ZYMOX Plus Advanced Formula Otic Dog & Cat Ear Infection Solution, 1.25-oz bottle - Chewy.com

Zymox Plus Advanced Formula Otic Dog & Cat Ear Infection Solution, 1.25-oz bottle

By Zymox
Rated 4.5946 out of 5 stars
$29.99Chewy Price
$39.99Chewy Price
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About This Item

  • Naturally occurring enzymes are highly effective against bacterial, fungal and yeast ear infections. Great alternative to antibiotics and the non-toxic solution won’t irritate a pet’s sensitive or irritated skin. Safe enough for nursing/lactating pets and sensitive exotics.
  • Proven antimicrobial LP3 Enzyme System inhibits, splits and destroys the offending organisms while leaving healthy cells alone.
  • Four additional biofilm-reducing enzymes destroy the hard-to-penetrate biofilm slime layer that obscures the microbe.
  • Ideal for cases of repeated infections or infections that won’t resolve, and bacteria will never develop a resistance to the enzymes.
  • Made in the USA.
Play Video: Learn More About Zymox From Our Team of Experts
Learn More About Zymox From Our Team of Experts

About ZYMOX Enzymes for Healthy Ears and Skin

Antimicrobial and Antifungal Care

ZYMOX empowers pet parents with patented formulations of natural enzymes to help treat chronic infections in dogs, cats and horses. Their products are formulated to be safe to use on any age pet. ZYMOX packs a potent antimicrobial punch that targets the source of infections—bacteria and fungus(including yeast) to provide therapeutic relief, care, protection and prevention, without any antibiotics or harsh chemicals. Proudly made in the USA and endorsed by TICA (The International Cat Association).

Committed to Healthy Ears, Skin and Coat, and Smiles

To ensure overall health from snout to tail on all four-legged pals, Zymox has developed products that are specially formulated for all the areas that commonly need infection relief, like the ears, teeth and gums, and skin and coat.

Ear Care Solutions

Effective, non-toxic solutions with special enzymes and mild cleansers to keep ears clean and fresh, and combat microbes that can cause ear infections.

Oral Care Solutions

Brushless solutions with unique enzymes to dissolve plaque and prevent its buildup, boost natural "good bacteria," and protect against gum disease to keep kitty and doggy smiles healthy.

Skin and Coat Health

Topical sprays and shampoos for dogs, cats and horses that form a powerful protective barrier against minor skin inflammations from bacteria and fungi, while cleaning and conditioning the coat—with some formulas utilizing hydrocortisone.

100% Safe, Gentle and Easy

Because Zymox formulas are made with 100% naturally derived enzymes from dairy, they are safe for anytime use, both for immediate soothing relief and to prevent infections. The powerful enzymes work to eliminate problem single-celled organisms such as bacteria, fungi and yeast, while leaving healthy cells untouched. This means no irritations for your pal!

Enzyme-Based and Antibiotic-Free

Zymox products use a patented, gentle formulation that combines three potent, naturally occurring enzymes—lactoperoxidase, lysozyme and lactoferrin—that are sourced from milk products. These enzymes are proven to work together to eliminate the source of infection on your pet, without any toxins or antibiotics that can irritate or cause antibiotic resistance.


Zymox was founded in 1998 by Pamela Bosco, who sought to change the way that people treated and managed ear, oral and skin infections with a safer alternative to antibiotics. Enlisting the help of her brother—a scientist that developed the enzyme technology in Biotene—Bosco formulated a powerful enzyme-based solution to help treat infections in dogs, cats and horses with no toxins, chemicals or antibiotics. Committed to keeping all four-legged pals healthy, they offer USA-made and sourced products to treat, soothe and protect against bacterial and fungal infections gently and 100% naturally.

