Project Paws SAM-e Advanced Liver Support Dog Supplement, 60 count

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Project Paws SAM-e Advanced Liver Support Dog Supplement can help maintain proper liver health and brain function in your four-legged best friend. It contains S-Adenosyl Methionine (SAM-e), an active ingredient that can help protect against liver damage – which is especially important if your paw-tner is taking an NSAID for pain relief.

Key Benefits
  • Helps protect your dog’s liver from damage, helps support cell growth, and helps reduce canine cognitive dysfunction.
  • Includes amino acids, B vitamins, B6 and zinc.
  • Helps support proper liver function if he’s taking NSAIDs for pain relief.
  • For medium to large dogs.
  • Made in the USA.

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  • Item Number
  • Weight
    8 ounces
  • Lifestage
    Adult, Senior
  • Breed Size
    Small Breeds, Medium Breeds, Large Breeds, All Breeds, Giant Breeds, Extra Small & Toy Breeds
  • Food Form
  • Product Form
Nutritional Info

Active ingredients: S-Adenosyl Methionine, N-Acetyl Cysteine, L-Taurine, Zinc Ascorbate, Vitamin B, (Pyridoxine HCl) B-Complex Proprietary Blend.

Feeding Instructions
Weight Daily Dose
13-40lbs 1 Tablet
41-90lbs 2 Tablets
Over 90lbs 3 Tablets

Tablets should not be broken as the enteric coating of our SAM-e Advanced tablets protects the active ingredients from destruction while in the stomach. Tablets should not be split or crumbled. Absorption of SAM-e Advanced is decreased when it is given with a meal. For optimal absorption, administer tablets at least one hour before feeding your dog. For owners who find it difficult to administer SAM-e Advanced to your dogs, the tablets may be disguised in a small bite of moist food or a treat. DO NOT withhold water from your dog when giving tablets.


Storage: Tablets are sensitive to moisture and heat. Store in temperature and humidity controlled environment.


Why should I include vitamins & supplements in my pet’s diet?

Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet’s exact health needs. Like in humans, vitamins and supplements can help support your pet’s long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.

How often should I give this supplement to my pet?

It is recommended to give the suggested dosage based off your pet’s weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.

Is this supplement safe to use with the medication my pet is currently taking?

If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.

My pet is allergic to certain ingredients, will this product be safe to use?

For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.

Does this product come in other product forms?

For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.

Rating: 2.4 of 5 stars 5 Reviews 5 Reviews 2.4 out of 5 Stars

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60% Recommend

60% of reviewersrecommend this product

Rating: 2.4 of 5 stars 2.4 / 5

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  • 1 out of 5 stars

    Useless if your dog won't eat them

    By chews on Aug 25, 2021

    They need to make these in a flavored wafer form or something. These things are useless because my dogs won't eat them. Even with a dalipe of butter!!!

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  • 4 out of 5 stars

    Seams to work

    By Zeus on Feb 13, 2021

    My senior dog had moderately elevated ALP liver enzyme. I wanted to support his body as naturally as possible. I tried this along with Organic Milk Thistle. After 6 weeks on both products, his ALP came down to a level that my vet says is only "mildly" elevated. I will continue to use to see if it will come down more. I gave 4 stars instead of 5 because it's pretty expensive!! The bottle only lasts 30 days for my 75lb dog.

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  • 1 out of 5 stars


    By rachel on Jun 3, 2021

    I almost threw up when I opened the bottle, these pills smelled so bad. I can not give these to my dog.

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  • 1 out of 5 stars

    too big and hard

    By Murph on Jan 26, 2021

    I can't get my dog to take these, they are too big and hard, I've tried all the tricks and she just won't take them.

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  • 5 out of 5 stars

    Medicine for dog

    By Trin on Jan 4, 2021

    So far so good, much cheaper than what the vet charged and seems to work just as good.

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