Synovi G4 Soft Chews Joint Supplement for Dogs, 240 count
At a Glance
Hip & Joint Support
All Lifestages
All Breeds


Count:
Count:
About This Item
Details
- First step in a total joint health management protocol
- Combines joint health agents boswellia serrata extract, turmeric, glucosamine, MSM, creatine, perna canaliculus, vitamins C and E and other antioxidants
- Supports overall joint function and flexibility, and helps strengthen joint cartilage in dogs as they age
- Contains a synergistic blend of antioxidants to help fight free radicals and maintain a healthy lifestyle
- Tasty, highly palatable soft chew form makes administering to your dog easy and enjoyable
Ingredient Information
Active Ingredients: Glucosamine HCl (Shellfish), Methylsulfonylmethane (MSM), Creatine Monohydrate, Boswellia Serrata Extract (Containing 65% Boswellic Acids), Perna Canaliculus, Proprietary Blend of Dicalcium Phosphate, Citrus Bioflavonoids, Ascorbic Acid (Vitamin C), Manganese Sulfate, Grape Seed, Extract, Zinc Sulfate and Alpha Lipoic Acid, Curcuma Longa (Turmeric), Selenium (as L-Selenomethionine), D-Alpha Tocopheryl Acetate (Vitamin E).
Inactive Ingredients: Cane Molasses, Corn Starch, Dried Poultry Liver, Glycerin, Lecithin, Mixed Tocopherols, Potassium Sorbate, Soybean Oil, Sugar, and Wheat Flour.
Instructions
Can be given during or after meal time. Administer during or after the animal has eaten to reduce incidence of gastrointestinal upset.
FAQ
Synovi G4 builds upon the success of the Synovi G3 matrix, a blend of various joint health ingredients, including glucosamine, manganese and green-lipped mussel, which has sold over 250 million doses. Synovi G4 is enriched with the naturally-derived ingredients turmeric, a potent antioxidant, and Boswellia serrata. Laboratory studies have shown that Turmeric and Boswellia serrata help support a healthy inflammatory response.
What is Boswellia serrata? Boswellia serrata, also known as Indian frankincense, is a large branching tree native to India, Northern Africa, and the Middle East. The tree's resin contains boswellic acids, which have shown in laboratory studies to support a healthy inflammatory response and promote joint health. Boswellia serrata may also help with occasional discomfort and joint stiffness due to daily activity.
What is Turmeric?
A plant of the ginger family native to Asia and India most commonly associated as a spice for cooking. The active component, curcumin, is a yellow phytochemical extracted from the plant's roots. It contains free radical scavenging abilities and has shown to assist in the synthesis of important cellular enzymes.
Synovi G4 is based on the joint health ingredient matrix found in Synovi G3 which contains Perna canaliculus, also known as Green-lipped mussel, found off the coastal waters of New Zealand. Perna is a source of chondroitin as well as Omega-3 fatty acids.
These two ingredients were added because they are not commonly found in traditional joint supplements and are known for a variety of health benefits. A growing body of evidence indicates that both Boswellia and Turmeric may be beneficial in the support of healthy joints, including cartilage and connective tissue, as well as a healthy inflammatory response.
How can I use Synovi G4? Synovi G4 can be used as a standalone product or in coordination with Free Form' and/or Alenza Soft Chews for additional supplemental support or as directed by your veterinarian. Joint supplements are typically given to dogs that are starting to age, may be slowing down, or have trouble climbing stairs. For active dogs, a joint supplement can also help maintain joint health and mobility.
There are no known contraindications for Synovi G4 but always tell your veterinarian about all the medications and supplements that you give your dog.
What can I expect after giving Synovi G4 to my dog? It varies depending on a wide scope of factors, such as lifestyle, genetic predispositions, body condition, and type of discomfort. It is possible pet owners may notice some benefit within 2-4 weeks.
No. Synovi G4 is labeled for use in dogs only.
How should Synovi G4 be stored? Store at room temperature in a location your dog can't access.
Synovi G4 is provided in a tub and should be kept sealed and stored at room temperature when not in use. It does not require refrigeration or any other special storage.
Synovi G4 can be given during or after meal time.
| Weight | Maintenance Recommendations |
|---|---|
| 5 to 15 lbs | 1/2 chew every other day |
| 16-30 lbs | 1/2 chew daily |
| 31-60 lbs | 1 chew daily |
| 61-100 lbs | 2 chews daily |
| Over 100 lbs | 2 1/2 chews daily |
No. Please follow the maintenance recommendations as listed on the product label.
Assuming only one dog is receiving Synovi G4, each tub count will last according to the table below:
| 60 count | 8 months | 4months | 2 months | 1 month | 24 days |
|---|---|---|---|---|---|
| 120 count | 16 months | 8 months | 4 months | 2 months | 48 days |
| 240 count | up to 24 months | 16 months | 8 months | 4 months | 3 months |
What is the protein source for Synovi G4 (flavor)?
Poultry liver.
Synovi G4 is not intended for patients with known hypersensitivity to any of the ingredients in the product.
The National Animal Supplement Council is a nonprofit industry group dedicated to protecting and enhancing the health of companion animals throughout the U.S. The overriding goal of the NASC is to promote the health and well-being of cats and dogs that are given animal health supplements by their owners, and to protect and enhance the integrity of the animal health product industry.
The NASC Quality Seal program was initiated as part of the NASC's ongoing effort to improve and standardize the animal supplement industry.
The Quality Seal is a way for consumers to know the product they are buying comes from a manufacturer that voluntarily complies with standards set forth by NASC.
NASC member companies must comply with rigorous requirements before they are granted permission to display the seal:
When you see the Quality Seal on a product, you can trust it comes from a reputable company that has successfully passed an independent quality audit.
Look for the NASC Quality Seal on Synovi G4 and all Bayer supplements.
Most commercial pet foods include baseline vitamins and nutrients, but some may not have the adequate amount to suit your pet's exact health needs. Like in humans, vitamins and supplements can help support your pet's long-term health, regulating everything from digestion to muscle growth. Consult your veterinarian to determine the best vitamins and supplements for your furry friend.
It is recommended to give the suggested dosage based off your pet's weight. Please refer to the Feeding Instructions tab and consult with your veterinarian for more information.
Is this supplement safe to use with the medication my pet is currently taking?
If your pet has a medical condition and is taking other medication, we recommend consulting with your veterinarian to ensure that this supplement is safe to use.
For a complete list of ingredients, click on the 'Nutritional Info' tab, next to the 'Description' tab, just under the product photos. If you are unsure about the safety of this product for your pet, we recommend consulting with your veterinarian.
For a complete assortment of products by the manufacturer of this supplement, click on the link next to the item name at the top of the page. You can also find an assortment of supplements across all product forms on our page.


