Zymox Otic Dog & Cat Ear Infection Treatment without Hydrocortisone

By Zymox
Rated 4.6234 out of 5 stars
Slide 1 of 11
Zymox Otic Dog & Cat Ear Infection Treatment without Hydrocortisone, 8-oz bottle slide 1 of 11
Slide 1 of 11
Zymox Otic Dog & Cat Ear Infection Treatment without Hydrocortisone, 8-oz bottle slide 1 of 11

$82.49Chewy Price
$108.99Chewy Price
$78.37Autoship Price
Autoship (Save an extra 5%)
Choose Autoship at checkout for regular deliveries.

Why Autoship?

  • FREE access to chat with licensed vets 7 days a week.
  • Save 5% on all future Autoship orders.
  • No fees, no commitments - cancel Autoship anytime.

In Stock
FREE 1-3 day shipping

Frequently Bought Together

This Item - Zymox Otic Dog & Cat Ear Infection Treatment without Hydrocortisone, 8-oz bottle
Rated 4.6234 out of 5 stars
$82.49Chewy Price
Pet MD Aloe Vera & Eucalyptus Dog Ear Wipes, 100 count
Rated 4.4681 out of 5 stars
$13.99Chewy Price
Zymox Enzymatic Dog & Cat Shampoo, 1-gal bottle
Rated 4.6452 out of 5 stars
$85.79Chewy Price
Total Price: $0.00

About This Item

  • Effective treats acute and chronic inflammation of the external ear in dogs and cats caused by bacterial, viral and yeast infections.
  • Contains three bio-active enzymes that have been tested to be antibacterial, antifungal and antiviral.
  • Perfect for multi-pet households or long-term maintenance.
  • This liquid solution acts as both a cleaner and a treatment, in just one easy application daily.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

Compare Similar Items

Customer Rating
Rated 4.6234 out of 5 stars
Rated 4.8553 out of 5 stars
Rated 4.5 out of 5 stars
Rated 5 out of 5 stars
Rated 5 out of 5 stars
$82.49Chewy Price
$99.99Chewy Price
$55.13Chewy Price
$49.99Chewy Price
$55.38Chewy Price
$78.37Chewy Price
$94.99Chewy Price
$47.49Chewy Price
$52.61Chewy Price
Top IngredientsNatural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.Active Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...N/AN/AWater, Propylene Glycol, Isopropanol...
Breed SizeN/AN/ASmall Breeds, Medium Breeds, Large BreedsN/AN/A
Health FeatureEar CareEar CareEar CareEar CareEar Care
Packaging TypeN/AN/AN/AN/A

Questions & Answers

18 Customer Questions

Hi, I was just wondering if this will cure a dogs ear infection, and is it better to buy with or without hydrocortisone?
Answer by ChewyMay 30, 2018
This treatment is for acute and chronic inflammation of the external ear in dogs and cats caused by bacterial, viral and yeast infections. The Zymox Otic Pet Ear Treatment with Hydrocortisone, has added hydrocortisone which helps to provide relief from itching and inflammation.

I am looking for something to help my shepherds swimmer ear. Would this help?
Answer by ChewyJun 26, 2017
This product aids in the treatment of Otitis Externa (swimmer's ear).

Can this be used for other animals like rabbits ???
Answer by ChewyMay 30, 2019
ZYMOX® is formulated without antibiotics, harsh chemicals and is non-toxic. It is ideal for dogs, cats and can be used on furry pets and farm friends of all ages.

Do I need a prescription for this?
Answer by ChewyDec 17, 2018
This does not require a prescription.

ReviewsWrite a Review

Rated 4.6234 out of 5 stars
231 Reviews
Would recommend to a friend

231 Customer Reviews

Rated 5 out of 5 stars
By Ravenn on Jun 17, 2022

Best ear treatment ever

I've used Zymox Otic previously, and found it just as effective this time. It is easy to use, doesn't seem to cause discomfort, and most importantly, works very well and very quickly.

Rated 5 out of 5 stars
By Redsstress on May 3, 2022

clean ears!

I am thrilled with this treatment! I followed the directions on the bottle and I could tell it was working after 3 days. After using the prescribed 14 days my dogs ear is clean and she is back to normal! Great purchase!

Rated 5 out of 5 stars
By Morado on Apr 9, 2022

Just right!

I use this ear treatment on one of my dogs because she has allergies. The veterinarian said that's what it was. So this is affordable and efficient. It really works. Her itching stops when I treat my dog with it. Is used as needed.

Rated 4 out of 5 stars
By 2Shepherds on Dec 22, 2021
Top 100 Contributor

Works great!

First time ordering the Zymox Otic without hydrocortisone, and it works just as well. No odor to this product like some other brands have, and no mess. Use this on both our cats and our Shepherd, and it does the trick. Highly recommend this product, and Zymox products in general.

Rated 4 out of 5 stars
By Anna on Oct 7, 2021

Awesome so far!

This stuff has saved my life! My beagle is super prone to yeast infections in his ear and the meds that the vet gives him never seem to cut it- they always come back. Rather than spending another $150 at the vet for treatment, I decided to give this a try. I've been using it for about a week and a half and the difference is amazing. He is scratching way less and the redness and brown gunk have gone down a lot. He doesn't like to have the bottle squirted directly in his ear, so I do have to put it on my finger and rub it in but it seems to be working well! I'm only giving it 4 stars at the moment because the infection is not totally healed, but I'm very hopeful!

Rated 5 out of 5 stars
By TiasMom on Dec 20, 2021

Excellent! Have recommended.

Over the years this has solved all of our pets' ear problems. We have recommended it to friends and they all love it too!

Rated 3 out of 5 stars
By Pheona2000 on Dec 28, 2021

Overrated no change

Saw no improvement in ear. Using trizultra keto. Seeing improvement.

Rated 5 out of 5 stars
By Cassondra on Jul 21, 2021
Top 250 Contributor

Super Impressed

My Lab suffers from horrid ear infections in one ear. It is so bad that she is at the vet at least twice a month. Her vet suggested Zymox as an in-between. I was shocked at how well these work and how quickly. I opted to not get the hydrocortisone in case it interfered with her current medication. She went from miserable and having extremely red and sore ears to her happy self in 2 days!

Rated 5 out of 5 stars
By Beaglemom on Dec 11, 2021

Good product

My beagle has chronic yeast infections in his ears and this seems to help

Rated 5 out of 5 stars
By Catz on Aug 25, 2021

Cat with chronic ear problem

I have a cat with chronic ear infections. She was constantly scratching. There was dark brown stuff in her ears. Ear cleaner did not help. I tried Zymox for a week. It worked! No more scratching.