ZYMOX Otic Dog & Cat Ear Infection Treatment with Hydrocortisone, 1.25-oz bottle - Chewy.com

Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8251 out of 5 stars

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$23.79Chewy Price
$31.99Chewy Price

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About This Item


  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Questions & Answers

56 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.8251 out of 5 stars
2322 Reviews
Would recommend to a friend

2322 Customer Reviews

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Rated 5 out of 5 stars
By nancyerric2019 on Mar 19, 2023

Highly recommended!

Our dog's ear was red, smelly, and infected. We were concerned about going to a vet and having to pay hundreds of dollars to take care of it. Luckily, my husband found this product and read the reviews. So we took a risk. We're so glad we did because we used it in her ears for about 3 straight days and then it cleared completely! Highly recommend for any pet parents whose dog might have an ear problem!

Rated 5 out of 5 stars
By jmg493 on Mar 8, 2023

Works Great for my Cat & Dog

I initially purchased for my dog when he was a puppy, but now we get him groomed regularly. It worked great at the time, but I recently needed to start using it for our new kitten that has an issue with excessive wax buildup. Using it as directed has shown the best results and she’s even starting to look forward to the ear cleanings. Would highly recommend in combination with using cotton swabs to wipe out any excess wax prior to letting them shake.

Rated 4 out of 5 stars
By Roxie on Mar 14, 2023

Great product

I have bought this before and liked it and have never had a problem. Unfortunately the last time I ordered it the nozzle popped off the first use and over half the bottle went all over my cat. I then had to order another bottle. Not sure what happened but do not like items that cause me to spend more money.

Rated 1 out of 5 stars
By reddancer on Feb 16, 2023

Seems to burn

My cat has ongoing ear issues so I wanted to try something otc and cheaper than the Rx Tresederm that the vet prescribes. Well I tried this multiple times and my cat reacts like these drops are hurting him. I don’t know if they sting or burn or what but he flips out and his ears seem to be MORE irritated afterwards. He doesn’t react this way to the Tresederm and his ears seem immediately soothed by that so I guess we have to stick with it. Zymox is going in the trash.

Rated 5 out of 5 stars
By Pete on Mar 13, 2023

Corgi/Feist Constant Dry Ears

I love this solution. My corgi battles dryness within the ear weekly. As soon as it is spotted, I will apply some of the Zymox ointment and all the dry skin or redness goes away. Any leftover dry skin is easily removed with a wipe and his ear health is improved right away.

Rated 5 out of 5 stars
By Dieselsearmedsreview on Feb 2, 2023

Amazing product definitely recommend!!

This product helped my pit faster than any vet medication has. I was taking him to the vet at least 2x every other month due to ear infections and the meds they gave always took forever and a half to actually kick the infection. When I put this product in he stopped itching almost immediately and the head shaking went away. And after a few days the infection was gone as he stopped showing signs of distress. Definitely try this product especially if you got furbabies with ear infections!

Rated 5 out of 5 stars
By Bobo on Mar 12, 2023

Glad I purchased this!

This stuff works! My older kitty managed up a pretty bad ear infection of some sort. I cleaned them out the day before with baby oil and now I’m using this daily. Her ears are less red and her hearing is coming back. Definitely recommend!

Rated 5 out of 5 stars
By Sally on Jan 27, 2023

Great Product

We purchased this product based on internet reviews in order to help our recently adopted GS female get some relief from her dirty and possibly infected ears. We used this product every day for 7 days, cleaning out both ears. Great news that things have cleared up significantly. We are very happy with the results and would recommend this product. We will now be using the ZYMOX ear cleaner once or twice a week in order to maintain regular ear cleaning. Thanks!

Rated 5 out of 5 stars
By Ollie on Feb 8, 2023

So far so good

Our Ollie has gotten a yeast infection in his ear after grooming 2 x now. The vet drops were 65 dollars and I decided to try this this last time. It worked. 4 drops in ear for 7 days and his ear is good. It comes out easy, and he had relief by day 3. Glad we tried and have on hand for when it may not be required to go to his dr everytime.

Rated 5 out of 5 stars
By mail on Mar 12, 2023

Helped an ear infection.

It snows where we live and I believe that my dog had gotten an ear infection from snow going into her ear. It saved me a Vet visit. Worked fine after 7 days of use.