Vet-formulated Pet Supplements
Pet Protect offers a variety of supplements for dogs and cats. Whether your pet needs support for joint health, digestive health, skin health, seasonal allergies, stress, or everyday health and wellness, Pet Protect has their back.

Hip & Joint+ Soft Chews for Dogs Formulated with Synovi G4—a vet-developed blend of glucosamine, Boswellia serrata, turmeric, and manganese—plus creatine, MSM, and antioxidants like vitamins C & E to promote joint flexibility, cartilage and muscle recovery for advanced support.

NASC Quality Seal
Every Pet Protect product is backed by the National Animal Supplement Council (NASC), a trusted industry group that upholds the highest standards for quality and safety. Only brands that meet their strict requirements earn the NASC Quality Seal.

Proprietary Blends Backed by Science
Pet Protect proprietary blends are more than just combinations of ingredients; they're the result of veterinary expertise and scientific research. Each formula is designed to target your pet’s specific needs with effective, high-quality ingredients.

About Pet Protect
From the makers of Advantage—a trusted leader in pet health for 25 years—Pet Protect supplements are designed to support your pet’s healthy, active lifestyle. Made in the USA with globally sourced ingredients, each product reflects a commitment to quality.
Questions & Answers
22 Customer Questions
Is there no Chondroitin in these ?
How many grams of fat are in one of these chews?
Where are the ingredients sourced? If from overseas, what is done to certify the quality and safety of the products?
What's the Calorie count on these. My dog is on a strict calorie count due to her being overweight.
Customers Mention
Active Ingredients
Dosage and Administration
Effectiveness
Quality and Purity
725 Customer Reviews
Quality Supplement - At least it was
Back when it was a Bayer product, this was the supplement my Boxer's Orthopedic Vet recommended after her TTA. She did amazing with it. (That was a few years ago)
Back when it was a Bayer product, this was the supplement my Boxer's Orthopedic Vet recommended after her TTA. She did amazing with it. (That was a few years ago) Currently is seems different, and my current dog turns her nose up to it. Even her favorite "cover up treats" to disguise it won't work. Even other dogs I know who are not picky about food at all turn their noses up at it. I gave it 3 stars because I believe it would still be a good supplement. But it's not good if you can't get a dog to eat them.
Product change is disappointing.
I have been purchasing Synovi G4 Hip and Joint chews since 2018. I am very disappointed with the new packaging and pricing of this product. This has been stated
I have been purchasing Synovi G4 Hip and Joint chews since 2018. I am very disappointed with the new packaging and pricing of this product. This has been stated from other reviewers as well. The 240 chews only last for two months now instead of 4 months with a hefty price increase as well. The chews are stuck together in a sticky mess where you have to attempt to pull off an estimated dose of the medication. I doubt I will continue to purchase or recommend this product in the future.
Reduced quality - double the price!
I purchased these for our dogs for YEARS! I was always very happy with these. For years the came in the tube and the servicing size for my dogs was 2 a day. Now
I purchased these for our dogs for YEARS! I was always very happy with these. For years the came in the tube and the servicing size for my dogs was 2 a day. Now they changed the product, sell it in a pouch, they reduced the size by 1/2 and they are gross and crumbly when they arrive. I know have to give 4 as a serving size. So, basically they cut the size in 1/2 but charge the same for the same amount and you have to double the dosage. Will find something new as this is a disgrace!
Poor Quality
I have been giving these to my dog for 6 years now and have seemed to help with his joints and mobility. Now that the product has changed packaging and dosage along