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Top IngredientsBenzyl Alcohol, Beta-Glucanase, Cellulase...Active Ingredient: Hydrocortisone 1.0%., Inactive Ingredients: Benzyl Alcohol, Bet-Glucanase...Benzyl Alcohol, Deionized Water, Dextrose...Active Ingredients: Hydrocortisone 1%., Inactive Ingredients: Benzyl Alcohol, Dextrose...Natural Enzymes, Lysozyme, Lactoferrin, Lactoperoxidase.
Health FeatureEar CareEar CareEar CareEar CareEar Care
Breed SizeSmall Breeds, Medium Breeds, Large Breeds

Questions & Answers

10 Customer Questions

Will this help get rid of possible mites in ears?
Answer by ChewyNov 01, 2017
This product is highly effective against bacterial, fungal and yeast ear infections so it’s an excellent alternative to antibiotics, not ear mites.

Does this contain hydrocortisone?
Answer by ChewyAug 31, 2017
This solution does not contain Hydrocortisone.

Can you use this on a pregnant dog
Answer by ChewyNov 13, 2017
It has a hydrocortisone free formulation that is safe for pregnant or lactating females, and small mammals.

What os the "active" ingredient in this product?
Answer by ChewyMar 04, 2020
This solution contains an antimicrobial LP3 Enzyme System with four biofilm-reducing enzymes

ReviewsWrite a Review

Rated 4.5946 out of 5 stars
74 Reviews
Would recommend to a friend

74 Customer Reviews

Rated 5 out of 5 stars
By Drea on Sep 21, 2022

Best ever!

I have a pregnant girl who developed a yeast infection in her ears. We went to the vet and they just gave a ear flush. Did nothing. Ordered this and started using it. By day 7 I had my happy girl back with happy ears. This will stay in the doggie med cabinet for sure!!

Rated 5 out of 5 stars
By Dogbabe on Mar 9, 2022

Saving Grace, thanks for making/ carrying this brand!!!

Finally a product that works for ear mites. I tried quite a few and this was by far a huge improvement after finishing a bottle, and I already ordered another to keep on hand- so make sure to follow directions... do not use any other ear washes while administering this.

Rated 5 out of 5 stars
By SkeetsMomma on Nov 1, 2021

Amazing Medicine!!!

My Bulldog Staffy mix has a chronic yeast infection problem in his ears! To the point he scratches his ears raw and cried it’s excruciating and heartbreaking i had to find some relief for him This medication is a life saver 1 week of treatment and his ears are normal again HIGHLY RECOMMEND!!!

Rated 3 out of 5 stars
By DRenda on Oct 13, 2021

Some help...

I gave this product 3 stars because it did help with the cleaning of the sticky stinky drainage, inflammation and swelling. But it didn't help with the infection.

Rated 4 out of 5 stars
By Annabelle on Jun 26, 2021

Mostly works

I had some "regular" formula that I had used for my first dog and it worked great. I bought this advanced formula for my rescue dog, who had been scratching at her ears for days and they were super dirty. I had cleaned them multiple times and they kept getting dirty again. I suspect that the puppy mill she came from did absolutely nothing to make sure she stayed healthy. This formula worked, for the most part. It alleviated the itchiness and gave some relief to my dog. She still had itchy ears and she will see a vet about it. I think she has something a bit more intense that this cannot handle.

Rated 5 out of 5 stars
By EarMeds on Aug 16, 2021

finally some relief!

I've tried a variety of ear meds on my GSD. I am keeping my fingers crossed but so far this has worked far better than anything else I have tried. She hates going to the vet, really hoping this does the job

Rated 5 out of 5 stars
By Kelly on Jul 24, 2021

Amazing Timing!

First time using this site, and I absolutely love it. I had my product the very next day. So far the product is working great. But I will update if they allow me.

Rated 1 out of 5 stars
By Cejota on Oct 9, 2021

It does not work

It did not work for my cat and I do not recommend it at all

Rated 2 out of 5 stars
By Lexi on Apr 17, 2021

Didn't work

I bought this since it didn't have the hydrocortisone in it and thought I'd use one drop per day as a preventative in my Cockapoos ears. After a week of usage, he still got an ear infection. I will go back to using our other Zymox formula.

Rated 5 out of 5 stars
By Jacksteeth on May 30, 2021

Ear magic!!

I put a little on a q tip everyday in my dogs ears and it keeps away the ear mites etc. great product.