Denestra SAMe 400mg Tablet Liver & Joint Supplement for Dogs, 60 count

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$49.49 Chewy Price
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$59.39 List Price
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About This Item

Details

  • Supports liver metabolic activity and proper liver function in your pet pooch with SAMe, or S-Adenosyl-Methionine, a naturally occurring substance found in all living beings, which paw-sitively contributes to your furry friend’s health.
  • Created as a potent antioxidant and liver detoxification supplement, it aids in normal detox and cleansing of your paw-some pet’s liver from impurities and may help with exposure to heavy metal or environmental toxins.
  • Added benefits include joint health, cartilage support and maintenance of joint lubrication—making it easier for your pet to walk, run, jump and play.
  • Give this daily nutritional supplement to your fur-iend, orally or in a pill pocket, or use it with his prescription drugs.
  • Works well for your older pet or breeds prone to osteoarthritis and liver problems.

Ingredient Information

Instructions

FAQ

Questions & Answers

3 Customer Questions


what is complete ingredients

Answer by ChewyMar 11, 2021
For a complete list of ingredients, click the “Nutritional Info” tab on the product page. 

What is the dosage for a 60lb dog?

Answer by ChewyApr 16, 2020
Dosage at any time, at the recommendation or your veterinarian. Denestra should be administered on an empty stomach, one hour before or two hours after a meal (overnight fast is preferred). Do not cut or crush tablets. May be disguised in treats for easier administration.

Can it be given at feeding time.

Answer by ChewySep 22, 2022
Denestra should be administered on an empty stomach, one hour before or two hours after a meal. For the feeding information you may select the "Feeding Instructions" tab on the product page.
4.4
Rated 4.4 out of 5 stars
26 Ratings

10 Customer Reviews



Rated 5 out of 5 stars
By Echo on Nov 10, 2025

Great product for a fair price

Jax was diagnosed a year ago with a live issue that couldn’t be pinpointed what was causing it however he was put on a similar medication with these ingredients

Jax was diagnosed a year ago with a live issue that couldn’t be pinpointed what was causing it however he was put on a similar medication with these ingredients and he got better a few months later he has the same issues so they put him back on it and we also changed his diet. He went back off the medication and was great for a long time and then it happened again. So I went searching for a less expensive alternative and this was the absolute closest and almost identical medicine. So we now keep this on hand to give him when needed. Seems to work just as well! And my bank account thanks me.


Rated 5 out of 5 stars
By Linda on Sep 26, 2025

The delivery was fast n Mickey appreciated

Mickey sniffed the packaging n started clawing into it and smiling

Mickey sniffed the packaging n started clawing into it and smiling


Rated 5 out of 5 stars
By Dennis on Aug 16, 2025

Prompt shipping

Competitive pricing

Competitive pricing


Rated 5 out of 5 stars
By Jill on May 16, 2025

Vet recommended

Shipped fast and well packaged!

Shipped fast and well packaged!


Rated 3 out of 5 stars
By Mary on Jan 21, 2024

not sure we would have ordered this if we know some of constraints regarding the directions for giving the medication.

not sure we would have ordered this if we know some of constraints regarding the directions for giving the medication.


Rated 5 out of 5 stars
By Beas on Apr 16, 2023

Great option

So thankful to have a Denamarin alternative that’s a bit more economical.

So thankful to have a Denamarin alternative that’s a bit more economical.


Rated 5 out of 5 stars
By Kevin on Jul 17, 2022

Good Alternate

Good alternate cause it seems like nobody ever has the Denamarin in in stock anymore

Good alternate cause it seems like nobody ever has the Denamarin in in stock anymore


Rated 5 out of 5 stars
By Michy on Jan 30, 2021

Great product

I was told by my vet that my dog’s liver enzymes were up & needed a supplement... so I bought this product & just by the dog taking it I can tell she’s better because

I was told by my vet that my dog’s liver enzymes were up & needed a supplement... so I bought this product & just by the dog taking it I can tell she’s better because she’s playing more, where before she was just lying around...


Rated 5 out of 5 stars
By Katherine on Sep 28, 2020

Liver inflammation treatment

My 12-year-old shepherd mix had his annual physical, his blood drawn and there were some issues. Did an ultrasound and found a large mass on his liver. This was

My 12-year-old shepherd mix had his annual physical, his blood drawn and there were some issues. Did an ultrasound and found a large mass on his liver. This was prescribed by my vet for the inflammation as we are going to treat holistically only. I found out the results on a Friday afternoon, searched the Internet for this SAMe, found it on Chewy at a great price, ordered it around 10 o’clock on Friday Night and it was at my door Saturday at noon. Chewy is fabulous! Great price too. It was so nice to have the stress of finding this medication so easily, and getting it so quickly. My dog is my best friend and Chewy took care of him once again, thank you!


Rated 5 out of 5 stars
By Marguerite on Jun 12, 2020

Liver disease

My dog has the beginning of liver disease and needed this supplement

My dog has the beginning of liver disease and needed this supplement