Comfortis Chewable Tablet for Dogs, 10.1-20 lbs, & Cats, 6.1-12 lbs, (Orange Box), 6 Chewable Tablets (6-mos. supply)
Prescription Item
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Comfortis is a chewable medication prescribed by veterinarians for dogs and cats to help treat — and possibly even prevent — flea infestations for up to one month. These flavored tablets can be added to your pet's favorite food and only need to be given to your canine companion once a month to help combat fleas.
UsesComfortis kills fleas and is indicated for the prevention and treatment of flea infestations, for one month, on cats and kittens 14 weeks of age and older and 4.1 pounds of body weight or greater.
Possible Side EffectsThe most common side effect reported in dogs is vomiting.
Drug & Food InteractionsThere are no known drug interactions while using Comfortis.
Precautions
Comfortis chewable tablets are for use in dogs and puppies 14 weeks of age and older. Use with caution in breeding females. Use with caution in dogs with pre-existing epilepsy. The safe use of Comfortis chewable tablets in breeding males has not been evaluated.
Dosage Chart
Color on Box | Weight Range | Strength | Dosage | Product Page |
---|---|---|---|---|
Pink | Dogs 5-10 lbs / Cats 4.1-6 lbs | 140 mg Spinosad | Give orally once a month | ✓-Click Here |
Orange | Dogs 10.1-20 lbs / Cats 6.1-12 lbs | 270 mg Spinosad | Give orally once a month | ✓-Click Here |
Green | Dogs 20.1-40 lbs / Cats 12.1-24 lbs | 560 mg Spinosad | Give orally once a month | ✓-Click Here |
Blue | Dogs 40.1-60 lbs | 810 mg Spinosad | Give orally once a month | ✓-Click Here |
Brown | Dogs 60.1-120 lbs | 1620 mg Spinosad | Give orally once a month | ✓-Click Here |
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Item Number146119
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Generic NameSpinosad
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Common Brand Name(s)Comfortis, Trifexis
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For Use WithDogs & Cats
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Administration FormOral
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UsagePrevention, Treatment
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BrandElanco
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LifestageAdult, Puppy, Senior, Kitten
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Breed SizeSmall Breeds
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Product FormChewable Tablet
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Strength270 mg Spinosad
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Health ConditionFleas
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Drug TypeParasiticide
270 mg Spinosad
Dose varies based on pet's weight. Use according to your veterinarian's instructions. Comfortis is generally given once a month, but you should always follow your veterinarian's directions. It is recommended to give Comfortis chewable tablets with food.
Storage InstructionsStore at temperatures between 68° - 77°F.
What are Comfortis Tablets?
They’re beef-flavored, chewable tablets you give to your dog or cat to kill fleas and prevent flea infestations for one month. Comfortis chewable tablets are recommended for monthly use in cats 14 weeks of age or older and 4.1 lbs of body weight or greater and in dogs 14 weeks of age or older and 5 lbs of body weight or greater.
What is Spinosad?
Spinosad is the active ingredient in Comfortis. It belongs to a class of antiparasitics known as spinosyns, which are derived from a naturally-occurring soil microbe. It works by attacking the nervous system of insects, causing the rapid death of adult fleas.
When should treatment with Comfortis begin?
Treatment can begin at any time of the year. Comfortis is most effective when given one month before fleas become active, with continued monthly dosing through the end of the flea season. In areas where fleas are common year-round, monthly treatment with Comfortis chewable tablets should continue through the entire year without interruption. To minimize the likelihood of flea re-infestation, simultaneously treat all animals in your household with an approved flea protection product. Consult your veterinarian for the flea treatment options most appropriate for your area. See also, what should I discuss with my veterinarian regarding Comfortis for my dog or cat?
How quickly will Comfortis (Spinosad) kill fleas?
Spinosad, the active ingredient in Comfortis, began killing fleas in 30 minutes and killed 100% of fleas on dogs and 98% of fleas on cats in just four hours in controlled laboratory studies. Comfortis chewable tablets kill fleas before they can lay eggs.
How long does Comfortis last?
Comfortis has demonstrated full effectiveness for an entire month.
Does seeing fleas on my dog or cat means the treatment isn't working?
