NUTRAMAX Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count -

Nutramax Denosyl Tablets Liver & Brain Supplement for Large Dogs, 30 count

By Nutramax
Rated 4.5652 out of 5 stars
Breed Size

$54.99Chewy Price
$52.24Autoship Price
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About This Item


  • Denosyl contains s-adenosylmethionine (SAMe) to help increase gluthione levels to support your dog’s liver detoxification capabilities.
  • SAMe found in Denosyl has been found to enter your dog’s bloodstream to help support the liver.
  • Research has shown that SAMe may also support your dog’s cognitive function.
  • Nutramax Laboratories Veterinary Science has made supplements to support joint health, digestive health and overall wellness for over 30 years.
  • Veterinarian formulated with high-quality ingredients to ensure supplement safety.

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Nutritional Information

Feeding Instructions


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Questions & Answers

6 Customer Questions

Is this used for the rest of the pets life or until condition improves?
Answer by ChewyJan 07, 2018
We'd recommend consulting with your vet for the best administration results, it may be temporary or life long.

what is this product used for?
Answer by ChewyNov 01, 2017
Denosyl has been shown to markedly increase liver levels of glutathione, an important compound for liver health formed when SAMe (S-Adenosylmethionine) is metabolized. It has also been shown to help protect liver cells from cell death, and may help cell repair and regeneration. While best know for supporting the liver, Denosyl also has a place in supporting brain health.

Can this medicine be given crushed up or must be swallowed?
Answer by ChewyFeb 24, 2018
For optimal absorption, it is recommended to give tablet(s) whole, on an empty stomach at least an hour prior to a meal.

I have a 115 # Great Dane. What is the dosage for her? Thanks
Answer by ChewyApr 25, 2019
These tablets are formulated for dogs 35 pounds and over. For dogs 35-65 pounds, feed 1 tablet daily. For dogs 66-120 pounds feed 2 tablets daily and for dogs over 120 pounds feed 3 tablets daily. The number of tablets may be gradually reduced, or increased, at any time at the recommendation of your veterinarian.

ReviewsWrite a Review

Rated 4.5652 out of 5 stars
46 Ratings
Would recommend to a friend

46 Customer Reviews

Rated 5 out of 5 stars
By HuskyGirls on Mar 19, 2022

Better price than the Vet

So glad I discovered this at Chewy at a much lower price than the Vet charges. Vet was having an issue getting it in stock so I went searching on-line. Discovered at Chewy and no need for a script. No issues with stock and got in a couple days. My dog's vet had recommended this supplement because some of my dog's liver enzyme values are high. She has had several rounds of bloodwork, an ultrasound and liver biopsy. We still do not have an answer. Her levels have not gone down nor have they gone up. So, I cannot really say if it is actually helping but Vet recommended and I trust my Vet.

Rated 5 out of 5 stars
By Tina on Nov 20, 2021

Reduces my dogs elevated liver enzymes

Since using Denosyl, we have been able to keep my young golden retriever at a normal liver enzyme level. Whenever we discontinue this, they go back up. So glad this is an easy fix.

Rated 5 out of 5 stars
By vtlabladi on Dec 1, 2021

Great Supplement for Dogs with Cushing's Disease

My 9 year old lab was recently diagnosed with Cushing's disease and this supplement has helped to bring her blood work and overall health back into balance.

Rated 3 out of 5 stars
By JoanI on Dec 2, 2021

Not what I really wanted

Had to order these pills as a substitute instead of the normal denamarin I normally get due to being out of stock. not sure how good they will be.

Rated 5 out of 5 stars
By Truman on Nov 27, 2021

Denosyl or SAM-e for dogs is natural supplement for all senior dogs

I take this(SAM-e is technical name) and give to my beagle for cognitive decline. But it is also good for longevity, liver health and joint discomfort.

Rated 5 out of 5 stars
By Saddogmom on Jan 1, 2022

Hard to find

Best price and this strength is hard to find. My dog is in liver failure and she needs this medication

Rated 5 out of 5 stars
By Sunnyek on Nov 4, 2021

Great liver enzyme aid

My older dog’s vet recommended another product for her which is very hard to find. This one has the same component, and I add the one Denamarin has that this does not- milk thistle.

Rated 5 out of 5 stars
By DogMom on Oct 18, 2021

Helps our dog

Our vet recommended Denosyl Tablets for our dog to help support her liver. I am very happy that these can be purchased from Chewy as Chewy has the best and most efficient delivery service for pet needs.

Rated 5 out of 5 stars
By Mtnbkrwmn on Jan 10, 2022

Works well

Ordered this because denamarin was out. Worked well for us.

Rated 5 out of 5 stars
By jillceleste on Jun 2, 2021

Helped save my 6 year old doodle

New Years Eve my 5 yo (almost 6yo) Australian Shepherd/Poodle mix suddenly went lame and couldn’t lift back end of his body, became very lethargic and running a fever, we we’re out of town in Waco and rushed him to the emergency vet where they stabilized him by keeping him 25 hours on an IV and giving him meds, including denosyl. They didn’t have a diagnosis, but ran some bloodwork and his alt which is a liver specific enzyme cane back extremely high, 1480 and it’s supposed to be below 60. We got him home and followed up with his regular vet, they did an ultrasound of his liver and more bloodwork. His alt was even higher, so they started him on antibiotics and more denosyl. Its a very long story, but after 6 months of treatment, 6 or more rounds of antibiotics, steroids and taking denosyl every day for the last 6 months, he’s finally recovering! We’re tapering him off of the steroids and his alt, which was 1860 at its highest, is down to 114! Our dogs will probably be on denosyl for the rest of his life. The vet still isn’t sure what caused his issues, they originally thought cancer, but now they think it’s a reversed bile duct from the stress of moving.