ZYMOX Otic Dog & Cat Ear Infection Treatment without Hydrocortisone, 4-oz bottle - Chewy.com

Zymox Otic Dog & Cat Ear Infection Treatment without Hydrocortisone

By Zymox
Rated 4.5574 out of 5 stars

$47.49Chewy Price
$61.99Chewy Price

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About This Item


  • Effective treats acute and chronic inflammation of the external ear in dogs and cats caused by bacterial, viral and yeast infections.
  • Contains three bio-active enzymes that have been tested to be antibacterial, antifungal and antiviral.
  • Perfect for multi-pet households or long-term maintenance.
  • This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Made in the USA.

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Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsNatural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.Active Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Benzyl Alcohol, Beta-Glucanase, Cellulase...Witch Hazel, Deionized Water, Glycerine...
Health FeatureEar CareEar CareEar CareEar CareEar Care

Questions & Answers

16 Customer Questions

Hi, I was just wondering if this will cure a dogs ear infection, and is it better to buy with or without hydrocortisone?
Answer by ChewyMay 30, 2018
This treatment is for acute and chronic inflammation of the external ear in dogs and cats caused by bacterial, viral and yeast infections. The Zymox Otic Pet Ear Treatment with Hydrocortisone, has added hydrocortisone which helps to provide relief from itching and inflammation.

Can this be used for other animals like rabbits ???
Answer by ChewyMay 30, 2019
ZYMOX® is formulated without antibiotics, harsh chemicals and is non-toxic. It is ideal for dogs, cats and can be used on furry pets and farm friends of all ages.

Do I need a prescription for this?
Answer by ChewyDec 17, 2018
This does not require a prescription.

Can zymox be used for ear wax buildup
Answer by ChewyAug 02, 2021
The powerful enzymatic action of the patented LP3 Enzyme System naturally cleans, disinfects and removes ear exudate while destroying even the most resistant microbes.

ReviewsWrite a Review

Rated 4.5574 out of 5 stars
244 Reviews
Would recommend to a friend

244 Customer Reviews

Filter by reviews that mention

Rated 2 out of 5 stars
By Tony on Jan 2, 2023

Was HOPING this would work

I did the 14 day on my senior cat as instructed due to chronic yeast, bacterial ear issues for 10 months now. She is allergic to steroids so she cannot use the meds from the vets. This seems like it worked then suddenly the issue came back. Going to try the Zymox Gold label as a final Zymox product.

Rated 5 out of 5 stars
By Betsy on Nov 6, 2022

Shepherds & ears.

I have 3 shepherds that occasionally get ear issues. I can tell when a bout is coming on because they shake their head often. A 7 day course of Zymox always takes care if the problem. I keep a bottle on hand so I can tackle the problem right away. It is good stuff, & saves me a vet visit.

Rated 5 out of 5 stars
By Cheeky on Dec 22, 2022

Works wonders!!

This product cleared my dogs ear infection and cleaned up his ears with just 3 doses!! Chewy is an Awesome company to deal with!

Rated 5 out of 5 stars
By Shari on Nov 17, 2022

Zymox optic

Excellent preventive..I use once every 2 weeks and have not had any ear issues with my English lab.

Rated 5 out of 5 stars
By Pam1319 on Jan 21, 2023

Great product

Stopped itching almost immediately. Would recommend

Rated 2 out of 5 stars
By Henry on Sep 16, 2022

Be careful

I used this product on my Shepard. It made his ears worse. His eyes swelled up and became Ill. He's better since I stopped using it but I need. Recommendation for a good ear cleaner.

Rated 5 out of 5 stars
By Edith on Nov 30, 2022

Zymox Otic

Works great I use this regularly for my cats ears

Rated 5 out of 5 stars
By Ravenn on Jun 17, 2022

Best ear treatment ever

I've used Zymox Otic previously, and found it just as effective this time. It is easy to use, doesn't seem to cause discomfort, and most importantly, works very well and very quickly.

Rated 5 out of 5 stars
By EquiDobe on Jul 28, 2022

Zymox Otic - Excellent Product

Zymox is an excellent product. Cleaned ears and took care of slight irritation in a few days.

Rated 5 out of 5 stars
By Redsstress on May 3, 2022

clean ears!

I am thrilled with this treatment! I followed the directions on the bottle and I could tell it was working after 3 days. After using the prescribed 14 days my dogs ear is clean and she is back to normal! Great purchase!