Comfortis kills fleas before they can lay eggs when used monthly, according to the label directions. If you see fleas on your dog or cat within a month after your pet receives Comfortis, they are most likely new fleas. Because your pet has been treated with Comfortis, these new fleas will be killed before they can produce eggs that contaminate your home. Continued monthly use of Comfortis can prevent any new flea infestations.
Your pet can experience continued exposure to fleas living in the environment. It’s important to treat all animals in the household with an approved flea product to help control the flea population. Learn more about controlling flea infestations in your home.
Is it safe to give Comfortis (Spinosad) to my dog or cat?
Comfortis has demonstrated to be safe in healthy dogs and cats when used according to label directions. Use only for cats and kittens 14 weeks of age or older and 4.1 lbs of body weight or greater, and for dogs and puppies 14 weeks of age and older and 5.0 lbs of body weight or greater. The safe use of Comfortis in breeding, pregnant or lactating cats and dogs has not been evaluated.
My pet has allergies, can he still take Comfortis?
Comfortis contains beef flavoring made from a pork-based protein. If your pet has an allergy to pork, you may need to consider an alternative for flea treatment and prevention. Please discuss these options with your pet's veterinarian. The use of ivermectin at higher than FDA-approved doses at the same time as Comfortis can result in serious side effects.
What side effects might occur with Comfortis?
As with any medication, sometimes side effects occur. See the Comfortis label for complete safety information.
For cats: In some cases, cats vomited after receiving Comfortis. If vomiting occurs within one hour of administration, re-dose with another full dose. Additional adverse reactions observed in studies were lethargy, decreased appetite, weight loss, and diarrhea. Use with caution with concomitant extra-label use of ivermectin. See the Comfortis label for complete safety information.
For dogs: The most common adverse reaction reported is vomiting. Other adverse reactions reported in decreasing order of frequency are depression/lethargy, decreased appetite, incoordination, diarrhea, itching, trembling, excessive salivation and seizures. Following concomitant extra-label use of ivermectin with Comfortis, some dogs have experienced the following clinical signs: trembling/twitching, salivation/drooling, seizures, ataxia, mydriasis, blindness, and disorientation. See the Comfortis label for complete safety information.
How should I give Comfortis (Spinosad) to my pet?
Administer Comfortis with food for maximum effectiveness. Because Comfortis is a flavored tablet, it can be offered just prior to or just after feeding. You can also administer Comfortis as you would other tablet medications. Visit the Dosing & Administration page for more details, or download the Comfortis label. Each box includes reminder stickers for your calendar to help remind you to administer each dose. You can also sign up for monthly text or email reminders.
How much food do I have to give my pet when adminisering the Comfortis Tablet?
In field trials, dog and cat owners were instructed to give the Comfortis tablet with food. However, the quantity of food was not specified and Comfortis was still effective. An option is to give Comfortis immediately before a regularly scheduled meal. For free feeders (dogs or cats who nibble throughout the day), you might take food away at night, administer Comfortis first thing in the morning, then put the food back down.
What id I miss a dose of Comfortis?
Give your pet his or her regular dose immediately, then resume a regular monthly schedule. To help you remember to dose your pet, sign up for monthly email or text message reminders. For complete safety information, view the Comfortis label.
What if I give more than the prescribed amount of Comfortis to my pet?
Contact your veterinarian if you believe your pet has ingested more than the recommended dose of Comfortis. Visit the Dosing & Administration page for more details, or see the Comfortis label for complete safety information.
Should I restrict my pet's activity or contact with my pet after the tablet is consumed?
No. You can continue normal activities and interactions with your pet.
Can other medications be given while my pet is taking Comfortis?
Comfortis is not contraindicated for use with any veterinary drug/product when they are administered at labeled doses. However, while labeled heartworm preventatives are not an issue, you should not use Comfortis concurrently with extra-label doses of ivermectin in dogs and should use caution in cats. Make sure your veterinarian is aware of all products that you intend to administer to your pet. In well-controlled field studies, Comfortis chewable tablets were administered safely in conjunction with other frequently used labeled products, such as vaccines, anthelmintics, antiparasitics, antibiotics, steroids, tick control products, anesthetics, NSAIDs, antihistamines, alternative/herbal remedies, shampoos, prescription diets, and most generally prescribed medications.
What should I discuss with my veterinarian regarding Comfortis for my dog or cat?
