Nutramax Laboratories Denosyl Liver & Brain Health Supplement Stabilized Tablets for Medium Dogs, 30 count

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About This Item

Details

  • This supplement contains S-adenosylmethionine (SAMe) to help increase levels of the antioxidant glutathione—one of the liver’s main detoxifying agents.
  • Support your pup’s liver, one of the most vital organs, and responsible for removing toxins, storing energy, aiding digestion, and supporting the immune system.
  • While best known for supporting the liver, the SAMe in Denosyl may help support your pet’s cognitive function, too.
  • Rest assured, Nutramax produces Denosyl to ensure your pup receives a safe, high-quality product.
  • Trust in Nutramax, a leader in pet health for over 30 years, providing a variety of supplements to boost your furry family member’s health.

Ingredient Information

Instructions

FAQ

Learn More About Nutramax From Our Team of Experts

Questions & Answers

5 Customer Questions


Does it cause constipation

Answer by ChewyMar 18, 2022
Denosyl has been shown to be well-tolerated by both dogs and cats with a wide margin of safety. We recommend consulting with your veterinarian before starting a new supplement regiment, as well as a follow-up to check on how well your pet is being on Denosyl.

Is this tablet chewable? If not, how is it recommended to administer it without food?

Answer by ChewyFeb 19, 2023
This is a tablet and should not be split or crumbled. Tablets should be given on an empty stomach for optimal absorption. They may be given at least two hours after a meal or one hour before a meal. It is recommended for pet owners to administer 3-6 cc of water immediately following any tablet administration to speed passage of the tablet into the stomach.

Can the 225mg be cut in half?

Answer by ChewySep 28, 2021
Tablets should not be cut or split. Because the tablet must be kept intact to prevent destruction by moisture, administration range is based on the nearest whole-tablet.

Does Denosyl 225 mg require a prescription

Answer by ChewyDec 16, 2020
Denosyl does not require a prescription.

4.7
Rated 4.7 out of 5 stars
155 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

83% Positive

Effectiveness

80% Positive

Ingredients

84% Positive

Long-Term Benefits

77% Positive

74 Customer Reviews



Rated 5 out of 5 stars
By chris74 on Oct 23, 2025

great size, not too big to swallow whole, clean

I used a different brand before, and the tabs (same amount of sam-e) were insanely big, and my dogs never wanted to swallow them. Denozyl tabs are small, stabilized,

I used a different brand before, and the tabs (same amount of sam-e) were insanely big, and my dogs never wanted to swallow them. Denozyl tabs are small, stabilized, and enteric coated. I think this form is the cleanest way to administer sam-e to the dog.


Rated 5 out of 5 stars
By Robert on Jun 12, 2025

A pill that works

Our Scottie has bladder cancer so is on several types of medication. She has been on chemo therapy for over 600 days and her liver enzymes have always been extremely

Our Scottie has bladder cancer so is on several types of medication. She has been on chemo therapy for over 600 days and her liver enzymes have always been extremely high, however, after being on the Denosyl tablets her liver enzymes have come down considerably. She is holding her own and we are thankful for any medication that makes her more comfortable.


Rated 5 out of 5 stars
By Elizabeth on Dec 8, 2025

The medication was sent out quickly.

My elderly dog needs it to support liver function.

My elderly dog needs it to support liver function.


Rated 1 out of 5 stars
By 08130314 on Jun 16, 2025

Poor packaging

This is not a reflection on the product as it was vet recommended and I have found that it is beneficial when given before medications that affect a dog's liver

This is not a reflection on the product as it was vet recommended and I have found that it is beneficial when given before medications that affect a dog's liver.


Rated 5 out of 5 stars
By Cynthia on Jun 17, 2025

Better price

My almost 10 year old dog had elevated liver numbers so the vet wanted him to take this. The vet charges $64/month, and Chewy was fat more affordable.

My almost 10 year old dog had elevated liver numbers so the vet wanted him to take this. The vet charges $64/month, and Chewy was fat more affordable.


Rated 5 out of 5 stars
By Jane on Jul 18, 2025

Good supplement for Dog

It supports liver, brain for my dogs, since I want them to live long as long as they can.

It supports liver, brain for my dogs, since I want them to live long as long as they can.


Rated 5 out of 5 stars
By Vanessa on Nov 4, 2025

Quick response

Mimsy seems to do well with it.

Mimsy seems to do well with it.


Rated 5 out of 5 stars
By Melyssa on Jun 12, 2025

On time

The item was on time and customer service was excellent

The item was on time and customer service was excellent


Rated 5 out of 5 stars
By cindy on Jun 20, 2025

Price

A prescription she will be on indefinitely

A prescription she will be on indefinitely


Rated 4 out of 5 stars
By Jeannette on Aug 13, 2025

Easy to take

The value and the taste

The value and the taste