Prana Pets Lignans & Melatonin with Biotin for Cushing's Disease Support for Dogs, 0-25 lbs, 90 count

Skip image gallery
Slide 1 of 11

At a Glance

  • Senior Care
  • Skin & Coat Health
  • Made in USA
  • All Lifestages

$21.42 First Time Autoship Price
this order
Save 35% (up to $20) today when you set up Autoship. 
$31.30 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$32.95 Chewy Price
($0.37 /ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE 1-3 day delivery on first-time orders over $35
Free 365-day returns

No interest if paid in full in 6 months on PayPal purchases of $149+. .

About This Item

Details

  • This herbal remedy helps reduce the extreme thirst and excessive urination associated with Cushing’s disease.
  • Added biotin supports healthy skin, coat, and nails.
  • A combination of melatonin and flaxseed lignans helps your furry friend maintain a normal hormonal balance.
  • By reducing thirst, these tablets can also alleviate excessive urination.
  • Lignans and Melatonin Blend may help relieve your pal’s constant panting.

Ingredient Information

Feeding Instructions

Learn More About Prana Pets From Our Team of Experts

Natural Remedies from Prana Pets

Prana Pets helps pets—and their people—live their best lives with natural remedies that ease common issues and support whole-body wellness. With Prana Pets as your holistic health partner, you can feel confident you’re giving your pets the best.

Ingredients Backed By Science

These proprietary formulas are crafted just for cats and dogs using premium, human-grade ingredients. Backed by science and rooted in nature, each blend is designed to support your pet’s health with the safest, most effective natural remedies.

Only The Good Stuff

Prana Pets formulas are free from unnecessary fillers and made with only high-quality, purposeful ingredients. Every drop, chew or scoop is packed with the natural goodness your pet needs—nothing more, nothing less.

Safety You Can Trust

Prana Pets products are vet-recommended and made in the USA in FDA-inspected, cGMP-compliant facilities. They are third-party lab tested for safety, purity, and quality, so you can feel confident giving your pet natural support you can trust.

About Prana Pets

At Prana Pets, everything they do is fueled by unconditional love—the same kind our pets show us every day. From carefully crafted formulas to caring customer support, they’re there to help you return that love with the best care possible.

Shop Prana Pets

Frequently bought together

Questions & Answers

10 Customer Questions

Can this product be returned if the seals are in tact meaning the product hasn’t been used at all?

How much melatonin is in each tablet? Thanks.

Answer by Chewy • Jan 23, 2022
This medicine includes 3 milligrams of melatonin per tablet.

Should a single dose be given per day or split into two doses

Answer by Chewy • Oct 16, 2021
The dosage amount is recommended to be given once per day. Dog's under 10 pounds get 1 tablet daily and dog's up to 25 pounds get 2 tablets daily.

Can i give this to my dog as well as Vetoryl? Thank you

Answer by Chewy • Dec 31, 2021
If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.
Reviews
Write a Review
4.5
Rated 4.5 out of 5 stars
156 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

82% Positive

Effectiveness

86% Positive

Ingredients

83% Positive

Side Effects

83% Positive

66 Customer Reviews

Always consult a veterinarian about your pet’s health needs. Customer reviews should not be used as medical advice.

Rated 5 out of 5 stars
By stephanie on Dec 7, 2025

The ingredients

I year ago my little Abras bloodwork came back with a severely high spike liver enzyme. And I did not want her to go through any liver disease or cushings. So I

I year ago my little Abras bloodwork came back with a severely high spike liver enzyme. And I did not want her to go through any liver disease or cushings. So I started cooking her own food, I ordered this as an additive for nutrients and it looked like a great product for aging dogs. 1 year later, I took her for her bloodwork and everything was in normal range , she is 14 and has no arthritis and now has the energy of a puppy. The vets were blown away , and asked me what I was doing. Her hair is silky like a pup. My groomer is excited about her fluffy silky hair,and calls her Benjamin Button! So from my data proven testimony moved me to share this and say buy this product. It really works.

Rated 5 out of 5 stars
By Melissa on Jan 16, 2026

Works for controlling our blood glucose!

Cushing's is a terrible disease! We used this product in conjunction with our insulin and it is a much easier and gentle way to help with the 2 diseases . Diabetes

Cushing's is a terrible disease! We used this product in conjunction with our insulin and it is a much easier and gentle way to help with the 2 diseases . Diabetes sucks . Cushing's sucks. They both are hard on any baby... This supplement helped us control the glucose level.. and rid her of that barrel chest you often see .. I will never be without it!