Your veterinarian is your pet's healthcare expert and can make the best medication recommendations. This includes the prevention, control and/or treatment of parasites such as fleas, heartworms and intestinal parasites. These parasites can cause conditions including flea allergy dermatitis, anemia, and heart disease. Key points of your discussion might include:
- The best time to start flea treatment in your geographic region.
- What administration method will work best for your pet.
- What to do if you miss a dose of Comfortis.
- What other medications you give your pet.
- What to do about a severe flea infestation.
- What steps you can take to prevent a flea re-infestation in your home.
Customer Reviews
86% Recommend
86% of reviewersrecommend this product
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100 Reviews
Showing 1-10 of 100 Reviews
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Feeding Comfortis
By Marise on Feb 5, 2021
My little dog won't eat the tablet, so I give it in his dinner; adding a little starch to the meal seems to help him digest the med with no reactions. I prepare his food, so just on Comfortis night I add a single ravioli, which he loves. Because the tablets are so expensive, I decided years ago to try cutting a tablet into quarters (since my dog only weighs 3/4th the top weight on the package), brown three tiny ground turkey balls, and put a quarter tablet inside each one after the cooking. He's been on 3/4 tab Comfortis for more than 10 years, and it works.
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Worked right away!
By Dani on Jan 21, 2021
I didn’t believe how quickly this would work but I found dying fleas within an hour after giving this to my cat. I was able to easily break the pill up into small pieces and hid it into his wet food so he ate it with no issues. I didn’t notice any serious negative side effects (drowsiness, vomiting, etc) just a slight loss of appetite the next day. The prescription process was easy. It took them a couple of days to contact my vet (I ordered on a weekend) and then once they gave the ok, it was shipped out next day.
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Piece of Mind
By JBell on Feb 15, 2021
My vet recommended this product. It’s easy to drop in with her food and she seems to eat it up without noticing. It’s nice to have piece of mind that if we do take her to the park or on a hike that she’s protected. Shout out to Chewy for such a quick turnaround time!
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CUT PILL IN HALF!!! works like a charm
By bella101 on Dec 19, 2020
So before I bought this product for my cat Bella who is 9. She had irritated skin reaction to the topical flea meds my vet had her on. He suggested an oral treatment so I thought I’d give this a try. After reading reviews about their cat puking the pill up and then reading a review about cutting it in half. Well cutting it in half works. I cut it in half put it in with her favorite wet treat and she lapped it on up and kept it down. I gave her the second half in the other half of the wet treat 2.5 hrs later and she kept it down. She’s stopped constantly scratching and has calmed down. Flea problem solved. I will be purchasing again
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works if you can get it in them
By Upsetowner on Dec 19, 2020
I highly recommend caution with this product. It works if you can get it in them. Be aware that this pill is larger than I expected. Zero chance for me to force it down my cats.ast time I gave a pill the way the vet said I spent a week in the hospital with cat scratch fever (a real.thing). The only other thing I could do was crush it and mix it in their food. But my cats can either smell it or taste it and want nothing to do with their food even though I have put their dry food up last night. All I'm saying is it's absolutely worthless if you can't get your cats to eat it
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Finally relief for my kitty!
