VetriScience VETRI SAMe 225 S-Adenosyl-Methionine Liver Detox Supplement Tablets Liver Supplement for Medium & Large Breed Dogs, 30 count

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About This Item

Details

  • This supplement helps support optimal liver health and function and maintain normal liver enzyme levels.
  • Each tablet contains S-Adenosyl-Methionine to help support your furbaby’s liver detox.
  • The tablets are coated to protect the active ingredients from stomach acid, ensuring the nutrients are properly absorbed for maximum benefit.
  • These tablets may help promote healthy cognition and mental clarity in aging dogs.
  • This supplement is a handy way to promote long-term liver health support for your best friend.

Ingredient Information

Instructions

FAQ

Powerful Detox to Fuel Every Mile

VetriScience liver supplements are specifically developed to complement veterinary care plans for healthy detoxification. Science-backed, condition-specific formulas are made with premium ingredients and trusted by veterinarians everywhere to support liver health at every stage of life.

Advanced Formulas with Premium Ingredients

S-Adenosyl-Methionine (SAMe)

Essential for maintaining healthy liver detox.

 

Milk Thistle

Supports optimal glutathione levels & healthy liver regeneration.

 

Artichoke Leaf

Promotes healthy bile production & flow in the liver.

Clean Support for Life in Motion

Condition-specific formulas are made by vets, for vets. Available now to pet owners in a variety of formats to provide a perfect fit for every breed, size, and age.

  • Promote full-body health
  • Support healthy liver detox
  • Maintain healthy SAMe & glutathione levels
  • Promote optimal liver circulation
  • Help promote healthy inflammation
  • Keep senior dogs thriving

Designed for Vets. Made for Your Pet.

VetriScience was born in vet clinics. Our condition-specific formulas were designed by veterinarians to meet the unique health needs of dogs and cats, and they've been used in veterinary health plans for decades. We use formulas made with powerful levels of clinically supported ingredients—without fillers, hidden ingredients, or harmful preservatives.

About VetriScience

For over 40 years, VetriScience has helped pets live a life without boundaries. Premium pet supplements are formulated by veterinarians, recommended by pet professionals, and trusted by champions. VetriScience is committed to using only pure and highly researched ingredients to produce quality products that are safe, effective, and delicious!

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Questions & Answers

14 Customer Questions


Is there a difference in size of pill with 225mg and 90 mg?

Answer by ChewyJan 28, 2019
There is a difference in the size of the pill. The 225 mg is bigger.

If my dog should get 2 pills per day for her weight, do I give them 2 at once or 1 two times a day?

Answer by ChewyAug 30, 2019
For best results, give recommended amount on an empty stomach one hour prior to feeding.

What size is the Vetri Sam-e 225 pill approximately?

Answer by ChewySep 20, 2019
These tablets are approximately the size of four dimes stacked together or 17 millimeters by 7 millimeters.

Does this help support my dogs brain health and liver health or does it just support his liver ?

Answer by ChewyJul 16, 2019
This supplement is intended to ensure stability through the digestive system and support the liver.

4.5
Rated 4.5 out of 5 stars
104 Ratings

Customers Mention

Chewy identifies key considerations with the help of artificial intelligence and our veterinarians.

Ease of Use

79% Positive

Effectiveness

88% Positive

Ingredients

84% Positive

Long-Term Benefits

88% Positive

49 Customer Reviews



Rated 5 out of 5 stars
By Amanda on Dec 16, 2025

Raise liver levels!

Our pip has seizures so his prescription medicine elevates his liver enzymes, so the vet recommended these. 6 months on it and his levels are back to normal!

Our pip has seizures so his prescription medicine elevates his liver enzymes, so the vet recommended these. 6 months on it and his levels are back to normal!


Rated 5 out of 5 stars
By Amanda on Dec 11, 2025

Helped liver levels

Our pup has seizures & his medicines raised his liver enzymes, these supplements help to keep them at a healthy level

Our pup has seizures & his medicines raised his liver enzymes, these supplements help to keep them at a healthy level


Rated 5 out of 5 stars
By Lizzy on May 31, 2025

So far so good

So far so good! We started my husky on this a month ago and I’m eager to repeat her bloodwork to see how it improves her elevations! It is a large orange pill so

So far so good! We started my husky on this a month ago and I’m eager to repeat her bloodwork to see how it improves her elevations! It is a large orange pill so I was worried she wasn’t going to eat it since she’s so picky but we put it in peanut butter and it disappears! Based on her weight this was the cheapest option for SAMe supplements and I have it on autoship!


Rated 1 out of 5 stars
By Steven on Sep 8, 2025

Too hard to give

Wish there were softgels he keeps spitting them up. Can I get a refund?

Wish there were softgels he keeps spitting them up. Can I get a refund?


Rated 2 out of 5 stars
By Catherine on Mar 9, 2025

Sad-pill shape has changed- won't work for my dog

I have purchased and given this product to my chihuahua for about 5 years. I know it has helped him and his senior years to stay alert and connected. I was so thankful

I have purchased and given this product to my chihuahua for about 5 years. I know it has helped him and his senior years to stay alert and connected. I was so thankful to discover it. SAMe is great and Vetriscience is a good brand. SAMe is also very hard to find in a pill form (needed for proper digestion) and small enough for a small dog... this product fit the bill! Until today.... I just opened my new shipment of two boxes of Vetriscience SAMe and discovered that the pill shape has changed from a nicely sized Round Disc to a classic elongated capsule shape. For a lot of dogs this might be fine. But for any dog that's a bit smaller and has a small mouth, and my dog is actually 12 lb so not tiny, this longer capsule is a problem. Getting it inside a bit of food so that my little dog will take it and be able to swallow it without struggle is now impossible. This is a game changer and I'm really sad because this product is so beneficial and this was the only version that I had found that I could give my dog. Vetriscience, please please please go back to the previous version of this product! Please bring the small circular disc pill back!


Rated 1 out of 5 stars
By Timothy on Mar 30, 2025

Still Waiting ?!

I'm still waiting for my return label "by mail" for Cubby's VETRI SAMe 2I don't have a printer. I thought this was understood and was told it would be sent via regular

I'm still waiting for my return label "by mail" for Cubby's VETRI SAMe 2I don't have a printer. I thought this was understood and was told it would be sent via regular mail. Please Help....Tim & Cubby


Rated 5 out of 5 stars
By Jennifer on Jul 3, 2025

Once daily

Our boy takes this once daily to keep his liver healthy.

Our boy takes this once daily to keep his liver healthy.


Rated 5 out of 5 stars
By Jody on May 29, 2025

how quick I received it

It's what my vet recommended and is cheaper than getting it from her.

It's what my vet recommended and is cheaper than getting it from her.


Rated 1 out of 5 stars
By Mary on Mar 25, 2025

Trying to cancel auto ship.

Not user friendly. Can’t I find where to cancel order entirely. Very difficult!

Not user friendly. Can’t I find where to cancel order entirely. Very difficult!


Rated 2 out of 5 stars
By James on Feb 10, 2025

Tablet too large for dog.

He is taking a number of meds and dosing is an issue.. A good product, but difficult to dose due to his age.

He is taking a number of meds and dosing is an issue.. A good product, but difficult to dose due to his age.