Vetoquinol Zylkene 225-mg Capsules Calming Supplement for Medium Dogs & Cats, 120 count

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At a Glance

  • Calming
  • All Lifestages
  • Medium Breeds
$165.99 First Time Autoship Price
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$185.99 Chewy Price
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About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax cats and dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 225 mg capsules that can be given by mouth, or opened and mixed with a meal.

Ingredient Information

Instructions

FAQ

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Questions & Answers

1 Customer Questions

How long does it take Zylkene to work?

Answer by Chewy • Aug 07, 2023
It should take between 30 minuets to 1 hour. This will depends on the metabolism of the pet.
Reviews
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4.5
Rated 4.5 out of 5 stars
42 Ratings
Terms & Conditions

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Effectiveness

85% Positive

Form and Administration

81% Positive

Ingredients

76% Positive

Nutritional Value

78% Positive

19 Customer Reviews

Rated 5 out of 5 stars
By Carol on Oct 22, 2025

Vet recommended calming medication

Our dog has seizures. When our vet first recommended medications for her, she included Zylkene as an alternative to stronger prescription medications. It has helped

Our dog has seizures. When our vet first recommended medications for her, she included Zylkene as an alternative to stronger prescription medications. It has helped to calm her although she still needs stronger medications to suppress her seizures. The good thing about Zylkene is that it can be used when needed if for some reason she becomes anxious or agitated. We can also give it to our other dog if she needs calming.

Rated 4 out of 5 stars
By Gabriella on Sep 10, 2025

This works!

Look for smaller changes in mood. We split one capsule amongst 3 cats. We started with a loading dose, splitting one capsule twice daily. We noticed after 2 weeks

Look for smaller changes in mood. We split one capsule amongst 3 cats. We started with a loading dose, splitting one capsule twice daily. We noticed after 2 weeks a more serene family of cats! We now give once nightly with dinner and it still works. I have tried this in the past and didn’t document the changes so I didn’t see that it worked. But it really does. Don’t give up.

Rated 5 out of 5 stars
By Beth on Jun 3, 2025

Supplement that really works

People often recommend supplements to help you solve the problem with a pet, but it can be hard to tell if the supplement is working ornot. Do you think maybe you

People often recommend supplements to help you solve the problem with a pet, but it can be hard to tell if the supplement is working ornot. Do you think maybe you see a tiny improvement, or maybe an intermittent improvement? But you're not really sure? But this product most definitely does work. I Foster a lot of High needs, traumatized, and new mother, cats for our local shelter. These cats are often stressed so badly that they won't . They won't groom themselves. They're just totally shut down. When I start them on this supplement, they usually feel settled enough to eat bythe next morning. This is super important when I'm fostering a mama kitty with new babies, who really needs to eat in order to keep making milk and caring for the babies. There's not much time to lose with appetite problems when you have 6 to 8 tiny babies, depending on the mama kitty nourishing herself and drinking water. My house is never without a large bottle of this product so that the minute I see signs of stress related starvation, I can turn it around.

Rated 1 out of 5 stars
By James on Nov 30, 2025

Doesn't work for my cat.

It isn't the product. I have a seriously messed up cat.

It isn't the product. I have a seriously messed up cat.

Rated 1 out of 5 stars
By Judith on Sep 26, 2025

i didn't order this

i hope i wasn't charged. the kitty this was for passed away a long time ago.

i hope i wasn't charged. the kitty this was for passed away a long time ago.

Rated 5 out of 5 stars
By Stephen on Apr 15, 2025

Zylkene worked for Joe

We've tried a lot of medications for our anxious Jack Russell mix. This is the only one that has made a difference. Our vet advised that not all dogs will get a

We've tried a lot of medications for our anxious Jack Russell mix. This is the only one that has made a difference. Our vet advised that not all dogs will get a benefit because not all dogs have the "receptors" that allow it to work, so she gave us a trial Rx and it did work. We then order a 90 count capsul from Chewy at a much better price.

Rated 5 out of 5 stars
By Jacqueline on Sep 8, 2025

Results

This def helps my doggo chill out and not stress as much.

This def helps my doggo chill out and not stress as much.

Rated 5 out of 5 stars
By paul on Sep 22, 2025

It wasn't damaged

The last two calm and cool orders where damaged

The last two calm and cool orders where damaged

Rated 5 out of 5 stars
By Mindy on Oct 25, 2025

Stress medication

And they work great

And they work great

Rated 5 out of 5 stars
By Wendy on Nov 7, 2024

It's helping our Beagle mix

Our girl is very reactive and Zylkene was recommended by our vet. The Zylkene is helping her stay calm long enough in some instances that she can respond instead

Our girl is very reactive and Zylkene was recommended by our vet. The Zylkene is helping her stay calm long enough in some instances that she can respond instead of just reacting. It's early times yet but seems to be helping her.