Cyproheptadine HCl (Generic) Tablets, slide 1 of 1

Cyproheptadine HCl (Generic) Tablets, 4-mg, 1 tablet

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Cyproheptadine HCI is an antihistamine prescribed to help relieve symptoms caused by seasonal, food and plant allergies, including mild and uncomplicated allergic skin reactions, such as hives or swollen tissue. This medication may also be used to help treat asthma. Customers may receive this drug under the name Periactin.

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Cyproheptadine is indicated in the treatment of allergies and asthma. It can also be used to stimulate appetite.

Possible Side Effects

Instances of drowsiness and paradoxica (a symptom that causes excitement) have been reported.

Drug & Food Interactions

Talk to your veterinarian about any other drugs the pet is taking before starting this medication.


Cyproheptadine should be used with caution in those with a history of bronchial asthma, increased intraocular (fluid in the eye) pressure, hyperthyroidism, cardiovascular disease and hypertension.

This drug is FDA-approved for human use. However, it is common practice for veterinarians to prescribe such drugs for use in dogs and cats.

NOTE: For Generic Medications, picture displayed may not depict actual product. Generic medications may vary from one order to the next by size, color and shape depending on manufacturer. Please note product may arrive in a Chewy Pharmacy vial.

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  1. Prescribing Information

See all items by Cyproheptadine

  • Item Number
  • Generic Name
    Cyproheptadine Hydrochloride
  • Common Brand Name(s)
  • For Use With
    Dogs & Cats
  • Administration Form
  • Product Form
  • Health Condition
  • Drug Type

Cyproheptadine Hydrochloride.

Recommended Dosage

Always follow the dosage instructions provided by your veterinarian.

Storage Instructions

Store at temperatures between 68° - 77°F.


What is Cyproheptadine?

Cyproheptadine is used to treat multiple conditions in animals. In dogs and cats, it is used as an antihistamine and as a treatment for a disease called serotonin syndrome. In cats, it also works as an appetite stimulant.

What are the benefits of Cyproheptadine?

Management of serotonin syndrome and, in cats, as an appetite stimulant. Used for the treatment of allergies and asthma in pets

How is this medication given?

Use as directed by your veterinarian.

How does this medication work?

As an appetite stimulant, antihistamine and treatment for serotonin syndrome, Cyproheptadine will generally start to work within several hours, but several daysof therapy may be needed to achieve the full effect.

Rating: 3.6 of 5 stars 3 Reviews 3 Reviews 3.7 out of 5 Stars

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Rating: 3.6 of 5 stars 3.7 / 5

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3 Reviews

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  • 5 out of 5 stars

    works like a charm

    By Dora on Oct 14, 2021

    My dog is going through Chemo and has no appetite, the vet prescribed this once a day to help improve appetite and it works!

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  • 5 out of 5 stars


    By CritterSaver on Aug 13, 2019

    I rescue cats and have for many years used Cyproheptadine for those which, for various reasons, either don't eat or don't eat enough. This med works like gangbusters. I give it with a small glob of baby food chicken or turkey to disguise the pill's taste and then slowly introduce about 1 ml of low-sodium chicken broth to make sure the pill is swallowed. Both the broth and the baby food are well liked, so the pill is tolerated.

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  • 1 out of 5 stars

    Tastes terrible

    By Jenna on Apr 10, 2019

    I tried the pills and had it compounded to liquid. My cat finds both extraordinarily distasteful She drools+tries to spit it out rather than swallowing She hides from me all day rather than take it It didn't increase her weight

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