By BeachBummer on Dec 2, 2020
Our indoor cat is generally super tolerant and chill, but ended up with some stubborn fleas that where driving him to ceaselessly over grooming. After trying a variety of topical products, baths, home sprays & even carpet removal my cat was still plagued with flea related skin allergies. I had been slow about deciding to take him to the vet (given the pandemic), but with no other viable solution I took him to get a prescription and this is the product of vet recommends as an oral flea treatment for cats...but they didn’t have any in stock! I went home and logged into Chewy and was dismayed to find a mailed in prescription can take them two weeks to receive and process prior to shipping, so I Our indoor cat is generally super tolerant and chill, but ended up with some stubborn fleas that where driving him to ceaselessly over grooming. After trying a variety of topical products, baths, home sprays & even carpet removal my cat was still plagued with flea related skin allergies. I had been slow about deciding to take him to the vet (given the pandemic), but with no other viable solution I took him to get a prescription and this is the product of vet recommends as an oral flea treatment for cats...but they didn’t have any in stock! I went home and logged into Chewy and was dismayed to find a mailed in prescription can take them two weeks to receive and process prior to shipping, so I sent an email asking about their confirmation process & received an almost instantaneous reply (less than an hour, late on a Friday night) and they where able to call our vet on Saturday to confirm the prescription and begin processing the order. The tablets are a little large (and bitter smelling), whatever flavor they are supposed to be isn’t sufficient to make them appetizing to a cat, he seemed to tolerate the pill well (I did not crush it...I’ve never been able to get the cat to eat “tampered” food, so I have to go the route of putting the whole pill as far back on his tongue as possible). I had noticed other reviewers saying it made their cat vomit, but mine had no problem keeping it down (he isn’t prone to throwing up though, some cats seem to be “hair trigger” when it comes to that) So far, this has been the most effective treatment we’ve tried this year and I haven’t found an active (live) flea on the cat after just the first dose. TL;DR Cat was miserable with fleas, nothing over the counter worked, vet was out of pills, Chewy processed & shipped the new prescription in a few days, it seems to have solved my cats flea problem when nothing else I tried worked sufficiently. … more
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happy kitty
By FARMMom on Jan 16, 2021
On one of my cats, I have been battling fleas, using Advantage and natural products, on just her, nothing was relieving her of the fleas. My vet ordered this and it works!! I do not like using products on my animals but when there's a must, this worked.
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Cats cannot keep pill down
By GeorgeAndPappy on Oct 27, 2020
My cats CANNOT keep these down and judging by other reviews, this is a common issue (why???). I have tried giving it with food as recommended and also an hour after dinner. On one occasion they threw it up about 90 minutes later and the manufacturer says it should be effective as long as they keep it in their system for an hour so I did not use secondary method. It seems to have kept fleas at bay during the allotted 30 day period. The remaining 3 doses were all vomited back up within 20 minutes. I will never order this product again. The drops are a pain because they scratch and lick the treated area, and it smells bad, but what other option is there... Also, these pills are HUGE. My cats CANNOT keep these down and judging by other reviews, this is a common issue (why???). I have tried giving it with food as recommended and also an hour after dinner. On one occasion they threw it up about 90 minutes later and the manufacturer says it should be effective as long as they keep it in their system for an hour so I did not use secondary method. It seems to have kept fleas at bay during the allotted 30 day period. The remaining 3 doses were all vomited back up within 20 minutes. I will never order this product again. The drops are a pain because they scratch and lick the treated area, and it smells bad, but what other option is there... Also, these pills are HUGE. they must be cut in half for me to be able to shove it down their throats. It's quite traumatic for everyone involved even with a "piller". … more
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Last resort when nothing else was working
By HappyFurBabies on Oct 26, 2020
My cat's got a horrible infestation this year, and nothing was working I tried Bayer, Frontline, Non-chemical sprays & wipes, collars & bathing them. No matter what I did nothing was breaking the life cycle. The only thing that would give my babies relief was Capstar but sadly it only lasts for a day, and after searching I found Comfortis and took my oldest to the vet and hoped it would help. After reading reviews about cats getting sick because of how strong the pill is, I wasn't going to take any chances and I gave my cats half of the pill and gave them the other half 4 hours later. So far it seems to be working I am seeing dead fleas on my cats and on the cat beds, and my babies are finally My cat's got a horrible infestation this year, and nothing was working I tried Bayer, Frontline, Non-chemical sprays & wipes, collars & bathing them. No matter what I did nothing was breaking the life cycle. The only thing that would give my babies relief was Capstar but sadly it only lasts for a day, and after searching I found Comfortis and took my oldest to the vet and hoped it would help. After reading reviews about cats getting sick because of how strong the pill is, I wasn't going to take any chances and I gave my cats half of the pill and gave them the other half 4 hours later. So far it seems to be working I am seeing dead fleas on my cats and on the cat beds, and my babies are finally getting much-needed sleep without having to scratch themselves raw. … more
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Works but only when it stays down
By Meeshlog on Oct 19, 2020
This works well but, the last three times I gave it to our cat she threw up her dinner. I tried breaking it up into two meals but that doesn’t always help. I’m not sure what to do because I don’t want to keep wasting my money on this Rx if it’s not going to make it into her system to protect her. She’s 11 pounds and we give her the tablet that says “for cats up to 12 pounds, so I’m not sure why she’s not able to keep it down. Disappointed.