Zymox Otic Dog & Cat Ear Infection Treatment with Hydrocortisone

By Zymox
Rated 4.8248 out of 5 stars


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About This Item


  • Effectively treats acute and chronic otitis externa due to bacterial, fungal and yeast infections. This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Contains three active enzymes that have shown to be antibacterial, antifungal and antiviral.
  • Hydrocortisone helps to provide relief from itching and inflammation.
  • Three-point enzyme system destroys antibiotic resistant microorganisms, including Staphylococcus.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsActive Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Propylene Glycol, Glycerin, Benzyl Alcohol...Benzyl Alcohol, Beta-Glucanase, Cellulase...Water, Propylene Glycol, Isopropanol...
Health FeatureEar CareEar CareEar CareEar CareEar Care

Questions & Answers

57 Customer Questions

Is this safe for cats as well ?
Answer by SuzannaMay 14, 2021

Will the 1.25 ounce bottle be enough to treat 1 dog, both ears?
Answer by ChewyOct 08, 2017
The 1.25 ounce bottle will provide more than 2 weeks worth of daily maintenance to both ears.

how long do you massage the base of your pet's ear and keep the liquid in the ear canal?
Answer by ChewyAug 24, 2018
Massage the base of your pet's ear until the treatment has coated the infected area.

Is this safe if ingested? I have three dogs that like to lick/clean each others ears and want to ensure this is safe.
Answer by ChewyOct 02, 2018
Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use.

ReviewsWrite a Review

Rated 4.8248 out of 5 stars
2409 Ratings
Would recommend to a friend

2404 Customer Reviews

Rated 5 out of 5 stars
By bharbin on Sep 23, 2023

Expensive, but works

My pit is prone to ear infections and on allergy meds, but this helps when I notice some excess build up between cleanings. She does not like her ears messed with so I don't clean her ears as often as I should, and she's not a fan of the gel, but it does get results. Doesn't cure every ear infection, but it helps decrease our number of annual vet visits.

Rated 5 out of 5 stars
By Dogfather on Sep 18, 2023

A reliable option

While Zymox is relatively pricy, it consistently works. It is far less costly than trips to the vet. Apply after wiping the ear canal with a cotton ball. Several drops are enough if you follow that with gentle massage to encourage the medicine into the deeper parts of 5he canal.

Rated 5 out of 5 stars
By Tyler on Aug 24, 2023

This medicine deserves 100 stars

Just want to say I never write reviews. But this medicine worked immediately & totally deserves 5 stars. My dog was scratching at his ear for a few days. So I knew I needed to try something or take him to the vet. I purchased this and he stopped scratching immediately. I can’t thank this medicine enough hope it helps your pet as well.

Rated 5 out of 5 stars
By Mrda22 on Sep 25, 2023

Great product

My puppy had a red ear and was scratching her ears. Bought this and followed all instructions and after 3 days she had no redness and after 7 she was totally fine. Saved me a vet visit and big bill .

Rated 5 out of 5 stars
By CAROL on Sep 16, 2023

wonderful medicine

my dog had a very bad earache and i was not able to get to my vet i ordered Zymax otic and within three days knew i was on the right track my dog is now infection free and i saved two hundred dollars a wonderful product

Rated 5 out of 5 stars
By April on Aug 21, 2023

I can't say enough great things about this product its is like a mircle in a bottle it worked so well and fast for my pugs ear I spent so much money at the vet for ear infection and thier medicine didn't work as well as this really amazing stuff I am so happy I found it thank you chewy

Rated 5 out of 5 stars
By KelAndAlMom on Jul 10, 2023

Exactly what we needed

My cat Kelci has, for some reason, the gunkiest ears on Earth. No matter how many times we go to the vet for new cleaner recommendations or wipes or even prescriptions, she ends up with itchy ears a few days later full of grossness. We used this Zymox for a week, following the instructions, and her ear itch has gone down fantastically! We’ll wait to see whether that changes later, but her ears genuinely look cleaner and are less itchy a week later. Only one issue, and it’s not even that much of an issue - it’s very oily, and Kelci ended up with a light oily sheen on her little head for a few days. Otherwise, no complaints!

Rated 5 out of 5 stars
By Maggie on Aug 2, 2023

Great stuff

I had been dealing with my dogs ear problem for months. Flush8ng it, using expensive drops from the vet, and it would come right back (if it ever went completely away). A week of treating with this and it’s just about gone. Her was shaking his head constantly and crying when you touched it. So much better and even the funky smell has abated. Definitely worth the price.

Rated 5 out of 5 stars
By ProfessorMoony on Aug 12, 2023

Worked Miracles

I bought this for my dog as kinda of a last resort before going to the vet again. My dog isn’t even a year and struggles with constant ear problems/infections. I decided to give this a shot… his ears are no longer red (even after just 3 days), no more constant scratching, and just overall seems more content

Rated 5 out of 5 stars
By Desnialop on Jul 21, 2023


My poor baby had a terrible ear infection with a lot of scratching, shaking and gross stuff inside and I just didn’t have the money for a vet visit. I decided to look online for any remedies and saw so many positive reviews so I put my hopes and prayers into this product. Her ears felt and looked better within 24 hours!!! I kept applying for 14 days to be extra sure the infection resolved completely!