that easily finds its way into his big floppy ears. He's consistently gotten ear infections every few months since he was a year old, and he's almost 5 now, so this has been an ongoing battle. I love this product! It treats the infections but also quickly relieves his discomfort from them! I don't know about other folks, but going into the vet every couple of months for an exam just to get the medication that I already know I need for him is ridiculous and costly, so when I read the reviews from people complaining about the price of this product it just seems silly to me, because it's so much more cost effective than routine vet appts are, and it's easily obtained! I will continue using this product as long as it's necessary.

Rated 5 out of 5 stars
By Kimeta on Oct 28, 2023

Highly recommend for ear issues!

My cat had heavy ear irritation. It didn't seem like ear mites but his ears looked pretty waxy and inflamed. He was scratching like zombies were coming. I suffer from a lot of ear wax too so I just figured it runs in the family. I followed the instructions using once a day for 7 days. By day 5, he was itching less and his ears were returning to his normal pink color. He hated those 7 days and would run from me when he saw me coming with the bottle and cotton pad lol...but he's better now. I can sense his gratitude by his slow blinks when I compliment how healthy his ears look. I would definitely purchase again if needed.

Rated 5 out of 5 stars
By Ed on Nov 7, 2023


After over 50 years of German Shepards, decided I was too old and not able to properly care for big dog BUT never heard of Anatolian Shepard, I had to have it at my age of 72. He is in excess of 160 pounds and sometimes will get an ear infection and THIS product works perfectly if you follow the directions.

Rated 5 out of 5 stars
By Cori on Nov 12, 2023


This stuff has worked wonders for my poor dog who tends to get irritated ears. It’s easy to use and you see results quickly. Her ears aren’t hot anymore and she’s not going crazy trying to scratch them. Definitely a bit pricy, but it’s cheaper than a vet visit for the same thing. Well worth it!

Rated 5 out of 5 stars
By Cathryn on Nov 12, 2023

Recommended by my vet

After taking my dog to the vet for an ear infection, she specifically recommended I keep this product on hand for future use. I have and use it at the first sign of a potential infection. None have ever developed after I began using this. I will always keep it on hand.

Rated 5 out of 5 stars
By banjoboy on Oct 1, 2023

Great Solution for Ear Infections

My spaniel gets ear infections every 3 months or so - I was tired of waiting for a prescription from my vet, and found this on chewy due to the good reviews. It has helped so much! We use it consistently for 4-5 days in a row, and the smell was gone by day 3. I could tell my dogs pain went down too because he wouldn’t yip when he would scratch his ears. I am so glad I found this solution and definitely recommend!!

Rated 5 out of 5 stars
By Leanne on Nov 5, 2023

Great for ongoing ear problems

My sharpie has narrow ear canals and the surgery is so expensive to widen them so she is always having ear problems with infections and yeast build up. This medication helps her alot and keeps it under control with regular use.

Rated 5 out of 5 stars
By Gab on Nov 15, 2023


My dog is a basset hound so we are immune to ear infections . Within day 3 of this the head shaking has completely stopped . I am so impressed and so glad I can use them for future ear issues.