I have been giving these to my dog for 6 years now and have seemed to help with his joints and mobility. Now that the product has changed packaging and dosage along with the size of the product the quality has declined. Not to mention the price is way more than it used to be. The last bag came in one big lump with the treats stuck together and the bottom of the bag full of liquid. I will most likely be looking for a replacement for the future.
Why We’ll Always Come Back to Chewy
We absolutely love Chewy and this order was a great reminder of why. While we previously had a bad experience that was due to FedEx (not Chewy), we decided to give
We absolutely love Chewy and this order was a great reminder of why. While we previously had a bad experience that was due to FedEx (not Chewy), we decided to give them another try because we’ve always loved their customer service, and they didn’t disappoint. This order arrived smoothly and everything was perfect. Chewy consistently goes above and beyond for their customers and pets, and we’re so glad we stuck with them. Highly recommend!
My vet recommended these
My 12 year old German Shepherd loves to fetch ball. She runs so hard that her right hip started hurting her. It was very painful and noticeable. My vet recommended
My 12 year old German Shepherd loves to fetch ball. She runs so hard that her right hip started hurting her. It was very painful and noticeable. My vet recommended giving her Synovi g4 and shortening the distance we threw her ball. And shortening her time playing by just a little. And it made a big difference. So far she still plays and no pain or limping. Love this product!!
Difficult to Separate
New packaging - a pouch - and configuration of the chews (smaller and very soft & stuck together) and dosage recommendations have brought me to the point of choosing
New packaging - a pouch - and configuration of the chews (smaller and very soft & stuck together) and dosage recommendations have brought me to the point of choosing a different brand of joint supplement next time around. The pouch packaging results in a glob of chews that are often broken up, hard to separate, and difficult to ascertain at times how much constitutes one chew.
Product quality has declined
Our dog has been on this for a number of years ever since our vet recommended it. Sadly over the past 6 -8 months it’s changed. It used to be shipped in a box
Our dog has been on this for a number of years ever since our vet recommended it. Sadly over the past 6 -8 months it’s changed. It used to be shipped in a box. The morsels were a good size and didn’t fall apart and my dog only required 1 twice a day. Now the morsels have shrunk by half and they ship into a bag which causes the morsels to stick together and more often than not they are broken apart so you don’t know if you are giving enough. Additionally the packaging now says based on my dog’s weight (which hasn’t changed) he has to have 2 morsels twice a day. And the cost of the product has increased. I no longer think it’s effective and I’ve had to switch to something else. I can’t recommend this product.
Not happy with Bayer
I have been giving my dogs Synovi G4’s for the last nine years and have been very happy with the product when it was produced by Elanco. This time however I received
I have been giving my dogs Synovi G4’s for the last nine years and have been very happy with the product when it was produced by Elanco. This time however I received the “new” Bayer version and was shocked to find that I paid the same price for smaller chewable that were essentially half the dosage of the older version, basically a 100% increase in price. Not only that but they were sticky and wadded together in a big clump. I will not be buying this product again.
Substitute Product - Poor Quality
For years we have order Synovi G4 Chews, which were packaged in a plastic tub and recently that product was no longer available. This substitute was suggested and
For years we have order Synovi G4 Chews, which were packaged in a plastic tub and recently that product was no longer available. This substitute was suggested and it arrived with the chews all stuck together and / or crumbled in pieces. I will be cancelling all future orders and search for a comparable substitute. The one star is b/c they make select at least one. I give it ZERO Stars!