Coco and Luna SAMe S-Adenosyl-L-Methionine Soft Chew Liver Supplement for Dogs, 90 count

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At a Glance

  • Brain Health
  • Made in USA
  • All Lifestages
  • All Breeds
$24.99 First Time Autoship Price
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$44.99 Chewy Price
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About This Item

Details

  • Made in the USA in FDA-registered facilities, these soft chews are easy to feed.
  • Helps to protect the liver from damage, helps to cleanse the liver, and supports liver detox to promote overall liver health.
  • A paw-some brain supplement supports your pup’s mental activity, including cognitive and memory function, for a healthy, active life.
  • Made with medium chain triglyceride oil to maximize the supplement’s absorption and effects.
  • Free from harmful ingredients like palm oil, corn, soy derivatives, synthetic colors, and artificial flavors.

Ingredient Information

Instructions

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3.7
Rated 3.7 out of 5 stars
14 Ratings
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6 Customer Reviews

Rated 5 out of 5 stars
By Deborah on Jan 16, 2026

Heart-shaped, soft chewable; the dosage is what we needed!

Brandy has been on Sam-E for a long time. The product we ordered was discontinued, and no other brands had the 325mg strength, so we were very happy to see this

Brandy has been on Sam-E for a long time. The product we ordered was discontinued, and no other brands had the 325mg strength, so we were very happy to see this product; this is now our second purchase and is on auto ship. Brandy will be 14 on 1/21/26 and is doing fantastic!

Rated 4 out of 5 stars
By Ronda on Jul 30, 2025

This works but needs to enhance the flavor

My dog has been on Coco and Luna’s SAMe for several years and it has significantly helped her Cushing symptoms. We tried the chews since she is supposed to get this

My dog has been on Coco and Luna’s SAMe for several years and it has significantly helped her Cushing symptoms. We tried the chews since she is supposed to get this before her food and she did not like it as much as the previous option. Needs better flavor, my dog will not eat this without doctoring it up.

Rated 3 out of 5 stars
By Brian on May 12, 2025

not so tasty apparently

These are soft heart-shaped "pills" about the size of a nickel and almost as thick as they are wide. They must not taste great as Rocky shows no interest in them

These are soft heart-shaped "pills" about the size of a nickel and almost as thick as they are wide. They must not taste great as Rocky shows no interest in them on their own, but must also not be too bad either. Crumbled into his food, they get eaten.

Rated 1 out of 5 stars
By Linda on Jul 29, 2024

Dog refuses

I need to give my tiny under 5 pound dog liver protection supplements due to his liver toxic medications for seizures. I thought this chew would be better than a

I need to give my tiny under 5 pound dog liver protection supplements due to his liver toxic medications for seizures. I thought this chew would be better than a tablet. But no, my dog refuses it. He licks it. He carries it to his dog bed. He protects it from his dog sister eating it. But he won't eat it. After 20 minutes, I finally threw out the slimy chew. I spoke with the company - who said it's OK to hide in meals despite recommendation to take on empty stomach. But I can't as these need to be 2 hours away from the seizure medication which is given at his mealtimes. I just ordered from Chewy again and this time got the tablet that I can give in a pill pocket or wrapped in deli meat or cheese.

Rated 1 out of 5 stars
By Ilean on Aug 24, 2024

Just Awful !!!

I gave this to my dog for 3 days and battled runny Diarrhea for the next 7 days. My vet says anything with pea flour, pea protein or pea starch is horrible for dogs

I gave this to my dog for 3 days and battled runny Diarrhea for the next 7 days. My vet says anything with pea flour, pea protein or pea starch is horrible for dogs. I have to agree. Now I'm stuck with something useless that cost way to much.

Rated 5 out of 5 stars
By Jean on Aug 3, 2024

My dog loves to eat these.

I can't say if it has done any good for her liver yet because I've just started her on this. I'm starting with one and working up to four.

I can't say if it has done any good for her liver yet because I've just started her on this. I'm starting with one and working up to four.