Rated 4 out of 5 stars
By Julia on Jan 9, 2026

Tablets work/ed

Started giving the tablets along with the adrenal balace drops about Dec 1st. Within the 1st week, noticable decrease in thirst. It is nearly 6 weeks into the process

Started giving the tablets along with the adrenal balace drops about Dec 1st. Within the 1st week, noticable decrease in thirst. It is nearly 6 weeks into the process and not only is there still "normal" drinking, but fur has started to regrow and skin looks much better. Dog is 14 years old and has other medical conditions, but she is doing great. I would recommend this product.

Rated 5 out of 5 stars
By Adryan on Jan 5, 2026

Great Supplement

Our boy, Charlie, is 15.5. He was diagnosed with Cushings about a year ago. After starting the Cushings med he had a medical emergency which made the medication

Our boy, Charlie, is 15.5. He was diagnosed with Cushings about a year ago. After starting the Cushings med he had a medical emergency which made the medication no longer an option. Then we found this supplement & it has helped him tremendously. He had extensive bilateral hair loss and he had full regrowth within 2-3 months of starting this product.

Rated 5 out of 5 stars
By susan on Nov 12, 2025

Helping!

The Vet says it is very likely my dog (Chihuahua/Terrier) has Cushings. Due to his age I did not want to go down the rabbit hole of more expensive tests. This

The Vet says it is very likely my dog (Chihuahua/Terrier) has Cushings. Due to his age I did not want to go down the rabbit hole of more expensive tests. This seems to be helping. He is still very hungry (but he has always been a hungry boy) and was drinking a lot more than normal, but it has slowed down. I saw some improvement in a couple of days which seems very fast and maybe that is just coincidence, but I'll take it! He has had no tummy issues. Praying he will continue to improve. I just add to his food and he gobbles it up. I know this is not going to cure it, but for now he is doing well.

Rated 2 out of 5 stars
By Kristen on Dec 29, 2025

No noticeable difference so far

I have been adding this to the food I give Gladys since I received but I haven’t noticed any change in her symptoms so far. She doesn’t mind the flavor though so

I have been adding this to the food I give Gladys since I received but I haven’t noticed any change in her symptoms so far. She doesn’t mind the flavor though so that’s a positive. I will continue until the bottle is gone ti see if there is any change.

Rated 3 out of 5 stars
By Kelly on Oct 14, 2025

Can't really say that it helped.

This was easy to give to my senior boy dog for the last year or so. But I honestly dk if it really helped. He was on this and the drops, other vitamins, plus prescription

This was easy to give to my senior boy dog for the last year or so. But I honestly dk if it really helped. He was on this and the drops, other vitamins, plus prescription meds and I kept hoping that the combination of everything would work together for good. Sometimes I'd get a glimpse of hope that things were working, and then 3 days later he'd have a temper tantrum and be very difficult to live with. Almost as if the cortisol was building up in his body, with no place to go, so eventually he would explode with anger, thus releasing the cortisol or using it up, and then I'd have a week or two where things were more calm, only for the pattern to repeat itself. Wish that I had a better review. Perhaps you will have better success with your dog and the product, than I did.

Rated 5 out of 5 stars
By Misty on Nov 1, 2025

Great customer service

Chewy went above and beyond with their customer service. I had reordered this for my dog but she was old and quickly declined and passed. When I updated chewy they

Chewy went above and beyond with their customer service. I had reordered this for my dog but she was old and quickly declined and passed. When I updated chewy they refunded me and let me know I can donate the items. On top of that they sent me flowers with their condolences. I’ve never experienced such wonderful and caring services from a company. Thank you Chewy.

Rated 4 out of 5 stars
By Mary on Jan 16, 2026

I have high hopes

Bought this to try for Cushings. The vet it wouldn’t hurt her. Too soon to tell anything though.

Bought this to try for Cushings. The vet it wouldn’t hurt her. Too soon to tell anything though.

Rated 5 out of 5 stars
By Wendy on Jan 12, 2026

Helps My Cushing’s Pup

My dog didn’t tolerate prescription meds for Cushing’s well, but this supplement seems to help.

My dog didn’t tolerate prescription meds for Cushing’s well, but this supplement seems to help.