Vetoquinol Zylkene 450-mg Capsules Calming Supplement for Large Dogs, 120 count

Skip image gallery
Slide 1 of 8

At a Glance

  • Calming
  • All Lifestages
  • Large Breeds
$259.99 First Time Autoship Price
this order
Save 40% (up to $20) today when you set up Autoship. 
$265.99 Autoship Price
(-5%) future orders
  • Keep saving 5% on every order
  • Get deliveries on your schedule
  • Skip, change, or cancel anytime
$279.99 Chewy Price
($2.34 /ea)
Promo, New Customers Only: Spend $49+, Get $20 eGift Card + Free Shipping with code: WELCOME
In Stock
FREE 1-3 day delivery
Free 365-day returns

No interest if paid in full in 6 months. .

About This Item

Details

  • The only veterinary supplement formulated with alpha-casozepine, a natural ingredient from cow’s milk with calming properties to help relax dogs.
  • Non-drowsy formula provides a sense of calm and contentment without tranquilizing or sedating your pal.
  • Perfect to use before or during stressful situations, including moving, adapting to new people or new places, traveling, vet visits, and for behavior training.
  • Free of lactose and preservatives, so it’s ideal for pets with sensitive tummies; used by veterinarians and animal behaviorists worldwide.
  • Formula comes in 450 mg capsules that can be given by mouth, or opened and mixed with a meal.

Ingredient Information

Instructions

FAQ

Learn More About Vetoquinol From Our Team of Experts

Frequently bought together

Questions & Answers

Be the first to ask a question.
Reviews
Write a Review
4.5
Rated 4.5 out of 5 stars
21 Ratings
Terms & Conditions

10 Customer Reviews

Rated 5 out of 5 stars
By Vivian on Apr 17, 2025

Works great

I have a dive with separation anxiety. This helps do much

I have a dive with separation anxiety. This helps do much

Rated 5 out of 5 stars
By Stephanie on Oct 18, 2024

Works well at taking the edge off of anxiety

This has worked really well as a daily supplement for our Great Dane to take his anxiety down a notch or two. The only complaint is the price

This has worked really well as a daily supplement for our Great Dane to take his anxiety down a notch or two. The only complaint is the price

Rated 1 out of 5 stars
By Maureen on Jul 22, 2024

Didn't help

I got this thru my vet. My rescue dog was going thru the roof with anxiety which is understandable. He weigh 30#, the vet prescribed him the 450 mg. No improvement

I got this thru my vet. My rescue dog was going thru the roof with anxiety which is understandable. He weigh 30#, the vet prescribed him the 450 mg. No improvement. She then said give 2 chews which I did but weaned him off, too expensive for something that didn't work. What has helped him? A simple calming collar. Go figure. I would not recommend but the rest of the reviewers had success. Just have to do trial and error.

Rated 1 out of 5 stars
By liam on Sep 8, 2024

BIGGEST (SCAM)

Ive Been Raising Dogs Over 33 Yrs, This VETOQUINOL Is The Biggest Rip Off Does Not Work It Should Be Taken Off Website I Back Chewy And Products Like This Are Bad

Ive Been Raising Dogs Over 33 Yrs, This VETOQUINOL Is The Biggest Rip Off Does Not Work It Should Be Taken Off Website I Back Chewy And Products Like This Are Bad News !

Rated 5 out of 5 stars
By Angela on Jul 17, 2024

It helps !!!

Lillie Girl, our fully energized Australian Kettle Dog and Husky Mix likes it and she gets calmer what makes us both smile.

Lillie Girl, our fully energized Australian Kettle Dog and Husky Mix likes it and she gets calmer what makes us both smile.

Rated 5 out of 5 stars
By Lisa on Oct 14, 2024

this actually helps for calming when taken for a while

we have had several dogs use this over the years

we have had several dogs use this over the years

Rated 5 out of 5 stars
By Udele on Jan 4, 2024

I love this product

My large dog has issues with my other dog when he isn't feeling well. Ex. Upset stomach, diarrhea, car rides. I give him 2 of these those mornings that I see the

My large dog has issues with my other dog when he isn't feeling well. Ex. Upset stomach, diarrhea, car rides. I give him 2 of these those mornings that I see the signs and he is so much calmer and a totally different dog. Pricy but I would recommend to anyone who us experiencing similar issues.

Rated 5 out of 5 stars
By Ellen on Apr 20, 2024

Just what the veterinarian ordered.

My Doberman has been taking Xylkene for about 18 months. It has helped his anxiety.

My Doberman has been taking Xylkene for about 18 months. It has helped his anxiety.

Rated 5 out of 5 stars
By Christine on Sep 27, 2023

This stuff has been the best stuff for my four year old lab. He is so much more calmer.

This stuff has been the best stuff for my four year old lab. He is so much more calmer.

Rated 5 out of 5 stars
By Carol on Jul 12, 2023

Helpful

This medicine had helped my 3 year old Weinmaraner remain calm in the face of stressful conditions

This medicine had helped my 3 year old Weinmaraner remain calm in the face of stressful conditions